FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170911221> ?p ?o ?g. }

• W2170911221 abstract "Reactive oxygen species are an important mediator in isoflurane-induced myocardial preconditioning. However, hydroxyl radicals are also released during reperfusion after regional ischaemia. The purpose of the present study was to test whether ischaemic preconditioning and isoflurane would influence the production of hydroxyl radicals during reperfusion.After i.v. administration of salicylate 100 mg kg(-1) and a 30 min stabilization period, New Zealand White rabbits were subjected to 40 min of regional myocardial ischaemia and 2 h of reperfusion. Ischaemic preconditioning was elicited by 5 min ischaemia followed by 10 min reperfusion (before the 40 min ischaemia). In another group, isoflurane (2.1%) was administered for 30 min, followed by 15 min washout, before the long ischaemia. Area at risk and infarct size were assessed by blue dye injection and tetrazolium chloride staining. We quantified the level of OH-mediated conversion of salicylate to its dihydrobenzoate derivatives (2,3- and 2,5-DHBAs). Normalized values of the DHBAs (ng DHBA per mg salicylate) were calculated.Mean (se) infarct size was 57 (6)% of the risk area in the untreated controls. This was significantly smaller in the ischaemic preconditioning and isoflurane groups: 22 (5) and 23 (6)% respectively. At 10 min of reperfusion, ischaemic preconditioning limited the mean increase in 2,3-DHBA to 24% from baseline, compared with 81% in control and 74% in the isoflurane group. Normalized 2,5-DHBA was maximally increased by 75% in the untreated group, 4 min after reperfusion. Ischaemic preconditioning significantly inhibited this increase (24% increase from baseline, P<0.01). However, the increase observed in the isoflurane group was not different from control (71%).As already known, ischaemic preconditioning and isoflurane markedly reduced infarct size. However, only ischaemic preconditioning decreased postischaemic production of hydroxyl radicals. These different effects suggest different protective mechanisms at the cellular level." @default.
• W2170911221 created "2016-06-24" @default.
• W2170911221 creator A5021794237 @default.
• W2170911221 creator A5035492658 @default.
• W2170911221 creator A5042654562 @default.
• W2170911221 creator A5047524103 @default.
• W2170911221 creator A5055671277 @default.
• W2170911221 creator A5060705658 @default.
• W2170911221 date "2005-10-01" @default.
• W2170911221 modified "2023-10-11" @default.
• W2170911221 title "Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical production in the rabbit" @default.
• W2170911221 cites W2001719501 @default.
• W2170911221 cites W2008348367 @default.
• W2170911221 cites W2009624073 @default.
• W2170911221 cites W2010748153 @default.
• W2170911221 cites W2013371338 @default.
• W2170911221 cites W2020304693 @default.
• W2170911221 cites W2036817398 @default.
• W2170911221 cites W2040567517 @default.
• W2170911221 cites W2057548167 @default.
• W2170911221 cites W2058070380 @default.
• W2170911221 cites W2064235237 @default.
• W2170911221 cites W2077271970 @default.
• W2170911221 cites W2079438155 @default.
• W2170911221 cites W2081536165 @default.
• W2170911221 cites W2087776022 @default.
• W2170911221 cites W2091903932 @default.
• W2170911221 cites W2095984188 @default.
• W2170911221 cites W2105755265 @default.
• W2170911221 cites W2122521963 @default.
• W2170911221 cites W2124525232 @default.
• W2170911221 cites W2128432446 @default.
• W2170911221 cites W2130220177 @default.
• W2170911221 cites W2152260757 @default.
• W2170911221 cites W2160491292 @default.
• W2170911221 cites W2169166924 @default.
• W2170911221 cites W21827111 @default.
• W2170911221 doi "https://doi.org/10.1093/bja/aei203" @default.
• W2170911221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16040636" @default.
• W2170911221 hasPublicationYear "2005" @default.
• W2170911221 type Work @default.
• W2170911221 sameAs 2170911221 @default.
• W2170911221 citedByCount "0" @default.
• W2170911221 crossrefType "journal-article" @default.
• W2170911221 hasAuthorship W2170911221A5021794237 @default.
• W2170911221 hasAuthorship W2170911221A5035492658 @default.
• W2170911221 hasAuthorship W2170911221A5042654562 @default.
• W2170911221 hasAuthorship W2170911221A5047524103 @default.
• W2170911221 hasAuthorship W2170911221A5055671277 @default.
• W2170911221 hasAuthorship W2170911221A5060705658 @default.
• W2170911221 hasBestOaLocation W21709112211 @default.
• W2170911221 hasConcept C126322002 @default.
• W2170911221 hasConcept C139066938 @default.
• W2170911221 hasConcept C185592680 @default.
• W2170911221 hasConcept C2776359302 @default.
• W2170911221 hasConcept C2776390042 @default.
• W2170911221 hasConcept C2776778087 @default.
• W2170911221 hasConcept C2779311647 @default.
• W2170911221 hasConcept C42219234 @default.
• W2170911221 hasConcept C541997718 @default.
• W2170911221 hasConcept C55493867 @default.
• W2170911221 hasConcept C71924100 @default.
• W2170911221 hasConceptScore W2170911221C126322002 @default.
• W2170911221 hasConceptScore W2170911221C139066938 @default.
• W2170911221 hasConceptScore W2170911221C185592680 @default.
• W2170911221 hasConceptScore W2170911221C2776359302 @default.
• W2170911221 hasConceptScore W2170911221C2776390042 @default.
• W2170911221 hasConceptScore W2170911221C2776778087 @default.
• W2170911221 hasConceptScore W2170911221C2779311647 @default.
• W2170911221 hasConceptScore W2170911221C42219234 @default.
• W2170911221 hasConceptScore W2170911221C541997718 @default.
• W2170911221 hasConceptScore W2170911221C55493867 @default.
• W2170911221 hasConceptScore W2170911221C71924100 @default.
• W2170911221 hasLocation W21709112211 @default.
• W2170911221 hasLocation W21709112212 @default.
• W2170911221 hasOpenAccess W2170911221 @default.
• W2170911221 hasPrimaryLocation W21709112211 @default.
• W2170911221 hasRelatedWork W2038478739 @default.
• W2170911221 hasRelatedWork W2052728021 @default.
• W2170911221 hasRelatedWork W2170911221 @default.
• W2170911221 hasRelatedWork W2205239394 @default.
• W2170911221 hasRelatedWork W2347957821 @default.
• W2170911221 hasRelatedWork W2363157766 @default.
• W2170911221 hasRelatedWork W2386001980 @default.
• W2170911221 hasRelatedWork W2392368563 @default.
• W2170911221 hasRelatedWork W2412704372 @default.
• W2170911221 hasRelatedWork W2188060065 @default.
• W2170911221 isParatext "false" @default.
• W2170911221 isRetracted "false" @default.
• W2170911221 magId "2170911221" @default.
• W2170911221 workType "article" @default.