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- W2171248049 abstract "Significance Polymorphisms in the protein tyrosine phosphatase (PTP)σ ( PTPRS ) gene were previously shown to be associated with inflammatory bowel disease (IBD), and PTPσ knockout mice exhibit an intestinal IBD phenotype, but how PTPσ is involved in IBD is unknown. Our studies here show that PTPσ knockout mice exhibit a leaky intestinal epithelium that may explain the observed IBD phenotype. We further identify the junctional protein ezrin as an in vivo intestinal substrate for PTPσ and identify specific tyrosine phosphorylation sites on ezrin that are targeted by PTPσ, leading to removal of ezrin from its plasma membrane localization. These studies help explain the role of PTPσ in IBD." @default.
- W2171248049 created "2016-06-24" @default.
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- W2171248049 date "2014-01-02" @default.
- W2171248049 modified "2023-10-13" @default.
- W2171248049 title "Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability" @default.
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- W2171248049 doi "https://doi.org/10.1073/pnas.1315017111" @default.
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