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• W2170899286 abstract "Transcription elongation is stimulated by positive transcription elongation factor b (P-TEFb), for which activity is repressed in the 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. We show here a critical role of 7SK snRNP in growth control of primordial germ cells (PGCs). The expression of p15 INK4b , a cyclin-dependent kinase inhibitor (CDKI) gene, in PGCs is selectively activated by P-TEFb and its recruiting molecule, Brd4, when the amount of active P-TEFb is increased due to reduction of the 7SK snRNP, and PGCs consequently undergo growth arrest. These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation." @default.
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• W2170899286 date "2012-11-15" @default.
• W2170899286 modified "2023-10-05" @default.
• W2170899286 title "Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells" @default.
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• W2170899286 doi "https://doi.org/10.1101/gad.202242.112" @default.
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