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• W2171241319 endingPage "2230" @default.
• W2171241319 startingPage "2225" @default.
• W2171241319 abstract "Hormone-sensitive lipase (HSL) is expressed and enzymatically active in β-cells and has been proposed to be involved in the generation of the lipid-derived signal that seems to be necessary for glucose-stimulated insulin secretion. In this study, we investigated whether the expression of HSL in INS-1 cells and in rat islets is affected by exposure to high glucose concentrations. Incubation of INS-1 cells in 25 mmol/l glucose for 16 and 32 h induced HSL protein expression twofold, whereas no effect was observed after 4 and 8 h of incubation. The HSL activity, defined as the diglyceride lipase activity inhibited by anti-rat HSL antibodies, constituted ∼25% of total diglyceride lipase activity and was induced to a similar extent as HSL protein levels. The glucose effect at 16 h on HSL protein expression level was confirmed in freshly isolated rat islets. Exposure of INS-1 cells to different glucose concentrations for 16 h showed that the inductive effect on HSL protein levels was maximum at 20 mmol/l glucose (2- to 2.5-fold). Northern blot analysis demonstrated a more than threefold elevation of HSL mRNA levels. The induction was blocked by actinomycin D, and the half-life of the transcript seemed to be unchanged by high glucose, suggesting a transcriptional nature of the glucose effect on HSL gene expression. The nonmetabolizable glucose analog 2-deoxyglucose, which has no mitogenic effect, induced HSL ∼1.3-fold, whereas mannose was similar to glucose, stimulating HSL expression 1.7- to 2-fold. The results suggest that HSL is involved in the β-cell responses to hyperglycemia and also in generating the lipid signal that is needed in stimulus-secretion coupling." @default.
• W2171241319 created "2016-06-24" @default.
• W2171241319 creator A5016042114 @default.
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• W2171241319 date "2001-10-01" @default.
• W2171241319 modified "2023-10-05" @default.
• W2171241319 title "The Expression of Hormone-Sensitive Lipase in Clonal β-Cells and Rat Islets Is Induced by Long-Term Exposure to High Glucose" @default.
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• W2171241319 doi "https://doi.org/10.2337/diabetes.50.10.2225" @default.
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