FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171037485> ?p ?o ?g. }

• W2171037485 endingPage "640" @default.
• W2171037485 startingPage "629" @default.
• W2171037485 abstract "1. Feeding rats on a low-tryptophan, niacin-free, high-leucine diet resulted in impaired synthesis from tryptophan of the nicotinamide nucleotide coenzymes, NAD and NADP, and N1-methyl nicotinamide in isolated hepatocytes, compared with cells from animals fed on a low-tryptophan, niacin-free control diet providing an appropriate amount of leucine. This was accompanied by reduced accumulation of the tryptophan metabolites kynurenine, 3-hydroxykynurenine and xanthurenic acid. 2. With hepatocytes from animals fed on the low-tryptophan, niacin-free control diet, the addition of leucine to the incubation medium resulted in reduced synthesis of niacin from tryptophan, and a small increase in the accumulation of 3-hydroxykynurenine. 3. With hepatocytes from animals fed on the low-tryptophan, niacin-free control diet, the addition of 2-oxoisocaproate to the incubation medium resulted in increased synthesis of NAD(P) and niacin, and increased accumulation of 3-hydroxykynurenine. 4. The results suggest that a dietary excess of leucine alters the activity of the enzymes of tryptophan----niacin metabolism, or the uptake of tryptophan into the liver, in a different manner from the simple inhibition and activation seen in experiments in vitro. 5. Differences between studies in isolated hepatocytes and intact animals suggest that extra-hepatic metabolism of tryptophan, catalysed by indoleamine dioxygenase, is more important than has been believed hitherto." @default.
• W2171037485 created "2016-06-24" @default.
• W2171037485 creator A5081969877 @default.
• W2171037485 date "1989-05-01" @default.
• W2171037485 modified "2023-09-26" @default.
• W2171037485 title "Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells" @default.
• W2171037485 cites W144856505 @default.
• W2171037485 cites W1490154674 @default.
• W2171037485 cites W1578275753 @default.
• W2171037485 cites W167675933 @default.
• W2171037485 cites W1865735651 @default.
• W2171037485 cites W1868144050 @default.
• W2171037485 cites W1922443630 @default.
• W2171037485 cites W1974500405 @default.
• W2171037485 cites W1982530042 @default.
• W2171037485 cites W2016497484 @default.
• W2171037485 cites W2019288474 @default.
• W2171037485 cites W2022307843 @default.
• W2171037485 cites W2029826921 @default.
• W2171037485 cites W2047994342 @default.
• W2171037485 cites W2086336720 @default.
• W2171037485 cites W2089972591 @default.
• W2171037485 cites W2106561035 @default.
• W2171037485 cites W2111922084 @default.
• W2171037485 cites W2114083878 @default.
• W2171037485 cites W2114823502 @default.
• W2171037485 cites W2119046587 @default.
• W2171037485 cites W2163057250 @default.
• W2171037485 cites W2167574473 @default.
• W2171037485 cites W2280024516 @default.
• W2171037485 cites W2282894338 @default.
• W2171037485 cites W2398440160 @default.
• W2171037485 cites W2408774169 @default.
• W2171037485 cites W2416191908 @default.
• W2171037485 cites W268068750 @default.
• W2171037485 cites W305167232 @default.
• W2171037485 cites W54456910 @default.
• W2171037485 doi "https://doi.org/10.1079/bjn19890150" @default.
• W2171037485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2527060" @default.
• W2171037485 hasPublicationYear "1989" @default.
• W2171037485 type Work @default.
• W2171037485 sameAs 2171037485 @default.
• W2171037485 citedByCount "13" @default.
• W2171037485 countsByYear W21710374852012 @default.
• W2171037485 countsByYear W21710374852013 @default.
• W2171037485 countsByYear W21710374852014 @default.
• W2171037485 countsByYear W21710374852015 @default.
• W2171037485 countsByYear W21710374852016 @default.
• W2171037485 countsByYear W21710374852017 @default.
• W2171037485 countsByYear W21710374852020 @default.
• W2171037485 crossrefType "journal-article" @default.
• W2171037485 hasAuthorship W2171037485A5081969877 @default.
• W2171037485 hasBestOaLocation W21710374851 @default.
• W2171037485 hasConcept C126322002 @default.
• W2171037485 hasConcept C134018914 @default.
• W2171037485 hasConcept C181199279 @default.
• W2171037485 hasConcept C25642318 @default.
• W2171037485 hasConcept C2776580952 @default.
• W2171037485 hasConcept C2776706248 @default.
• W2171037485 hasConcept C2777503454 @default.
• W2171037485 hasConcept C2779187253 @default.
• W2171037485 hasConcept C2779439245 @default.
• W2171037485 hasConcept C2779728014 @default.
• W2171037485 hasConcept C2780092750 @default.
• W2171037485 hasConcept C515207424 @default.
• W2171037485 hasConcept C55493867 @default.
• W2171037485 hasConcept C62231903 @default.
• W2171037485 hasConcept C71924100 @default.
• W2171037485 hasConcept C75520062 @default.
• W2171037485 hasConcept C86803240 @default.
• W2171037485 hasConceptScore W2171037485C126322002 @default.
• W2171037485 hasConceptScore W2171037485C134018914 @default.
• W2171037485 hasConceptScore W2171037485C181199279 @default.
• W2171037485 hasConceptScore W2171037485C25642318 @default.
• W2171037485 hasConceptScore W2171037485C2776580952 @default.
• W2171037485 hasConceptScore W2171037485C2776706248 @default.
• W2171037485 hasConceptScore W2171037485C2777503454 @default.
• W2171037485 hasConceptScore W2171037485C2779187253 @default.
• W2171037485 hasConceptScore W2171037485C2779439245 @default.
• W2171037485 hasConceptScore W2171037485C2779728014 @default.
• W2171037485 hasConceptScore W2171037485C2780092750 @default.
• W2171037485 hasConceptScore W2171037485C515207424 @default.
• W2171037485 hasConceptScore W2171037485C55493867 @default.
• W2171037485 hasConceptScore W2171037485C62231903 @default.
• W2171037485 hasConceptScore W2171037485C71924100 @default.
• W2171037485 hasConceptScore W2171037485C75520062 @default.
• W2171037485 hasConceptScore W2171037485C86803240 @default.
• W2171037485 hasIssue "3" @default.
• W2171037485 hasLocation W21710374851 @default.
• W2171037485 hasLocation W21710374852 @default.
• W2171037485 hasOpenAccess W2171037485 @default.
• W2171037485 hasPrimaryLocation W21710374851 @default.
• W2171037485 hasRelatedWork W1843806239 @default.
• W2171037485 hasRelatedWork W1896156599 @default.
• W2171037485 hasRelatedWork W2016497484 @default.
• W2171037485 hasRelatedWork W2019224474 @default.
• W2171037485 hasRelatedWork W2055000363 @default.
• W2171037485 hasRelatedWork W2140987806 @default.

• next