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- W2171010446 abstract "Zerumbone (ZER), a bioactive compound isolated from Zingiber zerumbet Smith, was examined for single and repeated-dose toxicity at dosages with antitumor effects on imprinting control regions (ICR) mice and mice of either sex for repeated dose, respectively. For the single dose toxicity study, ZER was administrated to ICR mice at a dose of 500 mg/kg via intraperitoneal injection, while for the repeated dose toxicity study, mice of either sex were studied at dosages of 5, 25 and 50 mg/kg for a period of 28 days. The effects on body and organ weight, food and water consumption, hematology, serum biochemistry as well as histology, were evaluated. No mortality or significant changes in the clinical signs were produced at the single dose toxicity. There were no significant differences in the general condition, growth, organ weights, hematology, serum biochemistry, or histopathological analysis in the repeated dose toxicity as well. These results suggest that ZER is safe in a toxicity study for the cancer treatment in mice regardless of whether male or female mice. Key words: Zerumbone, toxicity, antitumor effect, single and repeated dose, safety." @default.
- W2171010446 created "2016-06-24" @default.
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- W2171010446 date "2013-02-28" @default.
- W2171010446 modified "2023-10-02" @default.
- W2171010446 title "Toxicological evaluation of zerumbone on antitumor effects in mice" @default.
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- W2171010446 doi "https://doi.org/10.5897/ajpp2012.0001" @default.
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