FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171040147> ?p ?o ?g. }

• W2171040147 endingPage "229" @default.
• W2171040147 startingPage "220" @default.
• W2171040147 abstract "Rationale: Endothelial cells are developmentally derived from angioblasts specified in the mesodermal germ cell layer. The transcription factor etsrp/etv2 is at the top of the known genetic hierarchy for angioblast development. The transcriptional events that induce etsrp expression and angioblast specification are not well understood. Objective: We generated etsrp:gfp transgenic zebrafish and used them to identify regulatory regions and transcription factors critical for etsrp expression and angioblast specification from mesoderm. Methods and Results: To investigate the mechanisms that initiate angioblast cell transcription during embryogenesis, we have performed promoter analysis of the etsrp locus in zebrafish. We describe three enhancer elements sufficient for endothelial gene expression when place in front of a heterologous promoter. The deletion of all 3 regulatory regions led to a near complete loss of endothelial expression from the etsrp promoter. One of the enhancers, located 2.3 kb upstream of etsrp contains a consensus FOX binding site that binds Foxc1a and Foxc1b in vitro by EMSA and in vivo using ChIP. Combined knockdown of foxc1a/b , using morpholinos, led to a significant decrease in etsrp expression at early developmental stages as measured by quantitative reverse transcriptase–polymerase chain reaction and in situ hybridization. Decreased expression of primitive erythrocyte genes scl and gata1 was also observed, whereas pronephric gene pax2a was relatively normal in expression level and pattern. Conclusions: These findings identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast." @default.
• W2171040147 created "2016-06-24" @default.
• W2171040147 creator A5014287900 @default.
• W2171040147 creator A5087496453 @default.
• W2171040147 date "2012-01-20" @default.
• W2171040147 modified "2023-10-16" @default.
• W2171040147 title "Etsrp/Etv2 Is Directly Regulated by <i>Foxc1a/b</i> in the Zebrafish Angioblast" @default.
• W2171040147 cites W1529788780 @default.
• W2171040147 cites W1632348764 @default.
• W2171040147 cites W1963545188 @default.
• W2171040147 cites W1964918240 @default.
• W2171040147 cites W1967801942 @default.
• W2171040147 cites W1975495921 @default.
• W2171040147 cites W1976212341 @default.
• W2171040147 cites W197715220 @default.
• W2171040147 cites W1981064211 @default.
• W2171040147 cites W1981101983 @default.
• W2171040147 cites W1984338606 @default.
• W2171040147 cites W1984442770 @default.
• W2171040147 cites W1992511977 @default.
• W2171040147 cites W2001784727 @default.
• W2171040147 cites W2004537703 @default.
• W2171040147 cites W2007827699 @default.
• W2171040147 cites W2011237068 @default.
• W2171040147 cites W2017650279 @default.
• W2171040147 cites W2031632681 @default.
• W2171040147 cites W2038539380 @default.
• W2171040147 cites W2041034019 @default.
• W2171040147 cites W2046319228 @default.
• W2171040147 cites W2065115929 @default.
• W2171040147 cites W2070074926 @default.
• W2171040147 cites W2070298717 @default.
• W2171040147 cites W2076600697 @default.
• W2171040147 cites W2082664445 @default.
• W2171040147 cites W2087270708 @default.
• W2171040147 cites W2091433662 @default.
• W2171040147 cites W2091760375 @default.
• W2171040147 cites W2106201608 @default.
• W2171040147 cites W2109418446 @default.
• W2171040147 cites W2109998234 @default.
• W2171040147 cites W2111122566 @default.
• W2171040147 cites W2126393744 @default.
• W2171040147 cites W2135030836 @default.
• W2171040147 cites W2147136456 @default.
• W2171040147 cites W2147454032 @default.
• W2171040147 cites W2161533644 @default.
• W2171040147 cites W2161922597 @default.
• W2171040147 cites W2168027290 @default.
• W2171040147 doi "https://doi.org/10.1161/circresaha.111.251298" @default.
• W2171040147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3457812" @default.
• W2171040147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22135404" @default.
• W2171040147 hasPublicationYear "2012" @default.
• W2171040147 type Work @default.
• W2171040147 sameAs 2171040147 @default.
• W2171040147 citedByCount "56" @default.
• W2171040147 countsByYear W21710401472012 @default.
• W2171040147 countsByYear W21710401472013 @default.
• W2171040147 countsByYear W21710401472014 @default.
• W2171040147 countsByYear W21710401472015 @default.
• W2171040147 countsByYear W21710401472016 @default.
• W2171040147 countsByYear W21710401472017 @default.
• W2171040147 countsByYear W21710401472018 @default.
• W2171040147 countsByYear W21710401472019 @default.
• W2171040147 countsByYear W21710401472020 @default.
• W2171040147 countsByYear W21710401472021 @default.
• W2171040147 countsByYear W21710401472022 @default.
• W2171040147 countsByYear W21710401472023 @default.
• W2171040147 crossrefType "journal-article" @default.
• W2171040147 hasAuthorship W2171040147A5014287900 @default.
• W2171040147 hasAuthorship W2171040147A5087496453 @default.
• W2171040147 hasBestOaLocation W21710401471 @default.
• W2171040147 hasConcept C101762097 @default.
• W2171040147 hasConcept C104317684 @default.
• W2171040147 hasConcept C111936080 @default.
• W2171040147 hasConcept C136571751 @default.
• W2171040147 hasConcept C138885662 @default.
• W2171040147 hasConcept C145103041 @default.
• W2171040147 hasConcept C150194340 @default.
• W2171040147 hasConcept C153911025 @default.
• W2171040147 hasConcept C162407555 @default.
• W2171040147 hasConcept C173396325 @default.
• W2171040147 hasConcept C179926584 @default.
• W2171040147 hasConcept C2776878037 @default.
• W2171040147 hasConcept C2780915607 @default.
• W2171040147 hasConcept C41895202 @default.
• W2171040147 hasConcept C54355233 @default.
• W2171040147 hasConcept C86339819 @default.
• W2171040147 hasConcept C86803240 @default.
• W2171040147 hasConcept C95444343 @default.
• W2171040147 hasConceptScore W2171040147C101762097 @default.
• W2171040147 hasConceptScore W2171040147C104317684 @default.
• W2171040147 hasConceptScore W2171040147C111936080 @default.
• W2171040147 hasConceptScore W2171040147C136571751 @default.
• W2171040147 hasConceptScore W2171040147C138885662 @default.
• W2171040147 hasConceptScore W2171040147C145103041 @default.
• W2171040147 hasConceptScore W2171040147C150194340 @default.
• W2171040147 hasConceptScore W2171040147C153911025 @default.
• W2171040147 hasConceptScore W2171040147C162407555 @default.

• next