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• W2171292941 startingPage "4093" @default.
• W2171292941 abstract "The increased incidence of human immunodeficiency virus (HIV)/AIDS disease in women aged 15 to 49 years has identified the urgent need for a female-controlled, efficacious, and safe vaginal topical microbicide. To meet this challenge, sophorolipid (SL) produced by Candida bombicola and its structural analogs have been studied in this report for their spermicidal, anti-HIV, and cytotoxic activities. The sophorolipid diacetate ethyl ester derivative is the most potent spermicidal and virucidal agent of the series of SLs studied. Its virucidal activity against HIV and sperm-immobilizing activity against human semen are similar to those of nonoxynol-9. However, it also induced enough vaginal cell toxicity to raise concerns about its applicability for long-term microbicidal contraception. Its structure-activity relationship has been established for creating new analogs with less cytotoxicity and higher activity." @default.
• W2171292941 created "2016-06-24" @default.
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• W2171292941 date "2005-10-01" @default.
• W2171292941 modified "2023-10-10" @default.
• W2171292941 title "Sophorolipids, Microbial Glycolipids with Anti-Human Immunodeficiency Virus and Sperm-Immobilizing Activities" @default.
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• W2171292941 doi "https://doi.org/10.1128/aac.49.10.4093-4100.2005" @default.
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