FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170864437> ?p ?o ?g. }

• W2170864437 endingPage "421" @default.
• W2170864437 startingPage "415" @default.
• W2170864437 abstract "The most unique feature of ghrelin is the acyl-modification of a hydroxyl group of the Ser3 in the N-terminus. The Ser3 is commonly modified by n-octanoic acid in vertebrates being needed for its biological effects, at least in terms of feeding. Therefore, a critical question regarding the role of ghrelin was to characterize the mechanism involved in its acylation. The acyltransferase that catalyzes ghrelin octanoylation has been recently identified and named ghrelin O-acyltransferase (GOAT). The aim of this study was to clarify the physiological implications of GOAT in the regulation of energy balance, by assessing the effect of undernutrition, as well as fasting in adult male rats. We have determined GOAT mRNA expression levels by real time-PCR in the stomach mucosa. Our results show that chronic food restriction led to an increase in GOAT mRNA, particularly following long-term chronic malnutrition (21 days). Furthermore, following 48 h complete fasting, a situation with high-circulating ghrelin levels, we found similar mRNA expression of GOAT in fed and fasted rats; exogenous leptin administration markedly increase GOAT mRNA levels in the stomach mucosa of fasted rats. These findings suggest that increased GOAT mRNA levels may have a role in mediating the physiological responses to chronic undernutrition and could represent an adaptive response to prevent long-lasting alterations in energy balance and body weight homeostasis. Furthermore, our data also offer mechanistic insights into the reason why during fasting acylated ghrelin levels are not increased at a time when a marked increase in an orexigenic signal as important as acylated ghrelin will be expected." @default.
• W2170864437 created "2016-06-24" @default.
• W2170864437 creator A5028809564 @default.
• W2170864437 creator A5044168126 @default.
• W2170864437 creator A5062007059 @default.
• W2170864437 creator A5085470797 @default.
• W2170864437 date "2008-10-03" @default.
• W2170864437 modified "2023-10-03" @default.
• W2170864437 title "Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa" @default.
• W2170864437 cites W1637971961 @default.
• W2170864437 cites W1968200399 @default.
• W2170864437 cites W1971388047 @default.
• W2170864437 cites W1973102414 @default.
• W2170864437 cites W1982697751 @default.
• W2170864437 cites W1988347665 @default.
• W2170864437 cites W1989130418 @default.
• W2170864437 cites W1989237770 @default.
• W2170864437 cites W2005409308 @default.
• W2170864437 cites W2018127398 @default.
• W2170864437 cites W2020843850 @default.
• W2170864437 cites W2024967835 @default.
• W2170864437 cites W2048053645 @default.
• W2170864437 cites W2066242978 @default.
• W2170864437 cites W2066247992 @default.
• W2170864437 cites W2069302715 @default.
• W2170864437 cites W2073118840 @default.
• W2170864437 cites W2085181449 @default.
• W2170864437 cites W2090183863 @default.
• W2170864437 cites W2090389952 @default.
• W2170864437 cites W2103415712 @default.
• W2170864437 cites W2107620313 @default.
• W2170864437 cites W2109993485 @default.
• W2170864437 cites W2112085129 @default.
• W2170864437 cites W2112202133 @default.
• W2170864437 cites W2112947586 @default.
• W2170864437 cites W2113244359 @default.
• W2170864437 cites W2115575621 @default.
• W2170864437 cites W2117421165 @default.
• W2170864437 cites W2144648093 @default.
• W2170864437 cites W2153184502 @default.
• W2170864437 cites W2163865122 @default.
• W2170864437 cites W2166671643 @default.
• W2170864437 cites W2172296871 @default.
• W2170864437 cites W74158845 @default.
• W2170864437 doi "https://doi.org/10.1677/jme-08-0102" @default.
• W2170864437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18835978" @default.
• W2170864437 hasPublicationYear "2008" @default.
• W2170864437 type Work @default.
• W2170864437 sameAs 2170864437 @default.
• W2170864437 citedByCount "78" @default.
• W2170864437 countsByYear W21708644372012 @default.
• W2170864437 countsByYear W21708644372013 @default.
• W2170864437 countsByYear W21708644372014 @default.
• W2170864437 countsByYear W21708644372015 @default.
• W2170864437 countsByYear W21708644372016 @default.
• W2170864437 countsByYear W21708644372017 @default.
• W2170864437 countsByYear W21708644372018 @default.
• W2170864437 countsByYear W21708644372019 @default.
• W2170864437 countsByYear W21708644372020 @default.
• W2170864437 countsByYear W21708644372021 @default.
• W2170864437 countsByYear W21708644372023 @default.
• W2170864437 crossrefType "journal-article" @default.
• W2170864437 hasAuthorship W2170864437A5028809564 @default.
• W2170864437 hasAuthorship W2170864437A5044168126 @default.
• W2170864437 hasAuthorship W2170864437A5062007059 @default.
• W2170864437 hasAuthorship W2170864437A5085470797 @default.
• W2170864437 hasBestOaLocation W21708644371 @default.
• W2170864437 hasConcept C104317684 @default.
• W2170864437 hasConcept C105580179 @default.
• W2170864437 hasConcept C118303440 @default.
• W2170864437 hasConcept C126322002 @default.
• W2170864437 hasConcept C134018914 @default.
• W2170864437 hasConcept C170493617 @default.
• W2170864437 hasConcept C2491326 @default.
• W2170864437 hasConcept C2777205416 @default.
• W2170864437 hasConcept C2779357093 @default.
• W2170864437 hasConcept C2779422922 @default.
• W2170864437 hasConcept C2780613262 @default.
• W2170864437 hasConcept C2781443798 @default.
• W2170864437 hasConcept C511355011 @default.
• W2170864437 hasConcept C551997983 @default.
• W2170864437 hasConcept C55493867 @default.
• W2170864437 hasConcept C63645605 @default.
• W2170864437 hasConcept C71315377 @default.
• W2170864437 hasConcept C71924100 @default.
• W2170864437 hasConcept C86803240 @default.
• W2170864437 hasConcept C93984277 @default.
• W2170864437 hasConceptScore W2170864437C104317684 @default.
• W2170864437 hasConceptScore W2170864437C105580179 @default.
• W2170864437 hasConceptScore W2170864437C118303440 @default.
• W2170864437 hasConceptScore W2170864437C126322002 @default.
• W2170864437 hasConceptScore W2170864437C134018914 @default.
• W2170864437 hasConceptScore W2170864437C170493617 @default.
• W2170864437 hasConceptScore W2170864437C2491326 @default.
• W2170864437 hasConceptScore W2170864437C2777205416 @default.
• W2170864437 hasConceptScore W2170864437C2779357093 @default.
• W2170864437 hasConceptScore W2170864437C2779422922 @default.
• W2170864437 hasConceptScore W2170864437C2780613262 @default.

• next