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- W2170892256 abstract "Over a 100 years ago, William Bateson provided, through his observations of the transmission of alkaptonuria in first cousin offspring, evidence of the application of Mendelian genetics to certain human traits and diseases. His work was corroborated by Archibald Garrod (Archibald AE. The incidence of alkaptonuria: a study in chemical individuality. Lancert 1902;ii:1616-20) and William Farabee (Farabee WC. Inheritance of digital malformations in man. In: Papers of the Peabody Museum of American Archaeology and Ethnology. Cambridge, Mass: Harvard University, 1905; 65-78), who recorded the familial tendencies of inheritance of malformations of human hands and feet. These were the pioneers of the hunt for disease genes that would continue through the century and result in the discovery of hundreds of genes that can be associated with different diseases. Despite many ground-breaking discoveries during the last century, we are far from having a complete understanding of the intricate network of molecular processes involved in diseases, and we are still searching for the cures for most complex diseases. In the last few years, new genome sequencing and other high-throughput experimental techniques have generated vast amounts of molecular and clinical data that contain crucial information with the potential of leading to the next major biomedical discoveries. The need to mine, visualize and integrate these data has motivated the development of several informatics approaches that can broadly be grouped in the research area of 'translational bioinformatics'. This review highlights the latest advances in the field of translational bioinformatics, focusing on the advances of computational techniques to search for and classify disease genes." @default.
- W2170892256 created "2016-06-24" @default.
- W2170892256 creator A5013292761 @default.
- W2170892256 date "2009-12-10" @default.
- W2170892256 modified "2023-10-17" @default.
- W2170892256 title "Advances in translational bioinformatics: computational approaches for the hunting of disease genes" @default.
- W2170892256 cites W1484187172 @default.
- W2170892256 cites W1605637875 @default.
- W2170892256 cites W1872324379 @default.
- W2170892256 cites W1891078220 @default.
- W2170892256 cites W1979079649 @default.
- W2170892256 cites W1983728054 @default.
- W2170892256 cites W1983781571 @default.
- W2170892256 cites W1989684700 @default.
- W2170892256 cites W1999895438 @default.
- W2170892256 cites W2004928211 @default.
- W2170892256 cites W2005546833 @default.
- W2170892256 cites W2006654567 @default.
- W2170892256 cites W2009566741 @default.
- W2170892256 cites W2013221974 @default.
- W2170892256 cites W2014982561 @default.
- W2170892256 cites W2020301095 @default.
- W2170892256 cites W2021239799 @default.
- W2170892256 cites W2025670719 @default.
- W2170892256 cites W2032247293 @default.
- W2170892256 cites W2034936255 @default.
- W2170892256 cites W2036902495 @default.
- W2170892256 cites W2037535999 @default.
- W2170892256 cites W2038921819 @default.
- W2170892256 cites W2040827479 @default.
- W2170892256 cites W2046456909 @default.
- W2170892256 cites W2054991766 @default.
- W2170892256 cites W2063274819 @default.
- W2170892256 cites W2063448523 @default.
- W2170892256 cites W2064620468 @default.
- W2170892256 cites W2066614521 @default.
- W2170892256 cites W2070412833 @default.
- W2170892256 cites W2077973887 @default.
- W2170892256 cites W2080948989 @default.
- W2170892256 cites W2083045667 @default.
- W2170892256 cites W2083084071 @default.
- W2170892256 cites W2089535743 @default.
- W2170892256 cites W2089817566 @default.
- W2170892256 cites W2091579499 @default.
- W2170892256 cites W2094082417 @default.
- W2170892256 cites W2095956310 @default.
- W2170892256 cites W2096234478 @default.
- W2170892256 cites W2096410350 @default.
- W2170892256 cites W2096863518 @default.
- W2170892256 cites W2099656145 @default.
- W2170892256 cites W2100251770 @default.
- W2170892256 cites W2101897262 @default.
- W2170892256 cites W2103017472 @default.
- W2170892256 cites W2103543394 @default.
- W2170892256 cites W2104261859 @default.
- W2170892256 cites W2105813018 @default.
- W2170892256 cites W2107903949 @default.
- W2170892256 cites W2108181223 @default.
- W2170892256 cites W2109363337 @default.
- W2170892256 cites W2109372707 @default.
- W2170892256 cites W2109465247 @default.
- W2170892256 cites W2109555487 @default.
- W2170892256 cites W2112947018 @default.
- W2170892256 cites W2113962581 @default.
- W2170892256 cites W2115546496 @default.
- W2170892256 cites W2116484405 @default.
- W2170892256 cites W2116753165 @default.
- W2170892256 cites W2117446594 @default.
- W2170892256 cites W2117540545 @default.
- W2170892256 cites W2118413367 @default.
- W2170892256 cites W2118608964 @default.
- W2170892256 cites W2118864839 @default.
- W2170892256 cites W2119220491 @default.
- W2170892256 cites W2119371482 @default.
- W2170892256 cites W2119412782 @default.
- W2170892256 cites W2119907069 @default.
- W2170892256 cites W2119943416 @default.
- W2170892256 cites W2120051475 @default.
- W2170892256 cites W2120881407 @default.
- W2170892256 cites W2122732537 @default.
- W2170892256 cites W2123060905 @default.
- W2170892256 cites W2123775239 @default.
- W2170892256 cites W2124649657 @default.
- W2170892256 cites W2124873881 @default.
- W2170892256 cites W2125356853 @default.
- W2170892256 cites W2127981150 @default.
- W2170892256 cites W2128985829 @default.
- W2170892256 cites W2129682060 @default.
- W2170892256 cites W2130410032 @default.
- W2170892256 cites W2132056568 @default.
- W2170892256 cites W2133112449 @default.
- W2170892256 cites W2133219389 @default.
- W2170892256 cites W2133870323 @default.
- W2170892256 cites W2134711219 @default.
- W2170892256 cites W2135749526 @default.
- W2170892256 cites W2136078375 @default.
- W2170892256 cites W2137881949 @default.
- W2170892256 cites W2138155367 @default.