FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171149082> ?p ?o ?g. }

• W2171149082 endingPage "1233" @default.
• W2171149082 startingPage "1230" @default.
• W2171149082 abstract "Recurrent loss of heterozygosity (LOH) in 4q24 in patients with myeloid malignancies has led to the identifi cation of mutations in TET2 in diff erent myeloid neoplasms including myeloproliferative neoplasm (MPN), myelodysplastic syndrome (MDS), mixed myelodysplastic/myeloproliferative neoplasm (MDS/MPN) and acute myeloid leukemia (AML) [1 – 13]. Th eir impact on prognosis remains unresolved, and the mechanisms by which TET2 leads to transformation remain unclear. Based on its homology to TET1, it is possible that TET2 may play a role in epigenetic regulation [14] via the presence of catalytic domains in the two highly conserved regions of the gene. Mutations in these two regions could, by this mechanism, lead to inactivation of a specifi c tumor suppressor gene and/or activation of pro-proliferative pathways, although mutations in other areas of the gene could also result in a modifi cation of the protein. Studies using murine models of Tet2 inactivation show that inactivation of this gene establishes important roles for Tet2 in hematopoiesis and the development of myeloproliferative disease. Beacuse TET2 alterations in patients are commonly heterozygous, TET2 haploinsuffi ciency could be enough to promote defects in a hematopoietic progenitor and myeloproliferation [15]. We have collected data on all TET2 mutations published to date [1 – 13] (a total of 725 mutations in 3274 patients) (Table I) in order to analyze whether: (a) they are evenly distributed throughout the gene, (b) diff erent mutation types (missense, nonsense or frameshift) are more prevalent in diff erent regions of the gene and (c) distinct mutational patterns are found in diff erent types of myeloid neoplasms. To this end, we divided the sequence of the TET2 gene into four regions. Region B1 ( Box 1 ) and region B2 ( Box 2 ) are highly conserved in several species and in all three proteins of the TET family. Th e other two regions, which we denominated F1 and F2, are non-conserved regions (Figure 1). We calculated the frequency of mutations per amino acid in each of these regions (number of mutations divided by the number of amino acids" @default.
• W2171149082 created "2016-06-24" @default.
• W2171149082 creator A5019728385 @default.
• W2171149082 creator A5035426858 @default.
• W2171149082 creator A5043417417 @default.
• W2171149082 creator A5050104014 @default.
• W2171149082 creator A5052937049 @default.
• W2171149082 creator A5057847328 @default.
• W2171149082 creator A5070483364 @default.
• W2171149082 creator A5072456422 @default.
• W2171149082 date "2012-04-02" @default.
• W2171149082 modified "2023-10-08" @default.
• W2171149082 title "A meta-analysis of <i>TET2</i> mutations shows a distinct distribution pattern in <i>de novo</i> acute myeloid leukemia and chronic myelomonocytic leukemia" @default.
• W2171149082 cites W1994467709 @default.
• W2171149082 cites W2002006718 @default.
• W2171149082 cites W2005458309 @default.
• W2171149082 cites W2012080286 @default.
• W2171149082 cites W2028803880 @default.
• W2171149082 cites W2057867563 @default.
• W2171149082 cites W2067797084 @default.
• W2171149082 cites W2093754271 @default.
• W2171149082 cites W2096102839 @default.
• W2171149082 cites W2108664872 @default.
• W2171149082 cites W2109150359 @default.
• W2171149082 cites W2111754589 @default.
• W2171149082 cites W2115400483 @default.
• W2171149082 cites W2127332345 @default.
• W2171149082 cites W2159355068 @default.
• W2171149082 doi "https://doi.org/10.3109/10428194.2011.639878" @default.
• W2171149082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22080757" @default.
• W2171149082 hasPublicationYear "2012" @default.
• W2171149082 type Work @default.
• W2171149082 sameAs 2171149082 @default.
• W2171149082 citedByCount "7" @default.
• W2171149082 countsByYear W21711490822014 @default.
• W2171149082 countsByYear W21711490822015 @default.
• W2171149082 countsByYear W21711490822016 @default.
• W2171149082 countsByYear W21711490822019 @default.
• W2171149082 crossrefType "journal-article" @default.
• W2171149082 hasAuthorship W2171149082A5019728385 @default.
• W2171149082 hasAuthorship W2171149082A5035426858 @default.
• W2171149082 hasAuthorship W2171149082A5043417417 @default.
• W2171149082 hasAuthorship W2171149082A5050104014 @default.
• W2171149082 hasAuthorship W2171149082A5052937049 @default.
• W2171149082 hasAuthorship W2171149082A5057847328 @default.
• W2171149082 hasAuthorship W2171149082A5070483364 @default.
• W2171149082 hasAuthorship W2171149082A5072456422 @default.
• W2171149082 hasConcept C104317684 @default.
• W2171149082 hasConcept C203014093 @default.
• W2171149082 hasConcept C2777928532 @default.
• W2171149082 hasConcept C2778461978 @default.
• W2171149082 hasConcept C2778729363 @default.
• W2171149082 hasConcept C2779282312 @default.
• W2171149082 hasConcept C2780007613 @default.
• W2171149082 hasConcept C2780817109 @default.
• W2171149082 hasConcept C501734568 @default.
• W2171149082 hasConcept C502942594 @default.
• W2171149082 hasConcept C54355233 @default.
• W2171149082 hasConcept C71924100 @default.
• W2171149082 hasConcept C86803240 @default.
• W2171149082 hasConceptScore W2171149082C104317684 @default.
• W2171149082 hasConceptScore W2171149082C203014093 @default.
• W2171149082 hasConceptScore W2171149082C2777928532 @default.
• W2171149082 hasConceptScore W2171149082C2778461978 @default.
• W2171149082 hasConceptScore W2171149082C2778729363 @default.
• W2171149082 hasConceptScore W2171149082C2779282312 @default.
• W2171149082 hasConceptScore W2171149082C2780007613 @default.
• W2171149082 hasConceptScore W2171149082C2780817109 @default.
• W2171149082 hasConceptScore W2171149082C501734568 @default.
• W2171149082 hasConceptScore W2171149082C502942594 @default.
• W2171149082 hasConceptScore W2171149082C54355233 @default.
• W2171149082 hasConceptScore W2171149082C71924100 @default.
• W2171149082 hasConceptScore W2171149082C86803240 @default.
• W2171149082 hasIssue "6" @default.
• W2171149082 hasLocation W21711490821 @default.
• W2171149082 hasLocation W21711490822 @default.
• W2171149082 hasOpenAccess W2171149082 @default.
• W2171149082 hasPrimaryLocation W21711490821 @default.
• W2171149082 hasRelatedWork W1516501920 @default.
• W2171149082 hasRelatedWork W1972850129 @default.
• W2171149082 hasRelatedWork W2095662532 @default.
• W2171149082 hasRelatedWork W2097160518 @default.
• W2171149082 hasRelatedWork W2385387598 @default.
• W2171149082 hasRelatedWork W3035776639 @default.
• W2171149082 hasRelatedWork W3111068247 @default.
• W2171149082 hasRelatedWork W4247502035 @default.
• W2171149082 hasRelatedWork W4306735370 @default.
• W2171149082 hasRelatedWork W590390087 @default.
• W2171149082 hasVolume "53" @default.
• W2171149082 isParatext "false" @default.
• W2171149082 isRetracted "false" @default.
• W2171149082 magId "2171149082" @default.
• W2171149082 workType "article" @default.