Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170976692> ?p ?o ?g. }
- W2170976692 endingPage "1600" @default.
- W2170976692 startingPage "1591" @default.
- W2170976692 abstract "P-cadherin serves as a major topobiological cue in mammalian epithelium. In human hair follicles (HFs), it is prominently expressed in the inner hair matrix that harbors the HF pigmentary unit. However, the role of P-cadherin in normal human pigmentation remains unknown. As patients with mutations in the gene that encodes P-cadherin show hypotrichosis and fair hair, we explored the hypothesis that P-cadherin may control HF pigmentation. When P-cadherin was silenced in melanogenically active organ-cultured human scalp HFs, this significantly reduced HF melanogenesis and tyrosinase activity as well as gene and/or protein expression of gp100, stem cell factor, c-Kit, and microphthalmia-associated transcription factor (MITF), both in situ and in isolated human HF melanocytes. Instead, epidermal pigmentation was unaffected by P-cadherin knockdown in organ-cultured human skin. In hair matrix keratinocytes, P-cadherin silencing reduced plasma membrane β-catenin, whereas glycogen synthase kinase 3 beta (GSK3β) and phospho-β-catenin expression were significantly upregulated. This suggests that P-cadherin-GSK3β/Wnt signaling is required for maintaining the expression of MITF to sustain intrafollicular melanogenesis. Thus, P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3β-mediated canonical Wnt signaling." @default.
- W2170976692 created "2016-06-24" @default.
- W2170976692 creator A5009477818 @default.
- W2170976692 creator A5016106271 @default.
- W2170976692 creator A5047766100 @default.
- W2170976692 creator A5050718731 @default.
- W2170976692 creator A5065985125 @default.
- W2170976692 creator A5071800466 @default.
- W2170976692 creator A5079802097 @default.
- W2170976692 creator A5081158534 @default.
- W2170976692 creator A5082322510 @default.
- W2170976692 date "2013-06-01" @default.
- W2170976692 modified "2023-10-15" @default.
- W2170976692 title "Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis" @default.
- W2170976692 cites W1504076602 @default.
- W2170976692 cites W1517916845 @default.
- W2170976692 cites W1524415778 @default.
- W2170976692 cites W1554126164 @default.
- W2170976692 cites W1611895582 @default.
- W2170976692 cites W1657719429 @default.
- W2170976692 cites W1709944091 @default.
- W2170976692 cites W172875853 @default.
- W2170976692 cites W1894414578 @default.
- W2170976692 cites W1956332901 @default.
- W2170976692 cites W1963091570 @default.
- W2170976692 cites W1963652662 @default.
- W2170976692 cites W1977096185 @default.
- W2170976692 cites W1981752846 @default.
- W2170976692 cites W1985688210 @default.
- W2170976692 cites W1990006711 @default.
- W2170976692 cites W1995508961 @default.
- W2170976692 cites W1996067072 @default.
- W2170976692 cites W1996545028 @default.
- W2170976692 cites W2002811027 @default.
- W2170976692 cites W2002918515 @default.
- W2170976692 cites W2004519386 @default.
- W2170976692 cites W2006147360 @default.
- W2170976692 cites W2006338705 @default.
- W2170976692 cites W2006435611 @default.
- W2170976692 cites W2010050195 @default.
- W2170976692 cites W2010098391 @default.
- W2170976692 cites W2010233517 @default.
- W2170976692 cites W2010601015 @default.
- W2170976692 cites W2017807559 @default.
- W2170976692 cites W2020645580 @default.
- W2170976692 cites W2020709644 @default.
- W2170976692 cites W2020746567 @default.
- W2170976692 cites W2021443187 @default.
- W2170976692 cites W2024815096 @default.
- W2170976692 cites W2029167978 @default.
- W2170976692 cites W2032863484 @default.
- W2170976692 cites W2032981041 @default.
- W2170976692 cites W2041453299 @default.
- W2170976692 cites W2043581327 @default.
- W2170976692 cites W2043758773 @default.
- W2170976692 cites W2051786138 @default.
- W2170976692 cites W2055972315 @default.
- W2170976692 cites W2057343238 @default.
- W2170976692 cites W2059656320 @default.
- W2170976692 cites W2060600354 @default.
- W2170976692 cites W2063423234 @default.
- W2170976692 cites W2063530810 @default.
- W2170976692 cites W2069279803 @default.
- W2170976692 cites W2069799770 @default.
- W2170976692 cites W2072657606 @default.
- W2170976692 cites W2074951823 @default.
- W2170976692 cites W2076379612 @default.
- W2170976692 cites W2080149190 @default.
- W2170976692 cites W2083382694 @default.
- W2170976692 cites W2088130063 @default.
- W2170976692 cites W2088956647 @default.
- W2170976692 cites W2098218273 @default.
- W2170976692 cites W2098763910 @default.
- W2170976692 cites W2100409705 @default.
- W2170976692 cites W2111334492 @default.
- W2170976692 cites W2118031242 @default.
- W2170976692 cites W2120118094 @default.
- W2170976692 cites W2122441130 @default.
- W2170976692 cites W2133141150 @default.
- W2170976692 cites W2136308004 @default.
- W2170976692 cites W2144200294 @default.
- W2170976692 cites W2148294117 @default.
- W2170976692 cites W2160776258 @default.
- W2170976692 cites W2162997202 @default.
- W2170976692 cites W2168147961 @default.
- W2170976692 cites W2317089590 @default.
- W2170976692 cites W2342443123 @default.
- W2170976692 cites W2343997548 @default.
- W2170976692 cites W4231001706 @default.
- W2170976692 doi "https://doi.org/10.1038/jid.2013.18" @default.
- W2170976692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23334344" @default.
- W2170976692 hasPublicationYear "2013" @default.
- W2170976692 type Work @default.
- W2170976692 sameAs 2170976692 @default.
- W2170976692 citedByCount "27" @default.
- W2170976692 countsByYear W21709766922014 @default.
- W2170976692 countsByYear W21709766922015 @default.
- W2170976692 countsByYear W21709766922016 @default.