FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170953038> ?p ?o ?g. }

• W2170953038 endingPage "S141" @default.
• W2170953038 startingPage "S126" @default.
• W2170953038 abstract "The macrocyclic ketone (MK) group of fragrance ingredients was evaluated for safety following a complete literature search. For high end users, calculated maximum dermal exposures vary from 0.13% to 1.10%; systemic exposures vary from 0.0005 to 0.0441 mg/kg/day. The MKs had low acute toxicity and no significant repeat dose toxicity. Liver weight and blood biochemistry effects were reversible after 2 weeks. No genotoxicity in bacteria and mammalian cell lines was observed. Reproductive toxicity was not observed for 3-methylcyclopentadecenone in an OECD compliant study. In humans, MKs are generally not irritating after one application. Animal studies showed irritation for some materials at concentrations higher than current consumer exposure. At rates consistent with current human exposure, phototoxicity and photosensitization were not observed. In animals, some MKs are sensitizers only at concentrations of 20%, 30%, or 100%, which are higher than current consumer exposure. No evidence of sensitization was observed in human tests. In patients with fragrance allergy, reactions were seen with cyclopentadecanone (3/178). Based on these findings, the Panel is of the opinion that there are no safety concerns for the MKs at reported levels of use and exposure as fragrance ingredients." @default.
• W2170953038 created "2016-06-24" @default.
• W2170953038 creator A5012629222 @default.
• W2170953038 creator A5014865981 @default.
• W2170953038 creator A5035988449 @default.
• W2170953038 creator A5044522566 @default.
• W2170953038 creator A5045971759 @default.
• W2170953038 creator A5049902752 @default.
• W2170953038 creator A5062581638 @default.
• W2170953038 creator A5074547704 @default.
• W2170953038 creator A5076875729 @default.
• W2170953038 creator A5080862260 @default.
• W2170953038 date "2011-12-01" @default.
• W2170953038 modified "2023-10-16" @default.
• W2170953038 title "A toxicological and dermatological assessment of macrocyclic ketones when used as fragrance ingredients" @default.
• W2170953038 cites W1965366194 @default.
• W2170953038 cites W1970478449 @default.
• W2170953038 cites W1974395809 @default.
• W2170953038 cites W1975560106 @default.
• W2170953038 cites W1999517272 @default.
• W2170953038 cites W2002856707 @default.
• W2170953038 cites W2011768452 @default.
• W2170953038 cites W2029105509 @default.
• W2170953038 cites W2029534266 @default.
• W2170953038 cites W2081274951 @default.
• W2170953038 cites W2082059576 @default.
• W2170953038 cites W2131893332 @default.
• W2170953038 cites W2159515071 @default.
• W2170953038 cites W2160272611 @default.
• W2170953038 cites W2160281157 @default.
• W2170953038 cites W4236969903 @default.
• W2170953038 cites W4250182805 @default.
• W2170953038 doi "https://doi.org/10.1016/j.fct.2011.07.040" @default.
• W2170953038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24246175" @default.
• W2170953038 hasPublicationYear "2011" @default.
• W2170953038 type Work @default.
• W2170953038 sameAs 2170953038 @default.
• W2170953038 citedByCount "21" @default.
• W2170953038 countsByYear W21709530382015 @default.
• W2170953038 countsByYear W21709530382016 @default.
• W2170953038 countsByYear W21709530382017 @default.
• W2170953038 countsByYear W21709530382019 @default.
• W2170953038 countsByYear W21709530382022 @default.
• W2170953038 countsByYear W21709530382023 @default.
• W2170953038 crossrefType "journal-article" @default.
• W2170953038 hasAuthorship W2170953038A5012629222 @default.
• W2170953038 hasAuthorship W2170953038A5014865981 @default.
• W2170953038 hasAuthorship W2170953038A5035988449 @default.
• W2170953038 hasAuthorship W2170953038A5044522566 @default.
• W2170953038 hasAuthorship W2170953038A5045971759 @default.
• W2170953038 hasAuthorship W2170953038A5049902752 @default.
• W2170953038 hasAuthorship W2170953038A5062581638 @default.
• W2170953038 hasAuthorship W2170953038A5074547704 @default.
• W2170953038 hasAuthorship W2170953038A5076875729 @default.
• W2170953038 hasAuthorship W2170953038A5080862260 @default.
• W2170953038 hasConcept C16005928 @default.
• W2170953038 hasConcept C178790620 @default.
• W2170953038 hasConcept C185592680 @default.
• W2170953038 hasConcept C202751555 @default.
• W2170953038 hasConcept C203014093 @default.
• W2170953038 hasConcept C20639190 @default.
• W2170953038 hasConcept C2776217527 @default.
• W2170953038 hasConcept C2777063393 @default.
• W2170953038 hasConcept C2778959862 @default.
• W2170953038 hasConcept C29730261 @default.
• W2170953038 hasConcept C33070731 @default.
• W2170953038 hasConcept C42407357 @default.
• W2170953038 hasConcept C55493867 @default.
• W2170953038 hasConcept C71924100 @default.
• W2170953038 hasConcept C86803240 @default.
• W2170953038 hasConcept C98274493 @default.
• W2170953038 hasConcept C99432707 @default.
• W2170953038 hasConceptScore W2170953038C16005928 @default.
• W2170953038 hasConceptScore W2170953038C178790620 @default.
• W2170953038 hasConceptScore W2170953038C185592680 @default.
• W2170953038 hasConceptScore W2170953038C202751555 @default.
• W2170953038 hasConceptScore W2170953038C203014093 @default.
• W2170953038 hasConceptScore W2170953038C20639190 @default.
• W2170953038 hasConceptScore W2170953038C2776217527 @default.
• W2170953038 hasConceptScore W2170953038C2777063393 @default.
• W2170953038 hasConceptScore W2170953038C2778959862 @default.
• W2170953038 hasConceptScore W2170953038C29730261 @default.
• W2170953038 hasConceptScore W2170953038C33070731 @default.
• W2170953038 hasConceptScore W2170953038C42407357 @default.
• W2170953038 hasConceptScore W2170953038C55493867 @default.
• W2170953038 hasConceptScore W2170953038C71924100 @default.
• W2170953038 hasConceptScore W2170953038C86803240 @default.
• W2170953038 hasConceptScore W2170953038C98274493 @default.
• W2170953038 hasConceptScore W2170953038C99432707 @default.
• W2170953038 hasLocation W21709530381 @default.
• W2170953038 hasLocation W21709530382 @default.
• W2170953038 hasOpenAccess W2170953038 @default.
• W2170953038 hasPrimaryLocation W21709530381 @default.
• W2170953038 hasRelatedWork W1977393998 @default.
• W2170953038 hasRelatedWork W2006023412 @default.
• W2170953038 hasRelatedWork W2210666292 @default.
• W2170953038 hasRelatedWork W2321111252 @default.
• W2170953038 hasRelatedWork W2478669159 @default.

• next