FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170875503> ?p ?o ?g. }

• W2170875503 endingPage "1404" @default.
• W2170875503 startingPage "1400" @default.
• W2170875503 abstract "Cholestasis is associated with systemic and hepatic oxidative and nitrosative stress; in this scenario, the conjugated hydrophilic bile salt ursodeoxycholate (UDCA) might play a protective role. Circulating oxidative and nitrosative stress markers were assessed in patients with primary biliary cirrhosis (PBC) before and during UDCA (15–20 mg/kg/day) therapy. In patients with stage I–II PBC, UDCA improved ALT and alkaline phosphatase levels and near normalized serum thioredoxin (1.97 ± 0.37 vs 2.41 ± 0.39 nmol/L), nitrotyrosine (15 ± 4 vs 22 ± 7 nmol/L), nitrosothiols (144 ± 28 vs 205 ± 84 nmol/L) and K-18 levels (162 ± 21 vs 228 ± 33 U/L). Conversely, less marked changes were noted in patients with stages III–IV who showed lower thioredoxin (1.01 ± 0.31 nmol/L), higher nitrosothiols (605 ± 64 nmol/L), nitrotyrosine (62 ± 13 nmol/L) and K-18 levels (521 ± 57 U/L). Overall, thioredoxin was inversely related with nitrotyrosine (r = − 0.838, P < 0.001) and K-18 (r = − 0.838, P < 0.001) levels. Nitrosothiols and K-18 were linearly and significantly related with nitrotyrosine (r = 0.862, P < 0.001; r = 0.894, P < 0.001, respectively). Oxidative and nitrosative changes in patients with PBC are effectively counteracted by UDCA. The protective effect of UDCA, however, are limited to early disease stages and progressively diminishes with ongoing cholestasis." @default.
• W2170875503 created "2016-06-24" @default.
• W2170875503 creator A5000041731 @default.
• W2170875503 creator A5046657664 @default.
• W2170875503 creator A5061634321 @default.
• W2170875503 creator A5088702595 @default.
• W2170875503 creator A5070737458 @default.
• W2170875503 date "2011-12-01" @default.
• W2170875503 modified "2023-09-24" @default.
• W2170875503 title "Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients" @default.
• W2170875503 cites W1551392207 @default.
• W2170875503 cites W160578699 @default.
• W2170875503 cites W1969315308 @default.
• W2170875503 cites W1980089776 @default.
• W2170875503 cites W1984065159 @default.
• W2170875503 cites W2004030501 @default.
• W2170875503 cites W2005205544 @default.
• W2170875503 cites W2007814093 @default.
• W2170875503 cites W2007888462 @default.
• W2170875503 cites W2010586937 @default.
• W2170875503 cites W2014944403 @default.
• W2170875503 cites W2040852689 @default.
• W2170875503 cites W2044168407 @default.
• W2170875503 cites W2047466663 @default.
• W2170875503 cites W2057479177 @default.
• W2170875503 cites W2060792031 @default.
• W2170875503 cites W2063078080 @default.
• W2170875503 cites W2066849422 @default.
• W2170875503 cites W2067106162 @default.
• W2170875503 cites W2068373649 @default.
• W2170875503 cites W2072623280 @default.
• W2170875503 cites W2079944080 @default.
• W2170875503 cites W2080656840 @default.
• W2170875503 cites W2082090750 @default.
• W2170875503 cites W2084822875 @default.
• W2170875503 cites W2088378615 @default.
• W2170875503 cites W2106174458 @default.
• W2170875503 cites W2106450793 @default.
• W2170875503 cites W2113612870 @default.
• W2170875503 cites W2139354826 @default.
• W2170875503 cites W2147298418 @default.
• W2170875503 cites W2162781734 @default.
• W2170875503 cites W4240215077 @default.
• W2170875503 cites W2102028016 @default.
• W2170875503 doi "https://doi.org/10.1016/j.clinbiochem.2011.09.008" @default.
• W2170875503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21963381" @default.
• W2170875503 hasPublicationYear "2011" @default.
• W2170875503 type Work @default.
• W2170875503 sameAs 2170875503 @default.
• W2170875503 citedByCount "14" @default.
• W2170875503 countsByYear W21708755032014 @default.
• W2170875503 countsByYear W21708755032015 @default.
• W2170875503 countsByYear W21708755032016 @default.
• W2170875503 countsByYear W21708755032017 @default.
• W2170875503 countsByYear W21708755032020 @default.
• W2170875503 countsByYear W21708755032021 @default.
• W2170875503 countsByYear W21708755032022 @default.
• W2170875503 crossrefType "journal-article" @default.
• W2170875503 hasAuthorship W2170875503A5000041731 @default.
• W2170875503 hasAuthorship W2170875503A5046657664 @default.
• W2170875503 hasAuthorship W2170875503A5061634321 @default.
• W2170875503 hasAuthorship W2170875503A5070737458 @default.
• W2170875503 hasAuthorship W2170875503A5088702595 @default.
• W2170875503 hasConcept C126322002 @default.
• W2170875503 hasConcept C134018914 @default.
• W2170875503 hasConcept C185592680 @default.
• W2170875503 hasConcept C2776151105 @default.
• W2170875503 hasConcept C2777622882 @default.
• W2170875503 hasConcept C2778593092 @default.
• W2170875503 hasConcept C2779385521 @default.
• W2170875503 hasConcept C2780366471 @default.
• W2170875503 hasConcept C2780965833 @default.
• W2170875503 hasConcept C3623737 @default.
• W2170875503 hasConcept C519581460 @default.
• W2170875503 hasConcept C55493867 @default.
• W2170875503 hasConcept C57600042 @default.
• W2170875503 hasConcept C71924100 @default.
• W2170875503 hasConceptScore W2170875503C126322002 @default.
• W2170875503 hasConceptScore W2170875503C134018914 @default.
• W2170875503 hasConceptScore W2170875503C185592680 @default.
• W2170875503 hasConceptScore W2170875503C2776151105 @default.
• W2170875503 hasConceptScore W2170875503C2777622882 @default.
• W2170875503 hasConceptScore W2170875503C2778593092 @default.
• W2170875503 hasConceptScore W2170875503C2779385521 @default.
• W2170875503 hasConceptScore W2170875503C2780366471 @default.
• W2170875503 hasConceptScore W2170875503C2780965833 @default.
• W2170875503 hasConceptScore W2170875503C3623737 @default.
• W2170875503 hasConceptScore W2170875503C519581460 @default.
• W2170875503 hasConceptScore W2170875503C55493867 @default.
• W2170875503 hasConceptScore W2170875503C57600042 @default.
• W2170875503 hasConceptScore W2170875503C71924100 @default.
• W2170875503 hasIssue "17-18" @default.
• W2170875503 hasLocation W21708755031 @default.
• W2170875503 hasLocation W21708755032 @default.
• W2170875503 hasOpenAccess W2170875503 @default.
• W2170875503 hasPrimaryLocation W21708755031 @default.
• W2170875503 hasRelatedWork W2008803377 @default.
• W2170875503 hasRelatedWork W2078883363 @default.

• next