Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170950003> ?p ?o ?g. }
- W2170950003 endingPage "1476" @default.
- W2170950003 startingPage "1468" @default.
- W2170950003 abstract "New Findings What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, ‘omics’. What advances does it highlight? Physiological studies have recently shed light on the myometrium in twin pregnancies, but there have been no ‘omic’ approaches. In contrast, studies of preterm delivery using newer approaches are generating new research avenues, whereas traditional approaches have not flourished. Finally, I describe significant advances in understanding of ‘slow‐to‐progress’ labours, achieved using physiological and clinical approaches. Advances in molecular, genetic and ‘omic’ technologies are fuelling the thirst for better understanding of the uterus and application of this information to problems in pregnancy and labour. Progress has, however, been limited while we still have an incomplete understanding of some of the basic physiology of uterine smooth muscle (myometrium). In this review and opinion piece, I explore some of the fascinating findings from selected recent studies and see how these may provide new avenues for physiological and clinical research. It is also the case, however, that there is still limited mechanistic understanding about physiological and pathophysiological processes in the myometrium. This lack of understanding limits the usefulness of some findings from genomic and allied studies. By focusing on some key recent findings and relating these to two important clinical problems in childbirth that involve myometrial activity, namely preterm delivery and difficult labours, the interplay between our physiological knowledge and the information provided by newer technologies is explored. My opinion is that physiology has provided much more new mechanistic insight into difficult births and that the newer technologies may lead to breakthroughs in preterm birth research, but that this has not yet happened." @default.
- W2170950003 created "2016-06-24" @default.
- W2170950003 creator A5028975429 @default.
- W2170950003 date "2015-09-13" @default.
- W2170950003 modified "2023-10-18" @default.
- W2170950003 title "Insights from physiology into myometrial function and dysfunction" @default.
- W2170950003 cites W1499287650 @default.
- W2170950003 cites W1780779628 @default.
- W2170950003 cites W1838862255 @default.
- W2170950003 cites W1940379475 @default.
- W2170950003 cites W1965242932 @default.
- W2170950003 cites W1967022821 @default.
- W2170950003 cites W1970338647 @default.
- W2170950003 cites W1971943511 @default.
- W2170950003 cites W1974929975 @default.
- W2170950003 cites W1976383760 @default.
- W2170950003 cites W1981927147 @default.
- W2170950003 cites W1989949458 @default.
- W2170950003 cites W1990217946 @default.
- W2170950003 cites W1991857522 @default.
- W2170950003 cites W1996642244 @default.
- W2170950003 cites W1999600775 @default.
- W2170950003 cites W2006756396 @default.
- W2170950003 cites W2007677103 @default.
- W2170950003 cites W2014960263 @default.
- W2170950003 cites W2015147099 @default.
- W2170950003 cites W2018455478 @default.
- W2170950003 cites W2027995119 @default.
- W2170950003 cites W2028800247 @default.
- W2170950003 cites W2030005109 @default.
- W2170950003 cites W2032125562 @default.
- W2170950003 cites W2035562131 @default.
- W2170950003 cites W2035992043 @default.
- W2170950003 cites W2041502959 @default.
- W2170950003 cites W2042358895 @default.
- W2170950003 cites W2042750677 @default.
- W2170950003 cites W2053324779 @default.
- W2170950003 cites W2054304414 @default.
- W2170950003 cites W2058212817 @default.
- W2170950003 cites W2060961853 @default.
- W2170950003 cites W2063627864 @default.
- W2170950003 cites W2066219233 @default.
- W2170950003 cites W2074130440 @default.
- W2170950003 cites W2079988812 @default.
- W2170950003 cites W2080832092 @default.
- W2170950003 cites W2084893329 @default.
- W2170950003 cites W2100720343 @default.
- W2170950003 cites W2104250249 @default.
- W2170950003 cites W2104527263 @default.
- W2170950003 cites W2111304173 @default.
- W2170950003 cites W2117191959 @default.
- W2170950003 cites W2123594267 @default.
- W2170950003 cites W2130191713 @default.
- W2170950003 cites W2135013643 @default.
- W2170950003 cites W2138487576 @default.
- W2170950003 cites W2143018909 @default.
- W2170950003 cites W2151139128 @default.
- W2170950003 cites W2151386873 @default.
- W2170950003 cites W2153119256 @default.
- W2170950003 cites W2153327828 @default.
- W2170950003 cites W2153784336 @default.
- W2170950003 cites W2156123381 @default.
- W2170950003 cites W2159175629 @default.
- W2170950003 cites W2162581294 @default.
- W2170950003 cites W2169278993 @default.
- W2170950003 cites W2171374888 @default.
- W2170950003 cites W2059828180 @default.
- W2170950003 doi "https://doi.org/10.1113/ep085131" @default.
- W2170950003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26289390" @default.
- W2170950003 hasPublicationYear "2015" @default.
- W2170950003 type Work @default.
- W2170950003 sameAs 2170950003 @default.
- W2170950003 citedByCount "29" @default.
- W2170950003 countsByYear W21709500032015 @default.
- W2170950003 countsByYear W21709500032016 @default.
- W2170950003 countsByYear W21709500032017 @default.
- W2170950003 countsByYear W21709500032018 @default.
- W2170950003 countsByYear W21709500032019 @default.
- W2170950003 countsByYear W21709500032020 @default.
- W2170950003 countsByYear W21709500032021 @default.
- W2170950003 countsByYear W21709500032022 @default.
- W2170950003 countsByYear W21709500032023 @default.
- W2170950003 crossrefType "journal-article" @default.
- W2170950003 hasAuthorship W2170950003A5028975429 @default.
- W2170950003 hasBestOaLocation W21709500031 @default.
- W2170950003 hasConcept C169760540 @default.
- W2170950003 hasConcept C2778164554 @default.
- W2170950003 hasConcept C2779234561 @default.
- W2170950003 hasConcept C42407357 @default.
- W2170950003 hasConcept C54355233 @default.
- W2170950003 hasConcept C60644358 @default.
- W2170950003 hasConcept C71924100 @default.
- W2170950003 hasConcept C86803240 @default.
- W2170950003 hasConceptScore W2170950003C169760540 @default.
- W2170950003 hasConceptScore W2170950003C2778164554 @default.
- W2170950003 hasConceptScore W2170950003C2779234561 @default.
- W2170950003 hasConceptScore W2170950003C42407357 @default.
- W2170950003 hasConceptScore W2170950003C54355233 @default.