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• W2170897236 abstract "We investigated the cellular localization in the salamander retina of one of the somatostatin [or somatotropin release-inhibiting factor (SRIF)] receptors, sst 2A , and studied the modulatory action of SRIF on voltage-gated K + and Ca 2+ currents in rod and cone photoreceptors. SRIF immunostaining was observed in widely spaced amacrine cells, whose perikarya are at the border of the inner nuclear layer and inner plexiform layer. sst 2A immunostaining was seen in the inner segments and terminals of rod and cone photoreceptors. Additional sst 2A immunoreactivity was expressed by presumed bipolar and amacrine cells. SRIF, at concentrations of 100–500 n m , enhanced a delayed outwardly rectifying K + current ( I K ) in both rod and cone photoreceptors. SRIF action was blocked in cells pretreated with pertussis toxin (PTX) and was substantially reduced by intracellular GDP β S. Voltage-gated L-type Ca 2+ currents in rods and cones were differently modulated by SRIF. SRIF reduced Ca 2+ current in rods by 33% but increased it in cones by 40%, on average. Both effects were mediated via G-protein activation and blocked by PTX. Ca 2+ -imaging experiments supported these results by showing that 500 n m SRIF reduced a K + -induced increase in intracellular Ca 2+ in rod photoreceptor terminals but increased it in those of cones. Our results suggest that SRIF may play a role in the regulation of glutamate transmitter release from photoreceptors via modulation of voltage-gated K + and Ca 2+ currents." @default.
• W2170897236 created "2016-06-24" @default.
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• W2170897236 date "2000-02-01" @default.
• W2170897236 modified "2023-10-12" @default.
• W2170897236 title "Somatostatin Modulates Voltage-Gated K⁺and Ca²⁺Currents in Rod and Cone Photoreceptors of the Salamander Retina" @default.
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• W2170897236 doi "https://doi.org/10.1523/jneurosci.20-03-00929.2000" @default.
• W2170897236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696031" @default.
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