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- W2171034382 abstract "We attempted to identify and characterize HIV-1 CTL epitopes presented by HLA-B51 which is associated with a slow progression to AIDS. HLA-B∗5101 stabilization assay showed that 33 out of 172 HIV-1 peptides carrying HLA-B∗5101 anchor residues bound to HLA-B∗5101. Seven peptides were suggested as HIV-1 CTL epitopes presented by HLA-B∗5101 because the specific CTL was induced for these peptides in PBMC from three HIV-1 seropositive individuals carrying HLA-B51 by stimulation with HLA-B∗5101 binding peptides. Analysis of these epitopes using the specific CTL clones confirmed that six of seven HIV-1 peptides are epitopes presented by HLA-B∗5101. Three epitopes presented by HLA-B∗5101 are highly conserved among the clade B strain, suggesting that the specific CTL for these epitopes might play an important role in recognition of HIV-1 infected cells. These epitopes will be useful to analyze CTL responses in HIV-1 infected individuals." @default.
- W2171034382 created "2016-06-24" @default.
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- W2171034382 date "1999-03-01" @default.
- W2171034382 modified "2023-10-03" @default.
- W2171034382 title "Identification of multiple HIV-1 CTL epitopes presented by HLA-B∗5101 molecules" @default.
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- W2171034382 doi "https://doi.org/10.1016/s0198-8859(98)00113-x" @default.
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