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- W2171010912 endingPage "2873" @default.
- W2171010912 startingPage "2865" @default.
- W2171010912 abstract "ABSTRACT Mutations in rRNA genes ( rrn ) that confer resistance to ribosomal inhibitors are typically recessive or weakly codominant and have been mostly reported for clinical strains of pathogens possessing only one or two rrn operons, such as Helicobacter pylori and Mycobacterium spp. An analysis of the genome sequences of several members of the Chlamydiaceae revealed that these obligate intracellular bacteria harbor only one or two sets of rRNA genes. To study the contribution of rRNA mutations to the emergence of drug resistance in the Chlamydiaceae , we used the sensitivities of Chlamydia trachomatis L2 (two rrn operons) and Chlamydophila psittaci 6BC (one rrn operon) to the aminoglycoside spectinomycin as a model. Confluent cell monolayers were infected in a plaque assay with about 10 8 wild-type infectious particles and then treated with the antibiotic. After a 2-week incubation time, plaques formed by spontaneous spectinomycin-resistant (Spc r ) mutants appeared with a frequency of 5 × 10 −5 for C. psittaci 6BC. No Spc r mutants were isolated for C. trachomatis L2, although the frequencies of rifampin resistance were in the same range for both strains (i.e., 10 −7 ). The risk of emergence of Chlamydia strains resistant to tetracyclines and macrolides, the ribosomal drugs currently used to treat chlamydial infections, is discussed." @default.
- W2171010912 created "2016-06-24" @default.
- W2171010912 creator A5026573261 @default.
- W2171010912 creator A5041229465 @default.
- W2171010912 date "2005-07-01" @default.
- W2171010912 modified "2023-09-27" @default.
- W2171010912 title "Frequency of Spontaneous Mutations That Confer Antibiotic Resistance in <i>Chlamydia</i> spp" @default.
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- W2171010912 doi "https://doi.org/10.1128/aac.49.7.2865-2873.2005" @default.
- W2171010912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1168699" @default.
- W2171010912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15980362" @default.
- W2171010912 hasPublicationYear "2005" @default.
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