Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171279500> ?p ?o ?g. }
- W2171279500 endingPage "1470" @default.
- W2171279500 startingPage "1460" @default.
- W2171279500 abstract "Cationic lipids have been regarded as an important type of non-viral gene vector; to develop novel lipids with high transfection efficiency (TE) and biocompatibility is of great importance. A series of cyclen-based cationic lipids bearing double hydrophobic tails were synthesized herein. To study their structure-activity relationship (SAR), several analogs including the amide-contained double-tailed lipids, lipids containing ester bonds with the reverse direction, and lipids with a single tail were also prepared. Several assays were used to study their interactions with plasmid DNA, and results reveal that these lipids could smoothly condense DNA into nanosized particles. CCK-8-based cell viability assays showed relatively lower cytotoxicity of the lipoplexes compared to commercially available Lipofectamine 2000. In vitro transfection assays exhibited that some of the lipids (5a, 5b and 8b) may give excellent TEs, which were up to 10 times higher than Lipofectamine 2000. SAR of these lipids was studied in detail by investigating the effects of several structural aspects including the chain length and saturation degree, chain numbers, the type of linkage bond, and orientation of ester bonds. The results not only demonstrate that these lipids might be promising non-viral gene vectors, but also afford us clues for further optimization of lipidic gene delivery materials." @default.
- W2171279500 created "2016-06-24" @default.
- W2171279500 creator A5007613197 @default.
- W2171279500 creator A5022826260 @default.
- W2171279500 creator A5024693956 @default.
- W2171279500 creator A5043050875 @default.
- W2171279500 creator A5062824144 @default.
- W2171279500 creator A5082141785 @default.
- W2171279500 date "2014-01-01" @default.
- W2171279500 modified "2023-09-29" @default.
- W2171279500 title "Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery" @default.
- W2171279500 cites W1964614378 @default.
- W2171279500 cites W1966647637 @default.
- W2171279500 cites W1968864573 @default.
- W2171279500 cites W1974769389 @default.
- W2171279500 cites W1979194035 @default.
- W2171279500 cites W1980245624 @default.
- W2171279500 cites W1983094634 @default.
- W2171279500 cites W1986227359 @default.
- W2171279500 cites W1996491430 @default.
- W2171279500 cites W1998697301 @default.
- W2171279500 cites W2002209149 @default.
- W2171279500 cites W2005446730 @default.
- W2171279500 cites W2016259491 @default.
- W2171279500 cites W2023287503 @default.
- W2171279500 cites W2023720328 @default.
- W2171279500 cites W2027774836 @default.
- W2171279500 cites W2033437031 @default.
- W2171279500 cites W2045812803 @default.
- W2171279500 cites W2047289354 @default.
- W2171279500 cites W2053096200 @default.
- W2171279500 cites W2057917816 @default.
- W2171279500 cites W2060571512 @default.
- W2171279500 cites W2062121623 @default.
- W2171279500 cites W2062564039 @default.
- W2171279500 cites W2063072125 @default.
- W2171279500 cites W2067296473 @default.
- W2171279500 cites W2070693578 @default.
- W2171279500 cites W2071092270 @default.
- W2171279500 cites W2078362380 @default.
- W2171279500 cites W2081558960 @default.
- W2171279500 cites W2085380241 @default.
- W2171279500 cites W2087194381 @default.
- W2171279500 cites W2093387817 @default.
- W2171279500 cites W2123478701 @default.
- W2171279500 cites W2141779360 @default.
- W2171279500 cites W2313202297 @default.
- W2171279500 cites W2321877594 @default.
- W2171279500 cites W2334178706 @default.
- W2171279500 cites W2950650597 @default.
- W2171279500 cites W61869633 @default.
- W2171279500 doi "https://doi.org/10.1039/c4bm00174e" @default.
- W2171279500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32481921" @default.
- W2171279500 hasPublicationYear "2014" @default.
- W2171279500 type Work @default.
- W2171279500 sameAs 2171279500 @default.
- W2171279500 citedByCount "24" @default.
- W2171279500 countsByYear W21712795002015 @default.
- W2171279500 countsByYear W21712795002016 @default.
- W2171279500 countsByYear W21712795002017 @default.
- W2171279500 countsByYear W21712795002018 @default.
- W2171279500 countsByYear W21712795002019 @default.
- W2171279500 countsByYear W21712795002020 @default.
- W2171279500 countsByYear W21712795002021 @default.
- W2171279500 countsByYear W21712795002022 @default.
- W2171279500 countsByYear W21712795002023 @default.
- W2171279500 crossrefType "journal-article" @default.
- W2171279500 hasAuthorship W2171279500A5007613197 @default.
- W2171279500 hasAuthorship W2171279500A5022826260 @default.
- W2171279500 hasAuthorship W2171279500A5024693956 @default.
- W2171279500 hasAuthorship W2171279500A5043050875 @default.
- W2171279500 hasAuthorship W2171279500A5062824144 @default.
- W2171279500 hasAuthorship W2171279500A5082141785 @default.
- W2171279500 hasConcept C104317684 @default.
- W2171279500 hasConcept C12554922 @default.
- W2171279500 hasConcept C135983454 @default.
- W2171279500 hasConcept C178790620 @default.
- W2171279500 hasConcept C183882617 @default.
- W2171279500 hasConcept C185154212 @default.
- W2171279500 hasConcept C185592680 @default.
- W2171279500 hasConcept C2777230088 @default.
- W2171279500 hasConcept C2777459166 @default.
- W2171279500 hasConcept C40767141 @default.
- W2171279500 hasConcept C49923114 @default.
- W2171279500 hasConcept C54009773 @default.
- W2171279500 hasConcept C552990157 @default.
- W2171279500 hasConcept C55493867 @default.
- W2171279500 hasConcept C68381374 @default.
- W2171279500 hasConcept C71240020 @default.
- W2171279500 hasConcept C86803240 @default.
- W2171279500 hasConcept C92087593 @default.
- W2171279500 hasConceptScore W2171279500C104317684 @default.
- W2171279500 hasConceptScore W2171279500C12554922 @default.
- W2171279500 hasConceptScore W2171279500C135983454 @default.
- W2171279500 hasConceptScore W2171279500C178790620 @default.
- W2171279500 hasConceptScore W2171279500C183882617 @default.
- W2171279500 hasConceptScore W2171279500C185154212 @default.
- W2171279500 hasConceptScore W2171279500C185592680 @default.