Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171133607> ?p ?o ?g. }
- W2171133607 endingPage "302" @default.
- W2171133607 startingPage "289" @default.
- W2171133607 abstract "We studied the cellular and subcellular localization of G α-subunits in pancreas by immunocytochemistry. Golfα and G11α were specifically localized in islet insulin B-cells and glucagon A-cells, respectively. Gs α and Gqα labeling was more abundant in B-cells. The presence of Golfα in B-cells was confirmed by in situ hybridization. In B-cells, Golfα and Gsα were found in the Golgi apparatus, plasma membrane (PM) and, remarkably, in mature and immature insulin secretory granules, mainly at the periphery of the insulin grains. Gqα was detected on the rough endoplasmic reticulum (RER) near the Golgi apparatus. In A-cells, the Gα-subunits were mostly within the glucagon granules: G11 α gave the strongest signal, Gsα less strong, Gq was scarce, and Golf was practically absent. Gqα and Gsα immunoreactivity was detected in acinar cells, although it was much weaker than that in islet cells. The cell-dependent distribution of the Gα-subunits indicates that the stimulatory pathways for pancreatic function differ in acinar and in islet B- and A-cells. Furthermore, the G-protein subunits in islet cell secretory granules might be functional and participate in granule trafficking and hormone secretion." @default.
- W2171133607 created "2016-06-24" @default.
- W2171133607 creator A5034429155 @default.
- W2171133607 creator A5037325444 @default.
- W2171133607 creator A5048342497 @default.
- W2171133607 creator A5051242393 @default.
- W2171133607 creator A5070703961 @default.
- W2171133607 creator A5077335958 @default.
- W2171133607 creator A5085781030 @default.
- W2171133607 date "1999-03-01" @default.
- W2171133607 modified "2023-10-03" @default.
- W2171133607 title "Cellular and Subcellular Expression of Golf/Gs and Gq/G11 α-Subunits in Rat Pancreatic Endocrine Cells" @default.
- W2171133607 cites W1537485370 @default.
- W2171133607 cites W1547329911 @default.
- W2171133607 cites W1556103840 @default.
- W2171133607 cites W1575960707 @default.
- W2171133607 cites W1925400913 @default.
- W2171133607 cites W1966463198 @default.
- W2171133607 cites W1973523320 @default.
- W2171133607 cites W1974929450 @default.
- W2171133607 cites W1975866482 @default.
- W2171133607 cites W1981358109 @default.
- W2171133607 cites W1981660336 @default.
- W2171133607 cites W1984212762 @default.
- W2171133607 cites W1989092000 @default.
- W2171133607 cites W1992206745 @default.
- W2171133607 cites W1994364787 @default.
- W2171133607 cites W1998308514 @default.
- W2171133607 cites W2007650753 @default.
- W2171133607 cites W2013978625 @default.
- W2171133607 cites W2015001023 @default.
- W2171133607 cites W2016073900 @default.
- W2171133607 cites W2018239076 @default.
- W2171133607 cites W2022973051 @default.
- W2171133607 cites W2023688837 @default.
- W2171133607 cites W2024901571 @default.
- W2171133607 cites W2029430014 @default.
- W2171133607 cites W2030315443 @default.
- W2171133607 cites W2034732034 @default.
- W2171133607 cites W2034984305 @default.
- W2171133607 cites W2035676720 @default.
- W2171133607 cites W2038862314 @default.
- W2171133607 cites W2045454429 @default.
- W2171133607 cites W2055006835 @default.
- W2171133607 cites W2055435941 @default.
- W2171133607 cites W2063562555 @default.
- W2171133607 cites W2070288681 @default.
- W2171133607 cites W2075316492 @default.
- W2171133607 cites W2087179850 @default.
- W2171133607 cites W2100837269 @default.
- W2171133607 cites W2103600331 @default.
- W2171133607 cites W2116739144 @default.
- W2171133607 cites W2133596751 @default.
- W2171133607 cites W2143809887 @default.
- W2171133607 cites W2149434797 @default.
- W2171133607 cites W2170426482 @default.
- W2171133607 cites W2345608159 @default.
- W2171133607 cites W4293247451 @default.
- W2171133607 doi "https://doi.org/10.1177/002215549904700303" @default.
- W2171133607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10026232" @default.
- W2171133607 hasPublicationYear "1999" @default.
- W2171133607 type Work @default.
- W2171133607 sameAs 2171133607 @default.
- W2171133607 citedByCount "15" @default.
- W2171133607 countsByYear W21711336072012 @default.
- W2171133607 countsByYear W21711336072022 @default.
- W2171133607 crossrefType "journal-article" @default.
- W2171133607 hasAuthorship W2171133607A5034429155 @default.
- W2171133607 hasAuthorship W2171133607A5037325444 @default.
- W2171133607 hasAuthorship W2171133607A5048342497 @default.
- W2171133607 hasAuthorship W2171133607A5051242393 @default.
- W2171133607 hasAuthorship W2171133607A5070703961 @default.
- W2171133607 hasAuthorship W2171133607A5077335958 @default.
- W2171133607 hasAuthorship W2171133607A5085781030 @default.
- W2171133607 hasBestOaLocation W21711336071 @default.
- W2171133607 hasConcept C103395026 @default.
- W2171133607 hasConcept C119062480 @default.
- W2171133607 hasConcept C126322002 @default.
- W2171133607 hasConcept C134018914 @default.
- W2171133607 hasConcept C158617107 @default.
- W2171133607 hasConcept C165220095 @default.
- W2171133607 hasConcept C185592680 @default.
- W2171133607 hasConcept C190062978 @default.
- W2171133607 hasConcept C2776879804 @default.
- W2171133607 hasConcept C2778563252 @default.
- W2171133607 hasConcept C2778764654 @default.
- W2171133607 hasConcept C2779306644 @default.
- W2171133607 hasConcept C35866371 @default.
- W2171133607 hasConcept C46699223 @default.
- W2171133607 hasConcept C49039625 @default.
- W2171133607 hasConcept C6492254 @default.
- W2171133607 hasConcept C71315377 @default.
- W2171133607 hasConcept C71924100 @default.
- W2171133607 hasConcept C86803240 @default.
- W2171133607 hasConcept C95444343 @default.
- W2171133607 hasConceptScore W2171133607C103395026 @default.
- W2171133607 hasConceptScore W2171133607C119062480 @default.
- W2171133607 hasConceptScore W2171133607C126322002 @default.