FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170874906> ?p ?o ?g. }

• W2170874906 endingPage "3692" @default.
• W2170874906 startingPage "3688" @default.
• W2170874906 abstract "ABSTRACT Two putative malate dehydrogenase genes, MJ1425 and MJ0490, from Methanococcus jannaschii and one from Methanothermus fervidus were cloned and overexpressed in Escherichia coli , and their gene products were tested for the ability to catalyze pyridine nucleotide-dependent oxidation and reduction reactions of the following α-hydroxy–α-keto acid pairs: ( S )-sulfolactic acid and sulfopyruvic acid; ( S )-α-hydroxyglutaric acid and α-ketoglutaric acid; ( S )-lactic acid and pyruvic acid; and 1-hydroxy-1,3,4,6-hexanetetracarboxylic acid and 1-oxo-1,3,4,6-hexanetetracarboxylic acid. Each of these reactions is involved in the formation of coenzyme M, methanopterin, coenzyme F 420 , and methanofuran, respectively. Both the MJ1425-encoded enzyme and the MJ0490-encoded enzyme were found to function to different degrees as malate dehydrogenases, reducing oxalacetate to ( S )-malate using either NADH or NADPH as a reductant. Both enzymes were found to use either NADH or NADPH to reduce sulfopyruvate to ( S )-sulfolactate, but the V max / K m value for the reduction of sulfopyruvate by NADH using the MJ1425-encoded enzyme was 20 times greater than any other combination of enzymes and pyridine nucleotides. Both the M. fervidus and the MJ1425-encoded enzyme catalyzed the NAD + -dependent oxidation of ( S )-sulfolactate to sulfopyruvate. The MJ1425-encoded enzyme also catalyzed the NADH-dependent reduction of α-ketoglutaric acid to ( S )-hydroxyglutaric acid, a component of methanopterin. Neither of the enzymes reduced pyruvate to ( S )-lactate, a component of coenzyme F 420 . Only the MJ1425-encoded enzyme was found to reduce 1-oxo-1,3,4,6-hexanetetracarboxylic acid, and this reduction occurred only to a small extent and produced an isomer of 1-hydroxy-1,3,4,6-hexanetetracarboxylic acid that is not involved in the biosynthesis of methanofuran c. We conclude that the MJ1425-encoded enzyme is likely to be involved in the biosynthesis of both coenzyme M and methanopterin." @default.
• W2170874906 created "2016-06-24" @default.
• W2170874906 creator A5026148404 @default.
• W2170874906 creator A5066432564 @default.
• W2170874906 creator A5069369769 @default.
• W2170874906 date "2000-07-01" @default.
• W2170874906 modified "2023-10-16" @default.
• W2170874906 title "Identification of an Archaeal 2-Hydroxy Acid Dehydrogenase Catalyzing Reactions Involved in Coenzyme Biosynthesis in Methanoarchaea" @default.
• W2170874906 cites W102678900 @default.
• W2170874906 cites W1524488521 @default.
• W2170874906 cites W1546319845 @default.
• W2170874906 cites W1565187280 @default.
• W2170874906 cites W1896595404 @default.
• W2170874906 cites W1947962930 @default.
• W2170874906 cites W1972495779 @default.
• W2170874906 cites W1972839105 @default.
• W2170874906 cites W1978600624 @default.
• W2170874906 cites W1979171257 @default.
• W2170874906 cites W1981124307 @default.
• W2170874906 cites W1986225499 @default.
• W2170874906 cites W1993638379 @default.
• W2170874906 cites W2007725690 @default.
• W2170874906 cites W2012684482 @default.
• W2170874906 cites W2014341740 @default.
• W2170874906 cites W2014567246 @default.
• W2170874906 cites W2017931965 @default.
• W2170874906 cites W2029242813 @default.
• W2170874906 cites W2030765768 @default.
• W2170874906 cites W2031755031 @default.
• W2170874906 cites W2032840413 @default.
