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- W2170885013 abstract "Stage IV or wet stage IIIb non-small cell lung cancer (NSCLC) patients have improved survival by cisplatin-containing chemotherapy, but the magnitude of survival improvement is not precisely known and remains probably low. Due to the important toxicity (oto-, neuroand nephrotoxicity), alternative combinations are searched. The simplest alternative (carboplatin-based combinations) do not seem as effective as cisplatin-based chemotherapy (11% longer survival than carboplatin with the same agents) [1]. Other combinations of new agents have been studied. Among the different new anti-cancer agents, gemcitabine, paclitaxel, docetaxel, vinorelbine have interesting antitumour activity as single-agent chemotherapy. Patients receiving one of those drugs as a single-drug chemotherapy had longer survival than BSC-only treated patients [2–5]. The combination of platinum with one of the previously mentioned new drugs has demonstrated a higher response rate and survival when compared with the new drug alone [6]. The improvement can be compromised by increased toxicity, hence the rationale for testing non-platinum regimens as alternative therapy to the classical platinum-based combinations in advanced NSCLC." @default.
- W2170885013 created "2016-06-24" @default.
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- W2170885013 date "2006-05-01" @default.
- W2170885013 modified "2023-09-27" @default.
- W2170885013 title "Non-platinum combination of gemcitabine in NSCLC" @default.
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- W2170885013 doi "https://doi.org/10.1093/annonc/mdj957" @default.
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