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• W2170930251 abstract "The mouse and human genomes contain 14 highly conserved <i>SLC39</i> genes. Viewed from an evolutionary perspective, <i>SLC39A14</i> and <i>SLC39A8</i> are the most closely related, each having three noncoding exons 1. However, <i>SLC39A14</i> has two exons 4, giving rise to Zrt- and Irt-related protein (ZIP)ZIP14A and ZIP14B alternatively spliced products. C57BL/6J mouse ZIP14A expression is highest in liver, duodenum, kidney, and testis; ZIP14B expression is highest in liver, duodenum, brain, and testis; and ZIP8 is highest in lung, testis, and kidney. We studied ZIP14 stably retroviral-infected mouse fetal fibroblast cultures and transiently transfected Madin-Darby canine kidney (MDCK) polarized epithelial cells. Our findings include: 1) ZIP14-mediated cadmium uptake is proportional to cell toxicity, but manganese is not; 2) ZIP14B has a higher affinity than ZIP14A toward Cd²⁺ (<i>K</i>_m = 0.14 versus 1.1 μM) and Mn²⁺ uptake (<i>K</i>_m = 4.4 versus 18.2 μM); 3) ZIP14A- and ZIP14B-mediated Cd²⁺ uptake is most inhibited by Zn²⁺, and next by Mn²⁺ and Cu²⁺; 4) like ZIP8, ZIP14A- and ZIP14B-mediated Cd²⁺ uptake is dependent on extracellular (mathrm{HCO}_{3}^{-}) ; 5) like ZIP8, ZIP14 transporters are localized on the apical surface of MDCK-ZIP cells; and 6) like ZIP8, ZIP14 proteins are glycosylated. Tissues such as intestine and liver, located between the environment and the animal, show high levels of ZIP14; given the high affinity for ZIP14, Cd²⁺ is likely to act as a rogue hitchhiker—displacing Zn²⁺ or Mn²⁺ and entering the body to cause unwanted cell damage and disease." @default.
• W2170930251 created "2016-06-24" @default.
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• W2170930251 date "2008-02-12" @default.
• W2170930251 modified "2023-10-15" @default.
• W2170930251 title "<i>Slc39a14</i> Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter" @default.
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• W2170930251 doi "https://doi.org/10.1124/mol.107.043588" @default.
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