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- W2170986006 abstract "The transport of the photopigment rhodopsin from the inner segment to the photosensitive outer segment of vertebrate photoreceptor cells has been one of the main remaining mysteries in photoreceptor cell biology. Because of the lack of any direct evidence for the pathway through the photoreceptor cilium, alternative extracellular pathways have been proposed. Our primary aim in the present study was to resolve rhodopsin trafficking from the inner to the outer segment. We demonstrate, predominantly by high-sensitive immunoelectron microscopy, that rhodopsin is also densely packed in the membrane of the photoreceptor connecting cilium. Present prominent labeling of rhodopsin in the ciliary membrane provides the first striking evidence that rhodopsin is translocated from the inner segment to the outer segment of wild type photoreceptors via the ciliary membrane. At the ciliary membrane rhodopsin co-localizes with the unconventional myosin VIIa, the product of human Usher syndrome 1B gene. Furthermore, axonemal actin was identified in the photoreceptor cilium, which is spatially co-localized with myosin VIIa and opsin. This actin cytoskeleton of the cilium may provide the structural bases for myosin VIIa-linked ciliary trafficking of membrane components, including rhodopsin." @default.
- W2170986006 created "2016-06-24" @default.
- W2170986006 creator A5044276564 @default.
- W2170986006 creator A5084222497 @default.
- W2170986006 date "2000-01-01" @default.
- W2170986006 modified "2023-10-09" @default.
- W2170986006 title "Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells" @default.
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- W2170986006 doi "https://doi.org/10.1002/1097-0169(200006)46:2<95::aid-cm2>3.0.co;2-q" @default.
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