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• W2171225274 abstract "Peroxiredoxins (Prxs) are important peroxidases associated with both antioxidant protection and redox signaling. They use a conserved Cys residue to reduce peroxide substrates. The Prxs have a remarkably high catalytic efficiency that makes them a dominant player in cell-wide peroxide reduction, but the origins of their high activity have been mysterious. We present here a novel structure of human PrxV at 1.45 A resolution that has a dithiothreitol bound in the active site with its diol moiety mimicking the two oxygens of a peroxide substrate. This suggests diols and similar di-oxygen compounds as a novel class of competitive inhibitors for the Prxs. Common features of this and other structures containing peroxide, peroxide-mimicking ligands, or peroxide-mimicking water molecules reveal hydrogen bonding and steric factors that promote its high reactivity by creating an oxygen track along which the peroxide oxygens move as the reaction proceeds. Key insights include how the active-site microenvironment activates both the peroxidatic cysteine side chain and the peroxide substrate and how it is exquisitely well suited to stabilize the transition state of the in-line S(N)2 substitution reaction that is peroxidation." @default.
• W2171225274 created "2016-06-24" @default.
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• W2171225274 date "2010-09-01" @default.
• W2171225274 modified "2023-09-25" @default.
• W2171225274 title "Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization" @default.
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• W2171225274 doi "https://doi.org/10.1016/j.jmb.2010.07.022" @default.
• W2171225274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2941395" @default.
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