FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171244484> ?p ?o ?g. }

• W2171244484 endingPage "2680" @default.
• W2171244484 startingPage "2673" @default.
• W2171244484 abstract "Age-related macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision loss in the elderly, is associated with polymorphisms in the LOC387715/ARMS2 and HTRA1 genes on 10q26. Like humans, macaque monkeys possess a macula and develop age-related macular pathologies including drusen, the phenotypic hallmark of AMD. We genotyped a cohort of 137 unrelated rhesus macaques with and without macular drusen. As in humans, one variant within LOC387715/ARMS2 and one in HTRA1 were significantly associated with affected status. HTRA1 and the predicted LOC387715/ARMS2 gene were both transcribed in rhesus and human retina and retinal pigment epithelium. Among several primate species, orthologous exons for the human LOC387715/ARMS2 gene were present only in Old World monkeys and apes. In functional analyses, the disease-associated HTRA1 polymorphism resulted in a 2-fold increase in gene expression, supporting a role in pathogenesis. These results demonstrate that two genes associated with AMD in humans are also associated with macular disease in rhesus macaques and that one of these genes is specific to higher primates. This is the first evidence that humans and macaques share the same genetic susceptibility factors for a common complex disease." @default.
• W2171244484 created "2016-06-24" @default.
• W2171244484 creator A5019163181 @default.
• W2171244484 creator A5024550235 @default.
• W2171244484 creator A5029417521 @default.
• W2171244484 creator A5036923516 @default.
• W2171244484 creator A5037261879 @default.
• W2171244484 creator A5042072885 @default.
• W2171244484 creator A5050264219 @default.
• W2171244484 creator A5066108340 @default.
• W2171244484 creator A5070480696 @default.
• W2171244484 creator A5078572636 @default.
• W2171244484 creator A5081945819 @default.
• W2171244484 date "2008-05-23" @default.
• W2171244484 modified "2023-10-09" @default.
• W2171244484 title "Rhesus monkeys and humans share common susceptibility genes for age-related macular disease" @default.
• W2171244484 cites W1489931628 @default.
• W2171244484 cites W1984944701 @default.
• W2171244484 cites W1993044911 @default.
• W2171244484 cites W1994244877 @default.
• W2171244484 cites W200886222 @default.
• W2171244484 cites W2017350165 @default.
• W2171244484 cites W2032768676 @default.
• W2171244484 cites W2059935183 @default.
• W2171244484 cites W2060542745 @default.
• W2171244484 cites W2100448296 @default.
• W2171244484 cites W2106901733 @default.
• W2171244484 cites W2160429819 @default.
• W2171244484 cites W2566154985 @default.
• W2171244484 cites W4238550599 @default.
• W2171244484 doi "https://doi.org/10.1093/hmg/ddn167" @default.
• W2171244484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2733804" @default.
• W2171244484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18535016" @default.
• W2171244484 hasPublicationYear "2008" @default.
• W2171244484 type Work @default.
• W2171244484 sameAs 2171244484 @default.
• W2171244484 citedByCount "96" @default.
• W2171244484 countsByYear W21712444842012 @default.
• W2171244484 countsByYear W21712444842013 @default.
• W2171244484 countsByYear W21712444842014 @default.
• W2171244484 countsByYear W21712444842015 @default.
• W2171244484 countsByYear W21712444842016 @default.
• W2171244484 countsByYear W21712444842017 @default.
• W2171244484 countsByYear W21712444842018 @default.
• W2171244484 countsByYear W21712444842019 @default.
• W2171244484 countsByYear W21712444842020 @default.
• W2171244484 countsByYear W21712444842021 @default.
• W2171244484 countsByYear W21712444842022 @default.
• W2171244484 countsByYear W21712444842023 @default.
• W2171244484 crossrefType "journal-article" @default.
• W2171244484 hasAuthorship W2171244484A5019163181 @default.
• W2171244484 hasAuthorship W2171244484A5024550235 @default.
• W2171244484 hasAuthorship W2171244484A5029417521 @default.
• W2171244484 hasAuthorship W2171244484A5036923516 @default.
• W2171244484 hasAuthorship W2171244484A5037261879 @default.
• W2171244484 hasAuthorship W2171244484A5042072885 @default.
• W2171244484 hasAuthorship W2171244484A5050264219 @default.
• W2171244484 hasAuthorship W2171244484A5066108340 @default.
• W2171244484 hasAuthorship W2171244484A5070480696 @default.
• W2171244484 hasAuthorship W2171244484A5078572636 @default.
• W2171244484 hasAuthorship W2171244484A5081945819 @default.
• W2171244484 hasBestOaLocation W21712444841 @default.
• W2171244484 hasConcept C104317684 @default.
• W2171244484 hasConcept C118487528 @default.
• W2171244484 hasConcept C142724271 @default.
• W2171244484 hasConcept C169760540 @default.
• W2171244484 hasConcept C2776403814 @default.
• W2171244484 hasConcept C2777093970 @default.
• W2171244484 hasConcept C2778024200 @default.
• W2171244484 hasConcept C2778950215 @default.
• W2171244484 hasConcept C2779093074 @default.
• W2171244484 hasConcept C2779134260 @default.
• W2171244484 hasConcept C2779175743 @default.
• W2171244484 hasConcept C2780604041 @default.
• W2171244484 hasConcept C36823959 @default.
• W2171244484 hasConcept C54355233 @default.
• W2171244484 hasConcept C69991583 @default.
• W2171244484 hasConcept C71924100 @default.
• W2171244484 hasConcept C86803240 @default.
• W2171244484 hasConceptScore W2171244484C104317684 @default.
• W2171244484 hasConceptScore W2171244484C118487528 @default.
• W2171244484 hasConceptScore W2171244484C142724271 @default.
• W2171244484 hasConceptScore W2171244484C169760540 @default.
• W2171244484 hasConceptScore W2171244484C2776403814 @default.
• W2171244484 hasConceptScore W2171244484C2777093970 @default.
• W2171244484 hasConceptScore W2171244484C2778024200 @default.
• W2171244484 hasConceptScore W2171244484C2778950215 @default.
• W2171244484 hasConceptScore W2171244484C2779093074 @default.
• W2171244484 hasConceptScore W2171244484C2779134260 @default.
• W2171244484 hasConceptScore W2171244484C2779175743 @default.
• W2171244484 hasConceptScore W2171244484C2780604041 @default.
• W2171244484 hasConceptScore W2171244484C36823959 @default.
• W2171244484 hasConceptScore W2171244484C54355233 @default.
• W2171244484 hasConceptScore W2171244484C69991583 @default.
• W2171244484 hasConceptScore W2171244484C71924100 @default.
• W2171244484 hasConceptScore W2171244484C86803240 @default.
• W2171244484 hasIssue "17" @default.
• W2171244484 hasLocation W21712444841 @default.

• next