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- W2171013087 abstract "In order to test the effects of various biological treatments on serotonergic function in depression, twenty-one patients with a diagnosis of major depression underwent neuroendocrine challenge tests before and after treatment with either ECT, fluoxetine or amitriptyline. The serotonin (5-HT) releasing agent d-fenfluramine was used as a challenge drug and cortisol (CORT) and prolactin (PRL) plasma levels were monitored over a 5-h period. Overall PRL responses were significantly enhanced following pharmacotherapy irrespective of therapeutic outcome. Effective treatment in each case lowered baseline CORT levels but CORT response to d-fenfluramine remained blunted. Hypercortisolaemia may be involved in the impaired pretreatment PRL response as a strong inverse relationship was established, for the combined studies, between basal CORT plasma concentrations and PRL responses." @default.
- W2171013087 created "2016-06-24" @default.
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- W2171013087 date "1992-11-01" @default.
- W2171013087 modified "2023-09-24" @default.
- W2171013087 title "D-fenfluramine-induced prolactin and cortisol release in major depression: Response to treatment" @default.
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- W2171013087 doi "https://doi.org/10.1016/0165-0327(92)90009-u" @default.
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