Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171168077> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2171168077 endingPage "215" @default.
- W2171168077 startingPage "207" @default.
- W2171168077 abstract "Bombinakinin M (DLPKINRKGP-bradykinin) is a bradykinin-related peptide purified from skin secretions of the frog Bombina maxima. As previously reported, its biosynthesis is characterized by a tandem repeats with various copy numbers of the peptide and sometimes co-expressed with other structure-function distinguishable peptides. At present study, two novel cDNAs encoding bombinakinin M and its variants were cloned from a cDNA library from the skin of the frog. The encoded two precursor proteins are common in that each contains three repeats of a novel 16-amino acid peptide unit and one copy of kinestatin at their N- and C-terminal parts, respectively. They differ in that the first precursor contains two copies of bombinakinin M and the second one contains one copy of a novel bombinakinin M variant. Bombinakinin M was found to elicit concentration-dependent contractile effects on guinea pig ileum, with an EC50 value of 4 nM that is four times higher than that of bradykinin (1 nM). Interestingly, the synthetic peptide (DYTIRTRLH-amide), as deduced from the 16-amino acid peptide repeats in the newly cloned cDNAs, possessed weak inhibitory activity on the contractile effects of bombinakinin M, but not on that of bradykinin. Furthermore, the newly identified bombinakinin M variant (DLSKMSFLHG-Ile1-bradykinin), did not show contractile activity on guinea pig ileum, but showed potentiation effect on the myotropic activity of bradykinin. In a molar raito of 1:58, it augmented the activity of bradykinin up to two-fold." @default.
- W2171168077 created "2016-06-24" @default.
- W2171168077 creator A5016931193 @default.
- W2171168077 creator A5019869909 @default.
- W2171168077 creator A5023874610 @default.
- W2171168077 creator A5040210816 @default.
- W2171168077 creator A5061314864 @default.
- W2171168077 date "2005-04-01" @default.
- W2171168077 modified "2023-10-17" @default.
- W2171168077 title "Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide" @default.
- W2171168077 cites W1502131457 @default.
- W2171168077 cites W1528801805 @default.
- W2171168077 cites W1963923865 @default.
- W2171168077 cites W1965877687 @default.
- W2171168077 cites W1969355693 @default.
- W2171168077 cites W1971298323 @default.
- W2171168077 cites W1977948341 @default.
- W2171168077 cites W1980478644 @default.
- W2171168077 cites W2049811799 @default.
- W2171168077 cites W2050536230 @default.
- W2171168077 cites W2055834358 @default.
- W2171168077 cites W2056602570 @default.
- W2171168077 cites W2060141833 @default.
- W2171168077 cites W2091567906 @default.
- W2171168077 cites W2094387426 @default.
- W2171168077 cites W2104196801 @default.
- W2171168077 cites W2116588888 @default.
- W2171168077 cites W2135499146 @default.
- W2171168077 cites W2138021049 @default.
- W2171168077 cites W2150499915 @default.
- W2171168077 cites W2166260347 @default.
- W2171168077 doi "https://doi.org/10.1016/j.regpep.2004.12.002" @default.
- W2171168077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15680489" @default.
- W2171168077 hasPublicationYear "2005" @default.
- W2171168077 type Work @default.
- W2171168077 sameAs 2171168077 @default.
- W2171168077 citedByCount "16" @default.
- W2171168077 countsByYear W21711680772013 @default.
- W2171168077 countsByYear W21711680772015 @default.
- W2171168077 countsByYear W21711680772022 @default.
- W2171168077 crossrefType "journal-article" @default.
- W2171168077 hasAuthorship W2171168077A5016931193 @default.
- W2171168077 hasAuthorship W2171168077A5019869909 @default.
- W2171168077 hasAuthorship W2171168077A5023874610 @default.
- W2171168077 hasAuthorship W2171168077A5040210816 @default.
- W2171168077 hasAuthorship W2171168077A5061314864 @default.
- W2171168077 hasConcept C104317684 @default.
- W2171168077 hasConcept C153911025 @default.
- W2171168077 hasConcept C153939273 @default.
- W2171168077 hasConcept C167625842 @default.
- W2171168077 hasConcept C170493617 @default.
- W2171168077 hasConcept C185592680 @default.
- W2171168077 hasConcept C187882448 @default.
- W2171168077 hasConcept C2779281246 @default.
- W2171168077 hasConcept C2779591629 @default.
- W2171168077 hasConcept C515207424 @default.
- W2171168077 hasConcept C55493867 @default.
- W2171168077 hasConcept C86803240 @default.
- W2171168077 hasConceptScore W2171168077C104317684 @default.
- W2171168077 hasConceptScore W2171168077C153911025 @default.
- W2171168077 hasConceptScore W2171168077C153939273 @default.
- W2171168077 hasConceptScore W2171168077C167625842 @default.
- W2171168077 hasConceptScore W2171168077C170493617 @default.
- W2171168077 hasConceptScore W2171168077C185592680 @default.
- W2171168077 hasConceptScore W2171168077C187882448 @default.
- W2171168077 hasConceptScore W2171168077C2779281246 @default.
- W2171168077 hasConceptScore W2171168077C2779591629 @default.
- W2171168077 hasConceptScore W2171168077C515207424 @default.
- W2171168077 hasConceptScore W2171168077C55493867 @default.
- W2171168077 hasConceptScore W2171168077C86803240 @default.
- W2171168077 hasIssue "1-3" @default.
- W2171168077 hasLocation W21711680771 @default.
- W2171168077 hasLocation W21711680772 @default.
- W2171168077 hasOpenAccess W2171168077 @default.
- W2171168077 hasPrimaryLocation W21711680771 @default.
- W2171168077 hasRelatedWork W1565137730 @default.
- W2171168077 hasRelatedWork W1976570971 @default.
- W2171168077 hasRelatedWork W1989739259 @default.
- W2171168077 hasRelatedWork W2019722743 @default.
- W2171168077 hasRelatedWork W2029195436 @default.
- W2171168077 hasRelatedWork W2052920834 @default.
- W2171168077 hasRelatedWork W2089409704 @default.
- W2171168077 hasRelatedWork W2120151291 @default.
- W2171168077 hasRelatedWork W2140021188 @default.
- W2171168077 hasRelatedWork W2427331003 @default.
- W2171168077 hasVolume "127" @default.
- W2171168077 isParatext "false" @default.
- W2171168077 isRetracted "false" @default.
- W2171168077 magId "2171168077" @default.
- W2171168077 workType "article" @default.