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• W2170983268 abstract "For the first 10 days of pregnancy and the first 12 days of pseudopregnancy, the secretion of prolactin (PRL) from pituitary lactotrophs is rhythmic, with two surges/day. This rhythm can also be triggered by bolus injection of oxytocin (OT). We describe a mathematical model for the initiation, maintenance, and termination of the OT-induced PRL rhythm. In our model, the mechanism for this circadian rhythm is mutual interaction between lactotrophs and neuroendocrine dopamine (DA) neurons. This rhythm is, under normal lighting conditions, entrained by the suprachiasmatic nucleus (SCN) but persists in the absence of input from the SCN. We postulate that OT injection triggers the rhythm by activating a population of bistable hypothalamic neurons that innervate and inhibit DA neurons. The bistable nature of these neurons allows them to act as a memory device, maintaining the rhythm long after OT has been cleared from the blood. The mechanism for this memory device and the arguments supporting it are detailed with computer simulations. Finally, we consider potential targets for a rhythm-terminating factor and make predictions that may be used to determine which mechanism is operational in terminating the OT- or mating-induced PRL rhythm." @default.
• W2170983268 created "2016-06-24" @default.
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• W2170983268 date "2006-03-01" @default.
• W2170983268 modified "2023-10-16" @default.
• W2170983268 title "A mathematical model for the mating-induced prolactin rhythm of female rats" @default.
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• W2170983268 doi "https://doi.org/10.1152/ajpendo.00428.2005" @default.
• W2170983268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1543714" @default.
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• W2170983268 hasPublicationYear "2006" @default.
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