FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170883762> ?p ?o ?g. }

• W2170883762 abstract "How exosomic microRNAs (miRNAs) contribute to the development of drug resistance in the context of the tumor microenvironment has not been previously described in neuroblastoma (NBL).Coculture experiments were performed to assess exosomic transfer of miR-21 from NBL cells to human monocytes and miR-155 from human monocytes to NBL cells. Luciferase reporter assays were performed to assess miR-155 targeting of TERF1 in NBL cells. Tumor growth was measured in NBL xenografts treated with Cisplatin and peritumoral exosomic miR-155 (n = 6 mice per group) CD163, miR-155, and TERF1 levels were assessed in 20 NBL primary tissues by Human Exon Arrays and quantitative real-time polymerase chain reaction. Student's t test was used to evaluate the differences between treatment groups. All statistical tests were two-sided.miR-21 mean fold change (f.c.) was 12.08±0.30 (P < .001) in human monocytes treated with NBL derived exosomes for 48 hours, and miR-155 mean f.c. was 4.51±0.25 (P < .001) in NBL cells cocultured with human monocytes for 48 hours. TERF1 mean luciferase activity in miR-155 transfected NBL cells normalized to scrambled was 0.36 ± 0.05 (P <.001). Mean tumor volumes in Dotap-miR-155 compared with Dotap-scrambled were 322.80±120mm(3) and 76.00±39.3mm(3), P = .002 at day 24, respectively. Patients with high CD163 infiltrating NBLs had statistically significantly higher intratumoral levels of miR-155 (P = .04) and lower levels of TERF1 mRNA (P = .02).These data indicate a unique role of exosomic miR-21 and miR-155 in the cross-talk between NBL cells and human monocytes in the resistance to chemotherapy, through a novel exosomic miR-21/TLR8-NF-кB/exosomic miR-155/TERF1 signaling pathway." @default.
• W2170883762 created "2016-06-24" @default.
• W2170883762 creator A5001658268 @default.
• W2170883762 creator A5008628156 @default.
• W2170883762 creator A5012394561 @default.
• W2170883762 creator A5013737134 @default.
• W2170883762 creator A5013938672 @default.
• W2170883762 creator A5021041349 @default.
• W2170883762 creator A5025604043 @default.
• W2170883762 creator A5027551885 @default.
• W2170883762 creator A5029836475 @default.
• W2170883762 creator A5044797595 @default.
• W2170883762 creator A5049622431 @default.
• W2170883762 creator A5057896638 @default.
• W2170883762 creator A5061158509 @default.
• W2170883762 creator A5067145358 @default.
• W2170883762 creator A5072661022 @default.
• W2170883762 creator A5075055655 @default.
• W2170883762 creator A5075828324 @default.
• W2170883762 creator A5080190143 @default.
• W2170883762 creator A5082498438 @default.
• W2170883762 creator A5090409397 @default.
• W2170883762 date "2015-05-13" @default.
• W2170883762 modified "2023-10-16" @default.
• W2170883762 title "Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy" @default.
• W2170883762 cites W1417342202 @default.
• W2170883762 cites W1762620449 @default.
• W2170883762 cites W1967139222 @default.
• W2170883762 cites W1969057487 @default.
• W2170883762 cites W1971030620 @default.
• W2170883762 cites W1979648944 @default.
• W2170883762 cites W1997338647 @default.
• W2170883762 cites W2028520651 @default.
• W2170883762 cites W2039652346 @default.
• W2170883762 cites W2044227662 @default.
• W2170883762 cites W2049772720 @default.
• W2170883762 cites W2053028783 @default.
• W2170883762 cites W2053197455 @default.
• W2170883762 cites W2055313665 @default.
• W2170883762 cites W2055904567 @default.
• W2170883762 cites W2057419005 @default.
• W2170883762 cites W2067606868 @default.
• W2170883762 cites W2067615930 @default.
• W2170883762 cites W2084770914 @default.
• W2170883762 cites W2086773784 @default.
• W2170883762 cites W2086809547 @default.
• W2170883762 cites W2089788088 @default.
• W2170883762 cites W2092349564 @default.
• W2170883762 cites W2095849686 @default.
• W2170883762 cites W2111733282 @default.
• W2170883762 cites W2114859007 @default.
• W2170883762 cites W2118776674 @default.
• W2170883762 cites W2119043140 @default.
• W2170883762 cites W2122421800 @default.
• W2170883762 cites W2122874141 @default.
• W2170883762 cites W2123105653 @default.
• W2170883762 cites W2125911029 @default.
• W2170883762 cites W2138983295 @default.
• W2170883762 cites W2142886333 @default.
• W2170883762 cites W2147266882 @default.
• W2170883762 cites W2147800896 @default.
• W2170883762 cites W2148846907 @default.
• W2170883762 cites W2150490516 @default.
• W2170883762 cites W2152420890 @default.
• W2170883762 cites W2156683768 @default.
• W2170883762 cites W2159999569 @default.
• W2170883762 cites W2164097016 @default.
• W2170883762 cites W2322168752 @default.
• W2170883762 cites W2412728867 @default.
• W2170883762 doi "https://doi.org/10.1093/jnci/djv135" @default.
• W2170883762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4651042" @default.
• W2170883762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972604" @default.
• W2170883762 hasPublicationYear "2015" @default.
• W2170883762 type Work @default.
• W2170883762 sameAs 2170883762 @default.
• W2170883762 citedByCount "274" @default.
• W2170883762 countsByYear W21708837622015 @default.
• W2170883762 countsByYear W21708837622016 @default.
• W2170883762 countsByYear W21708837622017 @default.
• W2170883762 countsByYear W21708837622018 @default.
• W2170883762 countsByYear W21708837622019 @default.
• W2170883762 countsByYear W21708837622020 @default.
• W2170883762 countsByYear W21708837622021 @default.
• W2170883762 countsByYear W21708837622022 @default.
• W2170883762 countsByYear W21708837622023 @default.
• W2170883762 crossrefType "journal-article" @default.
• W2170883762 hasAuthorship W2170883762A5001658268 @default.
• W2170883762 hasAuthorship W2170883762A5008628156 @default.
• W2170883762 hasAuthorship W2170883762A5012394561 @default.
• W2170883762 hasAuthorship W2170883762A5013737134 @default.
• W2170883762 hasAuthorship W2170883762A5013938672 @default.
• W2170883762 hasAuthorship W2170883762A5021041349 @default.
• W2170883762 hasAuthorship W2170883762A5025604043 @default.
• W2170883762 hasAuthorship W2170883762A5027551885 @default.
• W2170883762 hasAuthorship W2170883762A5029836475 @default.
• W2170883762 hasAuthorship W2170883762A5044797595 @default.
• W2170883762 hasAuthorship W2170883762A5049622431 @default.
• W2170883762 hasAuthorship W2170883762A5057896638 @default.
• W2170883762 hasAuthorship W2170883762A5061158509 @default.
• W2170883762 hasAuthorship W2170883762A5067145358 @default.

• next