Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171023713> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2171023713 endingPage "610" @default.
- W2171023713 startingPage "603" @default.
- W2171023713 abstract "Solitary kidneys, especially in rats, appear vulnerable to develop functional and structural damage. However, differences in susceptibility exist between strains. It is not clear whether this is intrinsic to the kidney or due to environmental factors. Therefore, the aim of the present study was to investigate possible differences in genetic susceptibility for renal damage. By transplanting different rat donor kidneys into a normotensive, histocompatible recipient, the kidneys were exposed to the same blood pressure profiles, metabolic and hormonal environment. Kidneys from young adult hypertensive fawn-hooded (FHH) rats, a strain showing early onset renal damage, normotensive, renal damage-resistant August x Copenhagen-Irish (ACI), and (ACI x FHH) F1 donors were transplanted into male F1 recipients. The native kidneys of the recipients were removed 1 week after transplantation. The results were mutually compared and to their unilaterally nephrectomized littermates. Systolic blood pressure (SBP) and albuminuria (UaV) were determined at the time of transplantation and at 8 and 16 weeks. The histomorphologic analysis included the incidence of focal glomerulosclerosis (FGS), and determination of chronic transplant dysfunction according to the BANFF criteria. A negative impact of the transplantation technique in this syngeneic situation could not be detected as F1 transplants did not differ functionally and morphologically from their UNx controls. Transplanting an ACI kidney did not result in significant changes of SBP, UaV, and incidence of FGS compared to F1 transplants and ACI-UNx. In contrast, FHH kidneys did show a progressive increase of UaV and glomerulosclerosis and a significantly higher BANFF score, whereas the SBP did not differ from F1 transplants. The moderate hypertension seen in FHH did not travel with the kidney. Compared to the FHH-UNx rats, transplantation of a FHH kidney did significantly attenuate the increase of UaV and FGS. The susceptibility of the donor kidney appears to be an important factor in the development of chronic renal damage. This may play a role in the long-term functional changes seen after clinical renal transplantation." @default.
- W2171023713 created "2016-06-24" @default.
- W2171023713 creator A5002145999 @default.
- W2171023713 creator A5028813168 @default.
- W2171023713 creator A5044567914 @default.
- W2171023713 creator A5052145533 @default.
- W2171023713 creator A5066273404 @default.
- W2171023713 creator A5086856138 @default.
- W2171023713 creator A5089682390 @default.
- W2171023713 date "1999-06-01" @default.
- W2171023713 modified "2023-09-28" @default.
- W2171023713 title "Genetic susceptibility of the donor kidney contributes to the development of renal damage after syngeneic transplantation" @default.
- W2171023713 cites W1818334985 @default.
- W2171023713 cites W184643907 @default.
- W2171023713 cites W1965945233 @default.
- W2171023713 cites W1972668462 @default.
- W2171023713 cites W1973880107 @default.
- W2171023713 cites W1976081221 @default.
- W2171023713 cites W1989571869 @default.
- W2171023713 cites W1997938192 @default.
- W2171023713 cites W2003268682 @default.
- W2171023713 cites W2020397175 @default.
- W2171023713 cites W2022745297 @default.
- W2171023713 cites W2053264058 @default.
- W2171023713 cites W2060275268 @default.
- W2171023713 cites W2060518772 @default.
- W2171023713 cites W2097748223 @default.
- W2171023713 cites W2109266820 @default.
- W2171023713 cites W2113850073 @default.
- W2171023713 cites W2121454052 @default.
- W2171023713 cites W2126994039 @default.
- W2171023713 cites W2136667729 @default.
- W2171023713 cites W2157783926 @default.
- W2171023713 cites W2263641643 @default.
- W2171023713 cites W2330293803 @default.
- W2171023713 cites W2338902100 @default.
- W2171023713 cites W2416209860 @default.
- W2171023713 doi "https://doi.org/10.1016/s0895-7061(99)00024-2" @default.
- W2171023713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10371370" @default.
- W2171023713 hasPublicationYear "1999" @default.
- W2171023713 type Work @default.
- W2171023713 sameAs 2171023713 @default.
- W2171023713 citedByCount "5" @default.
- W2171023713 crossrefType "journal-article" @default.
- W2171023713 hasAuthorship W2171023713A5002145999 @default.
- W2171023713 hasAuthorship W2171023713A5028813168 @default.
- W2171023713 hasAuthorship W2171023713A5044567914 @default.
- W2171023713 hasAuthorship W2171023713A5052145533 @default.
- W2171023713 hasAuthorship W2171023713A5066273404 @default.
- W2171023713 hasAuthorship W2171023713A5086856138 @default.
- W2171023713 hasAuthorship W2171023713A5089682390 @default.
- W2171023713 hasBestOaLocation W21710237131 @default.
- W2171023713 hasConcept C126322002 @default.
- W2171023713 hasConcept C126894567 @default.
- W2171023713 hasConcept C134018914 @default.
- W2171023713 hasConcept C2776174234 @default.
- W2171023713 hasConcept C2777390665 @default.
- W2171023713 hasConcept C2778415529 @default.
- W2171023713 hasConcept C2779561371 @default.
- W2171023713 hasConcept C2780091579 @default.
- W2171023713 hasConcept C2780303639 @default.
- W2171023713 hasConcept C2911091166 @default.
- W2171023713 hasConcept C42407357 @default.
- W2171023713 hasConcept C71924100 @default.
- W2171023713 hasConcept C84393581 @default.
- W2171023713 hasConceptScore W2171023713C126322002 @default.
- W2171023713 hasConceptScore W2171023713C126894567 @default.
- W2171023713 hasConceptScore W2171023713C134018914 @default.
- W2171023713 hasConceptScore W2171023713C2776174234 @default.
- W2171023713 hasConceptScore W2171023713C2777390665 @default.
- W2171023713 hasConceptScore W2171023713C2778415529 @default.
- W2171023713 hasConceptScore W2171023713C2779561371 @default.
- W2171023713 hasConceptScore W2171023713C2780091579 @default.
- W2171023713 hasConceptScore W2171023713C2780303639 @default.
- W2171023713 hasConceptScore W2171023713C2911091166 @default.
- W2171023713 hasConceptScore W2171023713C42407357 @default.
- W2171023713 hasConceptScore W2171023713C71924100 @default.
- W2171023713 hasConceptScore W2171023713C84393581 @default.
- W2171023713 hasIssue "6" @default.
- W2171023713 hasLocation W21710237131 @default.
- W2171023713 hasLocation W21710237132 @default.
- W2171023713 hasOpenAccess W2171023713 @default.
- W2171023713 hasPrimaryLocation W21710237131 @default.
- W2171023713 hasRelatedWork W1493683289 @default.
- W2171023713 hasRelatedWork W1525625571 @default.
- W2171023713 hasRelatedWork W2014577469 @default.
- W2171023713 hasRelatedWork W2029580331 @default.
- W2171023713 hasRelatedWork W2156712321 @default.
- W2171023713 hasRelatedWork W2169049520 @default.
- W2171023713 hasRelatedWork W2169633578 @default.
- W2171023713 hasRelatedWork W2171023713 @default.
- W2171023713 hasRelatedWork W2796244375 @default.
- W2171023713 hasRelatedWork W2890909042 @default.
- W2171023713 hasVolume "12" @default.
- W2171023713 isParatext "false" @default.
- W2171023713 isRetracted "false" @default.
- W2171023713 magId "2171023713" @default.
- W2171023713 workType "article" @default.