FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170865129> ?p ?o ?g. }

• W2170865129 endingPage "5425" @default.
• W2170865129 startingPage "5415" @default.
• W2170865129 abstract "The cell adhesion molecule N-cadherin is ubiquitously expressed in the early neuroepithelium, with strongest expression in the ependymal lining. We blocked the function of N-cadherin during early chicken brain development by injecting antibodies against N-cadherin into the tectal ventricle of embryos at 4–5 d of incubation [embryonic day 4 (E4)–E5]. N-cadherin blockage results in massive morphological changes in restricted brain regions. At approximately E6, these changes consist of invaginations of pieces of the ependymal lining and the formation of neuroepithelial rosettes. The rosettes are composed of central fragments of ependymal lining, surrounded by an inner ventricular layer and an outer mantle layer. Radial glia processes are radially arranged around the ependymal centers of the rosettes. The normal layering of the neural tissue is thus preserved, but its coherent epithelial structure is disrupted. The observed morphological changes are restricted to specific brain regions such as the tectum and the dorsal thalamus, whereas the ventral thalamus and the pretectum are almost undisturbed. At E10–E11, analysis of late effects of N-cadherin blockage reveals that in the dorsal thalamus, gray matter is fragmented and disorganized; in the tectum, additional layers have formed at the ventricular surface. Together, these results indicate that N-cadherin function is required for the maintenance of a coherent sheet of neuroepithelium in specific brain regions. Disruption of this sheet results in an abnormal morphogenesis of brain gray matter." @default.
• W2170865129 created "2016-06-24" @default.
• W2170865129 creator A5044566638 @default.
• W2170865129 creator A5052796016 @default.
• W2170865129 date "1998-07-15" @default.
• W2170865129 modified "2023-10-16" @default.
• W2170865129 title "Blocking N-Cadherin Function Disrupts the Epithelial Structure of Differentiating Neural Tissue in the Embryonic Chicken Brain" @default.
• W2170865129 cites W1762551333 @default.
• W2170865129 cites W1817075347 @default.
• W2170865129 cites W1835871649 @default.
• W2170865129 cites W1892224664 @default.
• W2170865129 cites W1892956461 @default.
• W2170865129 cites W1906832763 @default.
• W2170865129 cites W1965063265 @default.
• W2170865129 cites W1966287842 @default.
• W2170865129 cites W1967421456 @default.
• W2170865129 cites W1967751087 @default.
• W2170865129 cites W1969742740 @default.
• W2170865129 cites W1970680825 @default.
• W2170865129 cites W1972061989 @default.
• W2170865129 cites W1973131553 @default.
• W2170865129 cites W1974199680 @default.
• W2170865129 cites W198520409 @default.
• W2170865129 cites W1986733854 @default.
• W2170865129 cites W1992267627 @default.
• W2170865129 cites W1997481445 @default.
• W2170865129 cites W1998235437 @default.
• W2170865129 cites W1999758837 @default.
• W2170865129 cites W2006754137 @default.
• W2170865129 cites W2006913118 @default.
• W2170865129 cites W2014529744 @default.
• W2170865129 cites W2014573698 @default.
• W2170865129 cites W2019416669 @default.
• W2170865129 cites W2023618495 @default.
• W2170865129 cites W2024669433 @default.
• W2170865129 cites W2024718331 @default.
• W2170865129 cites W2025478779 @default.
• W2170865129 cites W2027937187 @default.
• W2170865129 cites W2033401875 @default.
• W2170865129 cites W2039378730 @default.
• W2170865129 cites W2039493143 @default.
• W2170865129 cites W2044084549 @default.
• W2170865129 cites W2044952481 @default.
• W2170865129 cites W2048386576 @default.
• W2170865129 cites W2050195656 @default.
• W2170865129 cites W2053115961 @default.
• W2170865129 cites W2054056891 @default.
• W2170865129 cites W2057974199 @default.
• W2170865129 cites W2058785291 @default.
• W2170865129 cites W2059151146 @default.
• W2170865129 cites W2060708053 @default.
• W2170865129 cites W2069865992 @default.
• W2170865129 cites W2078624314 @default.
• W2170865129 cites W2082777494 @default.
• W2170865129 cites W2085690052 @default.
• W2170865129 cites W2091726041 @default.
• W2170865129 cites W2104789206 @default.
• W2170865129 cites W2116355277 @default.
• W2170865129 cites W2132014704 @default.
• W2170865129 cites W2136648925 @default.
• W2170865129 cites W2140034535 @default.
• W2170865129 cites W2146934540 @default.
• W2170865129 cites W2149202604 @default.
• W2170865129 cites W2151876618 @default.
• W2170865129 cites W2154228322 @default.
• W2170865129 cites W2172172421 @default.
• W2170865129 cites W4253556663 @default.
• W2170865129 doi "https://doi.org/10.1523/jneurosci.18-14-05415.1998" @default.
• W2170865129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793493" @default.
• W2170865129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9651223" @default.
• W2170865129 hasPublicationYear "1998" @default.
• W2170865129 type Work @default.
• W2170865129 sameAs 2170865129 @default.
• W2170865129 citedByCount "84" @default.
• W2170865129 countsByYear W21708651292012 @default.
• W2170865129 countsByYear W21708651292013 @default.
• W2170865129 countsByYear W21708651292014 @default.
• W2170865129 countsByYear W21708651292015 @default.
• W2170865129 countsByYear W21708651292016 @default.
• W2170865129 countsByYear W21708651292017 @default.
• W2170865129 countsByYear W21708651292018 @default.
• W2170865129 countsByYear W21708651292019 @default.
• W2170865129 countsByYear W21708651292020 @default.
• W2170865129 countsByYear W21708651292021 @default.
• W2170865129 countsByYear W21708651292022 @default.
• W2170865129 countsByYear W21708651292023 @default.
• W2170865129 crossrefType "journal-article" @default.
• W2170865129 hasAuthorship W2170865129A5044566638 @default.
• W2170865129 hasAuthorship W2170865129A5052796016 @default.
• W2170865129 hasBestOaLocation W21708651291 @default.
• W2170865129 hasConcept C104317684 @default.
• W2170865129 hasConcept C105702510 @default.
• W2170865129 hasConcept C136834591 @default.
• W2170865129 hasConcept C145103041 @default.
• W2170865129 hasConcept C1491633281 @default.
• W2170865129 hasConcept C149402561 @default.
• W2170865129 hasConcept C169760540 @default.
• W2170865129 hasConcept C200707615 @default.

• next