Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171081446> ?p ?o ?g. }
- W2171081446 endingPage "586" @default.
- W2171081446 startingPage "573" @default.
- W2171081446 abstract "Abstract The regulation of telomere length equilibrium is essential for cell growth and survival since critically short telomeres signal DNA damage and cell cycle arrest. While the broad principles of length regulation are well established, the molecular mechanism of how these steps occur is not fully understood. We mutagenized the RIF2 gene in Saccharomyces cerevisiae to understand how this protein blocks excess telomere elongation. We identified an N-terminal domain in Rif2 that is essential for length regulation, which we have termed BAT domain for Blocks Addition of Telomeres. Tethering this BAT domain to Rap1 blocked telomere elongation not only in rif2Δ mutants but also in rif1Δ and rap1C-terminal deletion mutants. Mutation of a single amino acid in the BAT domain, phenylalanine at position 8 to alanine, recapitulated the rif2Δ mutant phenotype. Substitution of F8 with tryptophan mimicked the wild-type phenylalanine, suggesting the aromatic amino acid represents a protein interaction site that is essential for telomere length regulation." @default.
- W2171081446 created "2016-06-24" @default.
- W2171081446 creator A5026943233 @default.
- W2171081446 creator A5041730448 @default.
- W2171081446 creator A5044563196 @default.
- W2171081446 creator A5057281461 @default.
- W2171081446 creator A5062518300 @default.
- W2171081446 date "2015-08-20" @default.
- W2171081446 modified "2023-10-01" @default.
- W2171081446 title "Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in <i>Saccharomyces cerevisiae</i>" @default.
- W2171081446 cites W1488701566 @default.
- W2171081446 cites W1791797059 @default.
- W2171081446 cites W1895938869 @default.
- W2171081446 cites W1942306459 @default.
- W2171081446 cites W1964612763 @default.
- W2171081446 cites W1966072209 @default.
- W2171081446 cites W1970891016 @default.
- W2171081446 cites W1973544851 @default.
- W2171081446 cites W1975548607 @default.
- W2171081446 cites W1978002329 @default.
- W2171081446 cites W1979164620 @default.
- W2171081446 cites W1981775109 @default.
- W2171081446 cites W1983228670 @default.
- W2171081446 cites W1983673827 @default.
- W2171081446 cites W1988669405 @default.
- W2171081446 cites W1991736695 @default.
- W2171081446 cites W2000971601 @default.
- W2171081446 cites W2003785817 @default.
- W2171081446 cites W2011153669 @default.
- W2171081446 cites W2021238352 @default.
- W2171081446 cites W2021407910 @default.
- W2171081446 cites W2030209169 @default.
- W2171081446 cites W2037061918 @default.
- W2171081446 cites W2043745412 @default.
- W2171081446 cites W2046909262 @default.
- W2171081446 cites W2051412762 @default.
- W2171081446 cites W2057092384 @default.
- W2171081446 cites W2065858253 @default.
- W2171081446 cites W2069367380 @default.
- W2171081446 cites W2070887305 @default.
- W2171081446 cites W2083168268 @default.
- W2171081446 cites W2086992094 @default.
- W2171081446 cites W2096391864 @default.
- W2171081446 cites W2099540110 @default.
- W2171081446 cites W2104500293 @default.
- W2171081446 cites W2105265620 @default.
- W2171081446 cites W2108482850 @default.
- W2171081446 cites W2109089733 @default.
- W2171081446 cites W2111723163 @default.
- W2171081446 cites W2112033616 @default.
- W2171081446 cites W2113168077 @default.
- W2171081446 cites W2116463355 @default.
- W2171081446 cites W2116680984 @default.
- W2171081446 cites W2122740168 @default.
- W2171081446 cites W2124145893 @default.
- W2171081446 cites W2128940137 @default.
- W2171081446 cites W2133885656 @default.
- W2171081446 cites W2134283983 @default.
- W2171081446 cites W2135612520 @default.
- W2171081446 cites W2141185701 @default.
- W2171081446 cites W2146204567 @default.
- W2171081446 cites W2146503498 @default.
- W2171081446 cites W2150490516 @default.
- W2171081446 cites W2152805035 @default.
- W2171081446 cites W2153408508 @default.
- W2171081446 cites W2154484165 @default.
- W2171081446 cites W2156911227 @default.
- W2171081446 cites W2159094470 @default.
- W2171081446 cites W2159372765 @default.
- W2171081446 cites W2160618567 @default.
- W2171081446 cites W2162261435 @default.
- W2171081446 cites W2163649668 @default.
- W2171081446 cites W2169333620 @default.
- W2171081446 doi "https://doi.org/10.1534/genetics.115.177899" @default.
- W2171081446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596670" @default.
- W2171081446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26294668" @default.
- W2171081446 hasPublicationYear "2015" @default.
- W2171081446 type Work @default.
- W2171081446 sameAs 2171081446 @default.
- W2171081446 citedByCount "20" @default.
- W2171081446 countsByYear W21710814462017 @default.
- W2171081446 countsByYear W21710814462018 @default.
- W2171081446 countsByYear W21710814462019 @default.
- W2171081446 countsByYear W21710814462021 @default.
- W2171081446 countsByYear W21710814462022 @default.
- W2171081446 countsByYear W21710814462023 @default.
- W2171081446 crossrefType "journal-article" @default.
- W2171081446 hasAuthorship W2171081446A5026943233 @default.
- W2171081446 hasAuthorship W2171081446A5041730448 @default.
- W2171081446 hasAuthorship W2171081446A5044563196 @default.
- W2171081446 hasAuthorship W2171081446A5057281461 @default.
- W2171081446 hasAuthorship W2171081446A5062518300 @default.
- W2171081446 hasBestOaLocation W21710814461 @default.
- W2171081446 hasConcept C104317684 @default.
- W2171081446 hasConcept C143065580 @default.
- W2171081446 hasConcept C177336024 @default.
- W2171081446 hasConcept C202265312 @default.
- W2171081446 hasConcept C2777576037 @default.