FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171132931> ?p ?o ?g. }

• W2171132931 endingPage "284" @default.
• W2171132931 startingPage "271" @default.
• W2171132931 abstract "The hippocampal formation, which contains high levels of adrenal steroid receptors, is vulnerable to insults such as stroke, seizures, and head trauma, and it is also sensitive and vulnerable to the effects of stress. We have discovered that the hippocampus of rodents and tree shrews shows atrophy of pyramidal neurons in the CA3 region. Psychosocial stress and restraint stress produce atrophy over approximately 3-4 weeks. Atrophy is blocked by inhibiting adrenal steroid formation and by blocking the actions of excitatory amino acids using Dilantin or NMDA receptor inhibitors. Glucocorticoid administration also blocks CA3 atrophy, but Dilantin administration blocks this as well, indicating that excitatory amino acid release mediates the atrophy, which likely involves disassembly of the dendritic cytoskeleton. Studies with in vivo microdialysis in several laboratories have shown that glutamate release in the hippocampus increases in stress and that stress-induced glutamate release is reduced by adrenalectomy. Recent electron microscopy of mossy fiber terminals on CA3 neurons has revealed a depletion of synaptic vesicles as a result of repeated stress. The mossy fiber terminals appear to be responsible for driving atrophy of CA3 neurons, which involves principally atrophy of the apical dendrites. These results are discussed in relation to data from MRI showing atrophy of the whole human hippocampus in Cushing's disease, recurrent depressive illness, PTSD, and normal aging as well as dementia." @default.
• W2171132931 created "2016-06-24" @default.
• W2171132931 creator A5021349263 @default.
• W2171132931 creator A5035103174 @default.
• W2171132931 date "1997-06-01" @default.
• W2171132931 modified "2023-09-26" @default.
• W2171132931 title "Stress Effects on Morphology and Function of the Hippocampus" @default.
• W2171132931 cites W1027857307 @default.
• W2171132931 cites W1489028475 @default.
• W2171132931 cites W170792860 @default.
• W2171132931 cites W1804267428 @default.
• W2171132931 cites W1914011667 @default.
• W2171132931 cites W1920785023 @default.
• W2171132931 cites W1930989519 @default.
• W2171132931 cites W1969934591 @default.
• W2171132931 cites W1970377013 @default.
• W2171132931 cites W1976551861 @default.
• W2171132931 cites W1977249405 @default.
• W2171132931 cites W1978090657 @default.
• W2171132931 cites W1979406476 @default.
• W2171132931 cites W1981724466 @default.
• W2171132931 cites W1986225347 @default.
• W2171132931 cites W1992026104 @default.
• W2171132931 cites W2007372337 @default.
• W2171132931 cites W2013400604 @default.
• W2171132931 cites W2014212152 @default.
• W2171132931 cites W2015052061 @default.
• W2171132931 cites W2019316537 @default.
• W2171132931 cites W2027066838 @default.
• W2171132931 cites W2036049398 @default.
• W2171132931 cites W2038852586 @default.
• W2171132931 cites W2049031957 @default.
• W2171132931 cites W2049250772 @default.
• W2171132931 cites W2051157780 @default.
• W2171132931 cites W2051715358 @default.
• W2171132931 cites W2052464658 @default.
• W2171132931 cites W2055065216 @default.
• W2171132931 cites W2056136848 @default.
• W2171132931 cites W2060589548 @default.
• W2171132931 cites W2060644077 @default.
• W2171132931 cites W2078090509 @default.
• W2171132931 cites W2079017678 @default.
• W2171132931 cites W2080118525 @default.
• W2171132931 cites W2084997223 @default.
• W2171132931 cites W2085380618 @default.
• W2171132931 cites W2088013883 @default.
• W2171132931 cites W2088301054 @default.
• W2171132931 cites W2089579499 @default.
• W2171132931 cites W2092247159 @default.
• W2171132931 cites W2093034762 @default.
• W2171132931 cites W2108819818 @default.
• W2171132931 cites W2119257185 @default.
• W2171132931 cites W2123637685 @default.
• W2171132931 cites W2134033459 @default.
• W2171132931 cites W2141195478 @default.
• W2171132931 cites W2151340091 @default.
• W2171132931 cites W2159699558 @default.
• W2171132931 cites W2160282214 @default.
• W2171132931 cites W2164626680 @default.
• W2171132931 cites W2171180721 @default.
• W2171132931 cites W4246123636 @default.
• W2171132931 cites W4250989989 @default.
• W2171132931 doi "https://doi.org/10.1111/j.1749-6632.1997.tb48286.x" @default.
• W2171132931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9238211" @default.
• W2171132931 hasPublicationYear "1997" @default.
• W2171132931 type Work @default.
• W2171132931 sameAs 2171132931 @default.
• W2171132931 citedByCount "372" @default.
• W2171132931 countsByYear W21711329312012 @default.
• W2171132931 countsByYear W21711329312013 @default.
• W2171132931 countsByYear W21711329312014 @default.
• W2171132931 countsByYear W21711329312015 @default.
• W2171132931 countsByYear W21711329312016 @default.
• W2171132931 countsByYear W21711329312017 @default.
• W2171132931 countsByYear W21711329312018 @default.
• W2171132931 countsByYear W21711329312019 @default.
• W2171132931 countsByYear W21711329312020 @default.
• W2171132931 countsByYear W21711329312021 @default.
• W2171132931 countsByYear W21711329312022 @default.
• W2171132931 countsByYear W21711329312023 @default.
• W2171132931 crossrefType "journal-article" @default.
• W2171132931 hasAuthorship W2171132931A5021349263 @default.
• W2171132931 hasAuthorship W2171132931A5035103174 @default.
• W2171132931 hasConcept C112592302 @default.
• W2171132931 hasConcept C126322002 @default.
• W2171132931 hasConcept C134018914 @default.
• W2171132931 hasConcept C148762608 @default.
• W2171132931 hasConcept C169760540 @default.
• W2171132931 hasConcept C170493617 @default.
• W2171132931 hasConcept C17077164 @default.
• W2171132931 hasConcept C185592680 @default.
• W2171132931 hasConcept C2776464000 @default.
• W2171132931 hasConcept C2777318268 @default.
• W2171132931 hasConcept C2781161787 @default.
• W2171132931 hasConcept C2781172350 @default.
• W2171132931 hasConcept C61174792 @default.
• W2171132931 hasConcept C67018056 @default.
• W2171132931 hasConcept C71924100 @default.

• next