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• W2170899051 abstract "We conducted a phenotypic cDNA screening using a T cell line-based assay to identify human genes that render cells resistant to human immunodeficiency virus type 1 (HIV-1). We isolated potential HIV-1 resistance genes, including the carboxy terminal domain (CTD) of bromodomain-containing protein 4 (Brd4). Expression of GFP-Brd4-CTD was tolerated in MT-4 and Jurkat cells in which HIV-1 replication was markedly inhibited. We provide direct experimental data demonstrating that Brd4-CTD serves as a specific inhibitor of HIV-1 replication in T cells. Our method is a powerful tool for the identification of host factors that regulate HIV-1 replication in T cells." @default.
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• W2170899051 date "2008-11-07" @default.
• W2170899051 modified "2023-09-23" @default.
• W2170899051 title "Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells" @default.
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• W2170899051 doi "https://doi.org/10.1016/j.febslet.2008.10.047" @default.
• W2170899051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18996376" @default.
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