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• W2171114919 abstract "The purpose of this work was to study tolmetin plasma protein binding in an experimental model of hypoalbuminemia in the rat. Hypoalbuminemia was produced by repetitive plasmapheresis, achieving a 26.2 +/- 4.6% reduction in albumin circulating levels. Rats then received a 100 mg/kg oral tolmetin dose. Control rats received oral tolmetin 10, 56 or 100 mg/kg. Tolmetin plasma protein binding was determined by an ultrafiltration technique using an in vivo pharmacokinetic approach. Plasma protein binding data for the 3 doses studies in control animals could be described considering a single binding site with Kd = 21.9 +/- 2.1 microM and N = 0.98 +/- 0.05 sites per molecule of albumin. For hypoalbuminemic rats Kd was significantly increased (p < 0.05), while there was no significant change in the number of binding site per albumin molecule (Kd = 131.6 +/- 38.1 microM and N = 1.58 +/- 0.77). Our results show that hypoalbuminemia produces a disproportionate increase in the free fraction of tolmetin, not only by reducing albumin concentration, but also by a decrease in affinity. The mechanism responsible of such changes in affinity remains to be elucidated." @default.
• W2171114919 created "2016-06-24" @default.
• W2171114919 creator A5041079453 @default.
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• W2171114919 date "2002-07-01" @default.
• W2171114919 modified "2023-10-12" @default.
• W2171114919 title "Effect of experimental hypoalbuminemia on the plasma protein binding of tolmetin" @default.
• W2171114919 cites W1508094786 @default.
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• W2171114919 doi "https://doi.org/10.1016/s0024-3205(02)01788-5" @default.
• W2171114919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12088761" @default.
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