Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171242022> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2171242022 endingPage "3181" @default.
- W2171242022 startingPage "3177" @default.
- W2171242022 abstract "Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of alpha- and beta-globin chains that form hemoglobin. We have disrupted the major adult beta-globin gene (b1) in mouse embryonic stem cells by using homologous recombination to insert selectable sequences into the gene. Mice homozygous for this insertional disruption of the b1 gene (Hbbth-2/Hbbth-2) are severely anemic and die perinatally. In contrast, approximately 60% of mice homozygous for deletion of the same gene (Hbbth-1/Hbbth-1) survive to adulthood and are much less anemic [Skow, L. C., Burkhart, B. A., Johnson, F. M., Popp, R. A., Goldberg, S. Z., Anderson, W. F., Barnett, L. B. & Lewis, S. E. (1983) Cell 34, 1043-1052]. These different phenotypes have implications for the control of beta-globin gene expression." @default.
- W2171242022 created "2016-06-24" @default.
- W2171242022 creator A5012578178 @default.
- W2171242022 creator A5044696675 @default.
- W2171242022 creator A5070335657 @default.
- W2171242022 date "1993-04-15" @default.
- W2171242022 modified "2023-10-12" @default.
- W2171242022 title "Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene." @default.
- W2171242022 cites W1597508878 @default.
- W2171242022 cites W1601854459 @default.
- W2171242022 cites W1615568676 @default.
- W2171242022 cites W1928245765 @default.
- W2171242022 cites W1983237714 @default.
- W2171242022 cites W1983844859 @default.
- W2171242022 cites W2010264165 @default.
- W2171242022 cites W2053700159 @default.
- W2171242022 cites W2063599822 @default.
- W2171242022 cites W2078575583 @default.
- W2171242022 cites W2084364631 @default.
- W2171242022 cites W2085631191 @default.
- W2171242022 cites W2091399084 @default.
- W2171242022 cites W2094306229 @default.
- W2171242022 cites W2098797177 @default.
- W2171242022 cites W2104163133 @default.
- W2171242022 cites W2125365759 @default.
- W2171242022 cites W2137854193 @default.
- W2171242022 cites W2145136607 @default.
- W2171242022 cites W2198757862 @default.
- W2171242022 cites W2247225447 @default.
- W2171242022 cites W2410463669 @default.
- W2171242022 cites W2786344329 @default.
- W2171242022 doi "https://doi.org/10.1073/pnas.90.8.3177" @default.
- W2171242022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/46262" @default.
- W2171242022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8475058" @default.
- W2171242022 hasPublicationYear "1993" @default.
- W2171242022 type Work @default.
- W2171242022 sameAs 2171242022 @default.
- W2171242022 citedByCount "77" @default.
- W2171242022 countsByYear W21712420222013 @default.
- W2171242022 countsByYear W21712420222015 @default.
- W2171242022 countsByYear W21712420222016 @default.
- W2171242022 countsByYear W21712420222017 @default.
- W2171242022 countsByYear W21712420222019 @default.
- W2171242022 countsByYear W21712420222021 @default.
- W2171242022 countsByYear W21712420222022 @default.
- W2171242022 countsByYear W21712420222023 @default.
- W2171242022 crossrefType "journal-article" @default.
- W2171242022 hasAuthorship W2171242022A5012578178 @default.
- W2171242022 hasAuthorship W2171242022A5044696675 @default.
- W2171242022 hasAuthorship W2171242022A5070335657 @default.
- W2171242022 hasBestOaLocation W21712420221 @default.
- W2171242022 hasConcept C104317684 @default.
- W2171242022 hasConcept C125996951 @default.
- W2171242022 hasConcept C127716648 @default.
- W2171242022 hasConcept C153911025 @default.
- W2171242022 hasConcept C2777799968 @default.
- W2171242022 hasConcept C54355233 @default.
- W2171242022 hasConcept C86803240 @default.
- W2171242022 hasConceptScore W2171242022C104317684 @default.
- W2171242022 hasConceptScore W2171242022C125996951 @default.
- W2171242022 hasConceptScore W2171242022C127716648 @default.
- W2171242022 hasConceptScore W2171242022C153911025 @default.
- W2171242022 hasConceptScore W2171242022C2777799968 @default.
- W2171242022 hasConceptScore W2171242022C54355233 @default.
- W2171242022 hasConceptScore W2171242022C86803240 @default.
- W2171242022 hasIssue "8" @default.
- W2171242022 hasLocation W21712420221 @default.
- W2171242022 hasLocation W21712420222 @default.
- W2171242022 hasLocation W21712420223 @default.
- W2171242022 hasLocation W21712420224 @default.
- W2171242022 hasLocation W21712420225 @default.
- W2171242022 hasOpenAccess W2171242022 @default.
- W2171242022 hasPrimaryLocation W21712420221 @default.
- W2171242022 hasRelatedWork W1530402712 @default.
- W2171242022 hasRelatedWork W2060631033 @default.
- W2171242022 hasRelatedWork W2070086824 @default.
- W2171242022 hasRelatedWork W2121760608 @default.
- W2171242022 hasRelatedWork W2125731289 @default.
- W2171242022 hasRelatedWork W2132993604 @default.
- W2171242022 hasRelatedWork W2143066563 @default.
- W2171242022 hasRelatedWork W2157166663 @default.
- W2171242022 hasRelatedWork W3032357680 @default.
- W2171242022 hasRelatedWork W4245259083 @default.
- W2171242022 hasVolume "90" @default.
- W2171242022 isParatext "false" @default.
- W2171242022 isRetracted "false" @default.
- W2171242022 magId "2171242022" @default.
- W2171242022 workType "article" @default.