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• W2171204703 abstract "Abstract The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/β-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar cell polarity (PCP) signaling in cancer progression, invasion and metastasis, and angiogenesis. This review describes the PCP signaling pathway and its ever-expanding components and modulators, highlights the most recent studies that provide insight into the link between PCP signaling and cancer, and, finally, proposes a model by which PCP signaling may promote cancer development. This review underscores the emerging theme that deregulated PCP signaling contributes to tumorigenesis, providing new potential targets for cancer therapy. [Mol Cancer Ther 2009;8(8):2103–9]" @default.
• W2171204703 created "2016-06-24" @default.
• W2171204703 creator A5082531489 @default.
• W2171204703 date "2009-08-01" @default.
• W2171204703 modified "2023-10-12" @default.
• W2171204703 title "Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy" @default.
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• W2171204703 doi "https://doi.org/10.1158/1535-7163.mct-09-0282" @default.
• W2171204703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19671746" @default.
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