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• W2170924649 endingPage "6816" @default.
• W2170924649 startingPage "6811" @default.
• W2170924649 abstract "ABSTRACT When used as an immunogen, Treponema pallidum repeat protein K (TprK) has been shown to attenuate syphilitic lesions upon homologous intradermal challenge in the rabbit model. To further explore this protein as a potential vaccine component, we sought to identify the immunogenic regions of TprK. The abilities of three recombinant peptides encompassing TprK to elicit T- and B-cell responses and to protect against challenge were examined. All three fragments elicited proliferative responses from splenocytes taken from infected rabbits. However, enzyme-linked immunosorbent assays indicated that only fragments 1 and 3 were consistently recognized by antisera from infected rabbits. Each fragment was also used to immunize rabbits that were subsequently challenged intradermally with infectious T. pallidum . All lesions on unimmunized control rabbits ulcerated and contained treponemes, while the lesions on rabbits immunized with fragment 1 were the least likely to have detectable treponemes (25%) and the least likely to ulcerate (37.5%). The lesions on rabbits immunized with fragment 3 showed intermediate results, and rabbits immunized with fragment 2 were the most likely of all those on immunized rabbits to have detectable treponemes (91.7%) and to ulcerate (66.7%). These results demonstrate that epitopes in fragment 1 are recognized by T cells and antibodies during infection and that immunization with this portion of TprK most effectively attenuates syphilitic lesion development." @default.
• W2170924649 created "2016-06-24" @default.
• W2170924649 creator A5005944101 @default.
• W2170924649 creator A5032291355 @default.
• W2170924649 creator A5053928772 @default.
• W2170924649 date "2002-12-01" @default.
• W2170924649 modified "2023-10-16" @default.
• W2170924649 title "Immunization with the N-Terminal Portion of <i>Treponema pallidum</i> Repeat Protein K Attenuates Syphilitic Lesion Development in the Rabbit Model" @default.
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• W2170924649 doi "https://doi.org/10.1128/iai.70.12.6811-6816.2002" @default.
• W2170924649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133068" @default.
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