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• W2170969288 abstract "Bacillus subtilis 6S-1 RNA binds to the housekeeping RNA polymerase (σ(A)-RNAP) and directs transcription of short 'product' RNAs (pRNAs). Here, we demonstrate that once newly synthesized pRNAs form a sufficiently stable duplex with 6S-1 RNA, a structural rearrangement is induced in cis, which involves base-pairing between sequences in the 5'-portion of the central bulge and nucleotides that become available as a result of pRNA invasion. The rearrangement decreases 6S-1 RNA affinity for σ(A)-RNAP. Among the pRNA length variants synthesized by σ(A)-RNAP (up to ∼14 nt), only the longer ones, such as 12-14-mers, form a duplex with 6S-1 RNA that is sufficiently long-lived to induce the rearrangement. Yet, an LNA (locked nucleic acid) 8-mer can induce the same rearrangement due to conferring increased duplex stability. We propose that an interplay of rate constants for polymerization (k(pol)), for pRNA:6S-1 RNA hybrid duplex dissociation (k(off)) and for the rearrangement (k(conf)) determines whether pRNAs dissociate or rearrange 6S-1 structure to trigger 6S-1 RNA release from σ(A)-RNAP. A bioinformatic screen suggests that essentially all bacterial 6S RNAs have the potential to undergo a pRNA-induced structural rearrangement." @default.
• W2170969288 created "2016-06-24" @default.
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• W2170969288 date "2012-02-14" @default.
• W2170969288 modified "2023-10-01" @default.
• W2170969288 title "A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in<i>Bacillus subtilis</i>" @default.
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• W2170969288 doi "https://doi.org/10.1038/emboj.2012.23" @default.
• W2170969288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3321203" @default.
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