FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171118412> ?p ?o ?g. }

• W2171118412 endingPage "1196" @default.
• W2171118412 startingPage "1190" @default.
• W2171118412 abstract "We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a self-assembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pH-responsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core–shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer." @default.
• W2171118412 created "2016-06-24" @default.
• W2171118412 creator A5029992386 @default.
• W2171118412 creator A5030461290 @default.
• W2171118412 creator A5034945169 @default.
• W2171118412 creator A5044299331 @default.
• W2171118412 creator A5073081708 @default.
• W2171118412 creator A5082407014 @default.
• W2171118412 creator A5091529914 @default.
• W2171118412 date "2012-03-27" @default.
• W2171118412 modified "2023-09-27" @default.
• W2171118412 title "Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery" @default.
• W2171118412 cites W1973017820 @default.
• W2171118412 cites W1980178107 @default.
• W2171118412 cites W1981453679 @default.
• W2171118412 cites W1982089656 @default.
• W2171118412 cites W1985420695 @default.
• W2171118412 cites W1986710257 @default.
• W2171118412 cites W1988864059 @default.
• W2171118412 cites W2000947203 @default.
• W2171118412 cites W2001825884 @default.
• W2171118412 cites W2008515510 @default.
• W2171118412 cites W2032760352 @default.
• W2171118412 cites W2032993907 @default.
• W2171118412 cites W2033294149 @default.
• W2171118412 cites W2044607163 @default.
• W2171118412 cites W2052979358 @default.
• W2171118412 cites W2054045589 @default.
• W2171118412 cites W2059212524 @default.
• W2171118412 cites W2061139525 @default.
• W2171118412 cites W2061719532 @default.
• W2171118412 cites W2082587127 @default.
• W2171118412 cites W2089369270 @default.
• W2171118412 cites W2090201623 @default.
• W2171118412 cites W2091982741 @default.
• W2171118412 cites W2094236555 @default.
• W2171118412 cites W2114918609 @default.
• W2171118412 cites W2118307660 @default.
• W2171118412 cites W2120915183 @default.
• W2171118412 cites W2139680554 @default.
• W2171118412 cites W2142743818 @default.
• W2171118412 cites W2316671269 @default.
• W2171118412 cites W2327242595 @default.
• W2171118412 cites W4246926463 @default.
• W2171118412 doi "https://doi.org/10.1021/bm300151m" @default.
• W2171118412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22414172" @default.
• W2171118412 hasPublicationYear "2012" @default.
• W2171118412 type Work @default.
• W2171118412 sameAs 2171118412 @default.
• W2171118412 citedByCount "126" @default.
• W2171118412 countsByYear W21711184122013 @default.
• W2171118412 countsByYear W21711184122014 @default.
• W2171118412 countsByYear W21711184122015 @default.
• W2171118412 countsByYear W21711184122016 @default.
• W2171118412 countsByYear W21711184122017 @default.
• W2171118412 countsByYear W21711184122018 @default.
• W2171118412 countsByYear W21711184122019 @default.
• W2171118412 countsByYear W21711184122020 @default.
• W2171118412 countsByYear W21711184122021 @default.
• W2171118412 countsByYear W21711184122022 @default.
• W2171118412 countsByYear W21711184122023 @default.
• W2171118412 crossrefType "journal-article" @default.
• W2171118412 hasAuthorship W2171118412A5029992386 @default.
• W2171118412 hasAuthorship W2171118412A5030461290 @default.
• W2171118412 hasAuthorship W2171118412A5034945169 @default.
• W2171118412 hasAuthorship W2171118412A5044299331 @default.
• W2171118412 hasAuthorship W2171118412A5073081708 @default.
• W2171118412 hasAuthorship W2171118412A5082407014 @default.
• W2171118412 hasAuthorship W2171118412A5091529914 @default.
• W2171118412 hasConcept C11268172 @default.
• W2171118412 hasConcept C127413603 @default.
• W2171118412 hasConcept C14631669 @default.
• W2171118412 hasConcept C155574463 @default.
• W2171118412 hasConcept C155672457 @default.
• W2171118412 hasConcept C15920480 @default.
• W2171118412 hasConcept C163588942 @default.
• W2171118412 hasConcept C171250308 @default.
• W2171118412 hasConcept C178790620 @default.
• W2171118412 hasConcept C184651966 @default.
• W2171118412 hasConcept C185592680 @default.
• W2171118412 hasConcept C188027245 @default.
• W2171118412 hasConcept C192562407 @default.
• W2171118412 hasConcept C21951064 @default.
• W2171118412 hasConcept C2777230088 @default.
• W2171118412 hasConcept C2777516009 @default.
• W2171118412 hasConcept C2777801237 @default.
• W2171118412 hasConcept C2779820397 @default.
• W2171118412 hasConcept C42360764 @default.
• W2171118412 hasConcept C521977710 @default.
• W2171118412 hasConceptScore W2171118412C11268172 @default.
• W2171118412 hasConceptScore W2171118412C127413603 @default.
• W2171118412 hasConceptScore W2171118412C14631669 @default.
• W2171118412 hasConceptScore W2171118412C155574463 @default.
• W2171118412 hasConceptScore W2171118412C155672457 @default.
• W2171118412 hasConceptScore W2171118412C15920480 @default.
• W2171118412 hasConceptScore W2171118412C163588942 @default.
• W2171118412 hasConceptScore W2171118412C171250308 @default.
• W2171118412 hasConceptScore W2171118412C178790620 @default.

• next