• W2170874906 cites W2053653645 @default.
• W2170874906 cites W2060282846 @default.
• W2170874906 cites W2073466338 @default.
• W2170874906 cites W2074170251 @default.
• W2170874906 cites W2082853944 @default.
• W2170874906 cites W2145465660 @default.
• W2170874906 cites W2154314518 @default.
• W2170874906 cites W2302844416 @default.
• W2170874906 cites W3028251373 @default.
• W2170874906 cites W4239833500 @default.
• W2170874906 cites W4254113972 @default.
• W2170874906 cites W889419737 @default.
• W2170874906 doi "https://doi.org/10.1128/jb.182.13.3688-3692.2000" @default.
• W2170874906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/94539" @default.
• W2170874906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10850983" @default.
• W2170874906 hasPublicationYear "2000" @default.
• W2170874906 type Work @default.
• W2170874906 sameAs 2170874906 @default.
• W2170874906 citedByCount "61" @default.
• W2170874906 countsByYear W21708749062013 @default.
• W2170874906 countsByYear W21708749062014 @default.
• W2170874906 countsByYear W21708749062016 @default.
• W2170874906 countsByYear W21708749062017 @default.
• W2170874906 countsByYear W21708749062018 @default.
• W2170874906 countsByYear W21708749062019 @default.
• W2170874906 countsByYear W21708749062020 @default.
• W2170874906 countsByYear W21708749062021 @default.
• W2170874906 countsByYear W21708749062022 @default.
• W2170874906 countsByYear W21708749062023 @default.
• W2170874906 crossrefType "journal-article" @default.
• W2170874906 hasAuthorship W2170874906A5026148404 @default.
• W2170874906 hasAuthorship W2170874906A5066432564 @default.
• W2170874906 hasAuthorship W2170874906A5069369769 @default.
• W2170874906 hasBestOaLocation W21708749062 @default.
• W2170874906 hasConcept C104317684 @default.
• W2170874906 hasConcept C132901563 @default.
• W2170874906 hasConcept C134651460 @default.
• W2170874906 hasConcept C181199279 @default.
• W2170874906 hasConcept C197957613 @default.
• W2170874906 hasConcept C2776317432 @default.
• W2170874906 hasConcept C2776878370 @default.
• W2170874906 hasConcept C2779123261 @default.
• W2170874906 hasConcept C547475151 @default.
• W2170874906 hasConcept C553450214 @default.
• W2170874906 hasConcept C55493867 @default.
• W2170874906 hasConcept C75520062 @default.
• W2170874906 hasConcept C86803240 @default.
• W2170874906 hasConceptScore W2170874906C104317684 @default.
• W2170874906 hasConceptScore W2170874906C132901563 @default.
• W2170874906 hasConceptScore W2170874906C134651460 @default.
• W2170874906 hasConceptScore W2170874906C181199279 @default.
• W2170874906 hasConceptScore W2170874906C197957613 @default.
• W2170874906 hasConceptScore W2170874906C2776317432 @default.
• W2170874906 hasConceptScore W2170874906C2776878370 @default.
• W2170874906 hasConceptScore W2170874906C2779123261 @default.
• W2170874906 hasConceptScore W2170874906C547475151 @default.
• W2170874906 hasConceptScore W2170874906C553450214 @default.
• W2170874906 hasConceptScore W2170874906C55493867 @default.
• W2170874906 hasConceptScore W2170874906C75520062 @default.
• W2170874906 hasConceptScore W2170874906C86803240 @default.
• W2170874906 hasIssue "13" @default.
• W2170874906 hasLocation W21708749061 @default.
• W2170874906 hasLocation W21708749062 @default.
• W2170874906 hasLocation W21708749063 @default.
• W2170874906 hasOpenAccess W2170874906 @default.
• W2170874906 hasPrimaryLocation W21708749061 @default.
• W2170874906 hasRelatedWork W107896380 @default.
• W2170874906 hasRelatedWork W134642770 @default.

• next