FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170864497> ?p ?o ?g. }

• W2170864497 endingPage "372" @default.
• W2170864497 startingPage "365" @default.
• W2170864497 abstract "This study aimed to evaluate the association between the differential gene expression profiling of peripheral blood mononuclear cells of rheumatoid arthritis patients with their immunogenetic (human leucocyte antigen shared-epitope, HLA-SE), autoimmune response [anti-cyclic citrullinated peptide (CCP) antibodies], disease activity score (DAS-28) and treatment (disease-modifying antirheumatic drugs and tumour necrosis factor blocker) features. Total RNA samples were copied into Cy3-labelled complementary DNA probes, hybridized onto a glass slide microarray containing 4500 human IMAGE complementary DNA target sequences. The Cy3-monocolour microarray images from patients were quantified and normalized. Analysis of the data using the significance analysis of microarrays algorithm together with a Venn diagram allowed the identification of shared and of exclusively modulated genes, according to patient features. Thirteen genes were exclusively associated with the presence of HLA-SE alleles, whose major biological function was related to signal transduction, phosphorylation and apoptosis. Ninety-one genes were associated with disease activity, being involved in signal transduction, apoptosis, response to stress and DNA damage. One hundred and one genes were associated with the presence of anti-CCP antibodies, being involved in signal transduction, cell proliferation and apoptosis. Twenty-eight genes were associated with tumour necrosis factor blocker treatment, being involved in intracellular signalling cascade, phosphorylation and protein transport. Some of these genes had been previously associated with rheumatoid arthritis pathogenesis, whereas others were unveiled for future research." @default.
• W2170864497 created "2016-06-24" @default.
• W2170864497 creator A5000757063 @default.
• W2170864497 creator A5002854120 @default.
• W2170864497 creator A5005316342 @default.
• W2170864497 creator A5028687670 @default.
• W2170864497 creator A5050708797 @default.
• W2170864497 creator A5056438560 @default.
• W2170864497 creator A5061587246 @default.
• W2170864497 creator A5071532772 @default.
• W2170864497 creator A5074529193 @default.
• W2170864497 creator A5078765495 @default.
• W2170864497 creator A5091102184 @default.
• W2170864497 date "2009-07-01" @default.
• W2170864497 modified "2023-09-26" @default.
• W2170864497 title "Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features" @default.
• W2170864497 cites W1519045334 @default.
• W2170864497 cites W1582344203 @default.
• W2170864497 cites W1964890547 @default.
• W2170864497 cites W1966032563 @default.
• W2170864497 cites W1981501686 @default.
• W2170864497 cites W2001620383 @default.
• W2170864497 cites W2015865604 @default.
• W2170864497 cites W2024988150 @default.
• W2170864497 cites W2031685248 @default.
• W2170864497 cites W2049662852 @default.
• W2170864497 cites W2062330878 @default.
• W2170864497 cites W2063010247 @default.
• W2170864497 cites W2065111421 @default.
• W2170864497 cites W2072988410 @default.
• W2170864497 cites W2093120748 @default.
• W2170864497 cites W2094282176 @default.
• W2170864497 cites W2095087692 @default.
• W2170864497 cites W2099388441 @default.
• W2170864497 cites W2099659190 @default.
• W2170864497 cites W2105066639 @default.
• W2170864497 cites W2110177517 @default.
• W2170864497 cites W2122014680 @default.
• W2170864497 cites W2122523262 @default.
• W2170864497 cites W2130631271 @default.
• W2170864497 cites W2134441843 @default.
• W2170864497 cites W2137234819 @default.
• W2170864497 cites W2145160598 @default.
• W2170864497 cites W2152348310 @default.
• W2170864497 cites W2344127362 @default.
• W2170864497 cites W4294107304 @default.
• W2170864497 cites W45534775 @default.
• W2170864497 doi "https://doi.org/10.1111/j.1365-2567.2008.03005.x" @default.
• W2170864497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2712105" @default.
• W2170864497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19191904" @default.
• W2170864497 hasPublicationYear "2009" @default.
• W2170864497 type Work @default.
• W2170864497 sameAs 2170864497 @default.
• W2170864497 citedByCount "21" @default.
• W2170864497 countsByYear W21708644972012 @default.
• W2170864497 countsByYear W21708644972013 @default.
• W2170864497 countsByYear W21708644972014 @default.
• W2170864497 countsByYear W21708644972015 @default.
• W2170864497 countsByYear W21708644972017 @default.
• W2170864497 countsByYear W21708644972021 @default.
• W2170864497 crossrefType "journal-article" @default.
• W2170864497 hasAuthorship W2170864497A5000757063 @default.
• W2170864497 hasAuthorship W2170864497A5002854120 @default.
• W2170864497 hasAuthorship W2170864497A5005316342 @default.
• W2170864497 hasAuthorship W2170864497A5028687670 @default.
• W2170864497 hasAuthorship W2170864497A5050708797 @default.
• W2170864497 hasAuthorship W2170864497A5056438560 @default.
• W2170864497 hasAuthorship W2170864497A5061587246 @default.
• W2170864497 hasAuthorship W2170864497A5071532772 @default.
• W2170864497 hasAuthorship W2170864497A5074529193 @default.
• W2170864497 hasAuthorship W2170864497A5078765495 @default.
• W2170864497 hasAuthorship W2170864497A5091102184 @default.
• W2170864497 hasBestOaLocation W21708644972 @default.
• W2170864497 hasConcept C104317684 @default.
• W2170864497 hasConcept C137061746 @default.
• W2170864497 hasConcept C147483822 @default.
• W2170864497 hasConcept C150194340 @default.
• W2170864497 hasConcept C18431079 @default.
• W2170864497 hasConcept C186836561 @default.
• W2170864497 hasConcept C188280979 @default.
• W2170864497 hasConcept C202751555 @default.
• W2170864497 hasConcept C203014093 @default.
• W2170864497 hasConcept C2776232647 @default.
• W2170864497 hasConcept C2777575956 @default.
• W2170864497 hasConcept C502942594 @default.
• W2170864497 hasConcept C54355233 @default.
• W2170864497 hasConcept C62478195 @default.
• W2170864497 hasConcept C86803240 @default.
• W2170864497 hasConceptScore W2170864497C104317684 @default.
• W2170864497 hasConceptScore W2170864497C137061746 @default.
• W2170864497 hasConceptScore W2170864497C147483822 @default.
• W2170864497 hasConceptScore W2170864497C150194340 @default.
• W2170864497 hasConceptScore W2170864497C18431079 @default.
• W2170864497 hasConceptScore W2170864497C186836561 @default.
• W2170864497 hasConceptScore W2170864497C188280979 @default.
• W2170864497 hasConceptScore W2170864497C202751555 @default.
• W2170864497 hasConceptScore W2170864497C203014093 @default.
• W2170864497 hasConceptScore W2170864497C2776232647 @default.

• next