FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170858747> ?p ?o ?g. }

• W2170858747 endingPage "82" @default.
• W2170858747 startingPage "74" @default.
• W2170858747 abstract "Nose-only exposure is used to study the distribution and toxicity of airborne contaminants. Restraint of animals in nose-only tubes causes stress, but the impact on pulmonary mRNA levels is unknown. Since stress and xenobiotics activate common pathways, we assessed whether nose-only exposure would alter expression of toxicologically relevant genes in the lungs. To identify candidate genes for further analysis, we first interrogated microarray data to examine time-dependent changes in gene expression in air-control animals from a nose-only inhalation study involving male wild-type C57BL/6 mice and transgenic tumor necrosis factor (TNF)-alpha over-expressing littermates. Comparison of transcript levels immediately and 24 h after a single 4-h nose-only exposure to air revealed differential expression of 280 genes (false discovery rate-adjusted, p < .05). Functional analysis revealed enrichment of immune response, apoptosis, and signalling terms, consistent with effects of restraint stress. We then selected a subset of target genes for comparison of naive animals and air-exposed animals from the inhalation study by real-time polymerase chain reaction (PCR). Expression of genes involved in stress (BNIP, sestrin-1, CDKN1A [p21], GADD45 gamma), glucocorticoid-response (GILZ, Sgk), and signal transduction (MAP3K6, C/EBP-delta) was increased as a result of nose-only exposure (p < .05). In contrast, proinflammatory factors (lymphotoxin-beta, chemokine receptor CXCR5) were decreased (p < .05). Immune gene responses observed in wild-type animals were reduced in animals with lung inflammation, indicating that pathological states can modify the response to nose-only exposure. Observed responses may warrant consideration in the evaluation of materials delivered by nose-only inhalation, and suggest that incorporation of naive animals into nose-only studies should be considered as a best practice." @default.
• W2170858747 created "2016-06-24" @default.
• W2170858747 creator A5038066341 @default.
• W2170858747 creator A5039435796 @default.
• W2170858747 creator A5044032784 @default.
• W2170858747 creator A5077375577 @default.
• W2170858747 date "2009-06-30" @default.
• W2170858747 modified "2023-09-25" @default.
• W2170858747 title "Impact of nose-only exposure system on pulmonary gene expression" @default.
• W2170858747 cites W1514230952 @default.
• W2170858747 cites W1802936766 @default.
• W2170858747 cites W1964319442 @default.
• W2170858747 cites W1987183940 @default.
• W2170858747 cites W1987912134 @default.
• W2170858747 cites W1988750935 @default.
• W2170858747 cites W1990758812 @default.
• W2170858747 cites W1999526925 @default.
• W2170858747 cites W2005698033 @default.
• W2170858747 cites W2009721053 @default.
• W2170858747 cites W2024636147 @default.
• W2170858747 cites W2048316119 @default.
• W2170858747 cites W2051473335 @default.
• W2170858747 cites W2055335169 @default.
• W2170858747 cites W2056778486 @default.
• W2170858747 cites W2057604784 @default.
• W2170858747 cites W2066985195 @default.
• W2170858747 cites W2077098267 @default.
• W2170858747 cites W2079664619 @default.
• W2170858747 cites W2080347432 @default.
• W2170858747 cites W2082835152 @default.
• W2170858747 cites W2097558756 @default.
• W2170858747 cites W2100668965 @default.
• W2170858747 cites W2107277218 @default.
• W2170858747 cites W2107447190 @default.
• W2170858747 cites W2110891968 @default.
• W2170858747 cites W2122683221 @default.
• W2170858747 cites W2135685983 @default.
• W2170858747 cites W2139219253 @default.
• W2170858747 cites W2140764802 @default.
• W2170858747 cites W2158122675 @default.
• W2170858747 cites W2160000741 @default.
• W2170858747 cites W2166215442 @default.
• W2170858747 cites W2253617528 @default.
• W2170858747 doi "https://doi.org/10.1080/08958370902962309" @default.
• W2170858747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19558237" @default.
• W2170858747 hasPublicationYear "2009" @default.
• W2170858747 type Work @default.
• W2170858747 sameAs 2170858747 @default.
• W2170858747 citedByCount "16" @default.
• W2170858747 countsByYear W21708587472012 @default.
• W2170858747 countsByYear W21708587472013 @default.
• W2170858747 countsByYear W21708587472014 @default.
• W2170858747 countsByYear W21708587472015 @default.
• W2170858747 countsByYear W21708587472016 @default.
• W2170858747 countsByYear W21708587472020 @default.
• W2170858747 countsByYear W21708587472021 @default.
• W2170858747 countsByYear W21708587472023 @default.
• W2170858747 crossrefType "journal-article" @default.
• W2170858747 hasAuthorship W2170858747A5038066341 @default.
• W2170858747 hasAuthorship W2170858747A5039435796 @default.
• W2170858747 hasAuthorship W2170858747A5044032784 @default.
• W2170858747 hasAuthorship W2170858747A5077375577 @default.
• W2170858747 hasConcept C104317684 @default.
• W2170858747 hasConcept C105702510 @default.
• W2170858747 hasConcept C13373296 @default.
• W2170858747 hasConcept C150194340 @default.
• W2170858747 hasConcept C164027704 @default.
• W2170858747 hasConcept C186836561 @default.
• W2170858747 hasConcept C203014093 @default.
• W2170858747 hasConcept C2776914184 @default.
• W2170858747 hasConcept C2778311950 @default.
• W2170858747 hasConcept C2780841215 @default.
• W2170858747 hasConcept C48023723 @default.
• W2170858747 hasConcept C54355233 @default.
• W2170858747 hasConcept C59493245 @default.
• W2170858747 hasConcept C86803240 @default.
• W2170858747 hasConceptScore W2170858747C104317684 @default.
• W2170858747 hasConceptScore W2170858747C105702510 @default.
• W2170858747 hasConceptScore W2170858747C13373296 @default.
• W2170858747 hasConceptScore W2170858747C150194340 @default.
• W2170858747 hasConceptScore W2170858747C164027704 @default.
• W2170858747 hasConceptScore W2170858747C186836561 @default.
• W2170858747 hasConceptScore W2170858747C203014093 @default.
• W2170858747 hasConceptScore W2170858747C2776914184 @default.
• W2170858747 hasConceptScore W2170858747C2778311950 @default.
• W2170858747 hasConceptScore W2170858747C2780841215 @default.
• W2170858747 hasConceptScore W2170858747C48023723 @default.
• W2170858747 hasConceptScore W2170858747C54355233 @default.
• W2170858747 hasConceptScore W2170858747C59493245 @default.
• W2170858747 hasConceptScore W2170858747C86803240 @default.
• W2170858747 hasIssue "sup1" @default.
• W2170858747 hasLocation W21708587471 @default.
• W2170858747 hasLocation W21708587472 @default.
• W2170858747 hasOpenAccess W2170858747 @default.
• W2170858747 hasPrimaryLocation W21708587471 @default.
• W2170858747 hasRelatedWork W1975495128 @default.
• W2170858747 hasRelatedWork W2026729962 @default.
• W2170858747 hasRelatedWork W2061930728 @default.

• next