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• W2170936621 abstract "Immune cell-mediated destruction of pathogens may result in excessive collateral damage to normal tissues, and the failure to control activated immune cells may cause immunopathologies. The search for physiological mechanisms that downregulate activated immune cells has revealed a critical role for extracellular adenosine and for immunosuppressive A2A adenosine receptors in protecting tissue from inflammatory damage. Tissue damage-associated deep hypoxia, hypoxia-inducible factors, and hypoxia-induced accumulation of adenosine may represent one of the most fundamental and immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering OFF signals in activated immune cells. In these regulatory mechanisms, oxygen deprivation and extracellular adenosine accumulation serve as reporters, while A2A adenosine receptors serve as sensors of excessive tissue damage. The A2A receptor-triggered generation of intracellular cAMP then inhibits activated immune cells in a delayed negative feedback manner to prevent additional tissue damage. Targeting A2A adenosine receptors may have important clinical applications." @default.
• W2170936621 created "2016-06-24" @default.
• W2170936621 creator A5004847358 @default.
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• W2170936621 creator A5088254641 @default.
• W2170936621 date "2004-04-01" @default.
• W2170936621 modified "2023-10-10" @default.
• W2170936621 title "P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A_2AR<scp>eceptors</scp>" @default.
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