FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170932122> ?p ?o ?g. }

• W2170932122 abstract "Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it rapidly and proficiently kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B. pahangi are morphologically and biologically similar, the Armigeres-Brugia system serves as a valuable model for studying the resistance mechanisms in mosquito vectors. We have initiated transcriptome profiling studies in Ar. subalbatus to identify molecular components involved in B. malayi refractoriness.These initial studies assessed the transcriptional response of Ar. subalbatus to B. malayi at 1, 3, 6, 12, 24, 48, and 72 hrs after an infective blood feed. In this investigation, we initiated the first holistic study conducted on the anti-filarial worm immune response in order to effectively explore the functional roles of immune-response genes following a natural exposure to the parasite. Studies assessing the transcriptional response revealed the involvement of unknown and conserved unknowns, cytoskeletal and structural components, and stress and immune responsive factors. The data show that the anti-filarial worm immune response by Ar. subalbatus to be a highly complex, tissue-specific process involving varied effector responses working in concert with blood cell-mediated melanization.This initial study provides a foundation and direction for future studies, which will more fully dissect the nature of the anti-filarial worm immune response in this mosquito-parasite system. The study also argues for continued studies with RNA generated from both hemocytes and whole bodies to fully expound the nature of the anti-filarial worm immune response." @default.
• W2170932122 created "2016-06-24" @default.
• W2170932122 creator A5003468882 @default.
• W2170932122 creator A5005834522 @default.
• W2170932122 creator A5012534121 @default.
• W2170932122 creator A5041160284 @default.
• W2170932122 creator A5070697792 @default.
• W2170932122 date "2007-12-01" @default.
• W2170932122 modified "2023-10-18" @default.
• W2170932122 title "Mosquito transcriptome changes and filarial worm resistance in Armigeres subalbatus" @default.
• W2170932122 cites W1584723402 @default.
• W2170932122 cites W1593349681 @default.
• W2170932122 cites W1601252917 @default.
• W2170932122 cites W1602781299 @default.
• W2170932122 cites W1964403279 @default.
• W2170932122 cites W1969545685 @default.
• W2170932122 cites W1970156673 @default.
• W2170932122 cites W1975523928 @default.
• W2170932122 cites W1977531463 @default.
• W2170932122 cites W1979128283 @default.
• W2170932122 cites W1989759946 @default.
• W2170932122 cites W1994181567 @default.
• W2170932122 cites W1998326708 @default.
• W2170932122 cites W2001419566 @default.
• W2170932122 cites W2005751717 @default.
• W2170932122 cites W2006820278 @default.
• W2170932122 cites W2006849849 @default.
• W2170932122 cites W2008884163 @default.
• W2170932122 cites W2015434639 @default.
• W2170932122 cites W2018271759 @default.
• W2170932122 cites W2032255555 @default.
• W2170932122 cites W2046711579 @default.
• W2170932122 cites W2061054199 @default.
• W2170932122 cites W2064003574 @default.
• W2170932122 cites W2065912508 @default.
• W2170932122 cites W2067385113 @default.
• W2170932122 cites W2068543945 @default.
• W2170932122 cites W2069407260 @default.
• W2170932122 cites W2072090415 @default.
• W2170932122 cites W2083358859 @default.
• W2170932122 cites W2084278560 @default.
• W2170932122 cites W2091075474 @default.
• W2170932122 cites W2094111164 @default.
• W2170932122 cites W2094344053 @default.
• W2170932122 cites W2102760505 @default.
• W2170932122 cites W2103178702 @default.
• W2170932122 cites W2104112516 @default.
• W2170932122 cites W2105218059 @default.
• W2170932122 cites W2107277218 @default.
• W2170932122 cites W2107450423 @default.
• W2170932122 cites W2107817332 @default.
• W2170932122 cites W2111362489 @default.
• W2170932122 cites W2118030557 @default.
• W2170932122 cites W2118292373 @default.
• W2170932122 cites W2122226340 @default.
• W2170932122 cites W2125912444 @default.
• W2170932122 cites W2127204035 @default.
• W2170932122 cites W2127924248 @default.
• W2170932122 cites W2132048031 @default.
• W2170932122 cites W2133111499 @default.
• W2170932122 cites W2133723917 @default.
• W2170932122 cites W2140113867 @default.
• W2170932122 cites W2142376475 @default.
• W2170932122 cites W2150197018 @default.
• W2170932122 cites W2151121679 @default.
• W2170932122 cites W2159147345 @default.
• W2170932122 cites W2159405964 @default.
• W2170932122 cites W2171419510 @default.
• W2170932122 cites W2312537902 @default.
• W2170932122 cites W2331907770 @default.
• W2170932122 cites W2507269450 @default.
• W2170932122 cites W4294216491 @default.
• W2170932122 doi "https://doi.org/10.1186/1471-2164-8-463" @default.
• W2170932122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2234435" @default.
• W2170932122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18088420" @default.
• W2170932122 hasPublicationYear "2007" @default.
• W2170932122 type Work @default.
• W2170932122 sameAs 2170932122 @default.
• W2170932122 citedByCount "30" @default.
• W2170932122 countsByYear W21709321222012 @default.
• W2170932122 countsByYear W21709321222013 @default.
• W2170932122 countsByYear W21709321222014 @default.
• W2170932122 countsByYear W21709321222015 @default.
• W2170932122 countsByYear W21709321222017 @default.
• W2170932122 countsByYear W21709321222018 @default.
• W2170932122 countsByYear W21709321222019 @default.
• W2170932122 countsByYear W21709321222020 @default.
• W2170932122 countsByYear W21709321222021 @default.
• W2170932122 countsByYear W21709321222023 @default.
• W2170932122 crossrefType "journal-article" @default.
• W2170932122 hasAuthorship W2170932122A5003468882 @default.
• W2170932122 hasAuthorship W2170932122A5005834522 @default.
• W2170932122 hasAuthorship W2170932122A5012534121 @default.
• W2170932122 hasAuthorship W2170932122A5041160284 @default.
• W2170932122 hasAuthorship W2170932122A5070697792 @default.
• W2170932122 hasBestOaLocation W21709321221 @default.
• W2170932122 hasConcept C104317684 @default.
• W2170932122 hasConcept C136449434 @default.
• W2170932122 hasConcept C136764020 @default.
• W2170932122 hasConcept C150194340 @default.

• next