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- W2171294133 abstract "The treatment of malignancies like acute myeloid leukemia (AML) is often complicated by the heterogeneity of the disease and the mechanisms of the disease progression. This heterogeneity is often not reflected in standard treatment approaches which provide predictable outcomes in the majority of patients but fail in individual cases even with high-dose multi-agent chemotherapy regimens and allogeneic stem cell transplantation. Further, the unselective effect of chemotherapy causes high treatment-related toxicity and accelerates the risk of infection during prolonged pancytopenia, preventing further dose escalation. Despite rapid progress in therapeutic strategies, the fatality of high-grade malignancies remains enormous.Adhesive interactions trigger signal transduction pathway activation and this prevents the apoptosis of both normal and malignant cells. A correlation between expression of defined adhesion molecules and patient outcome has been found for several malignant diseases including AML. We aim to describe how disruption of these signalling pathways can overcome the high resistance to treatment and increase the selectivity of targeting malignant cells. This could effectively reduce the overall treatment-related toxicity and improve the general outcome.Adhesion molecules facilitate growth of malignant diseases. This review provides a deeper insight into these processes. Modulation of adhesion molecules-mediated interactions is an innovative and feasible approach in treatment of AML and many other malignancies. Due to expected low toxicity it is an acceptable addition to standard chemotherapeutical regimens for all age groups of patients. This approach could improve the overall treatment outcome in the future." @default.
- W2171294133 created "2016-06-24" @default.
- W2171294133 creator A5009751029 @default.
- W2171294133 creator A5048516274 @default.
- W2171294133 creator A5068854434 @default.
- W2171294133 date "2015-03-09" @default.
- W2171294133 modified "2023-10-02" @default.
- W2171294133 title "The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review" @default.
- W2171294133 cites W138721633 @default.
- W2171294133 cites W1510898037 @default.
- W2171294133 cites W1522330946 @default.
- W2171294133 cites W1537188001 @default.
- W2171294133 cites W1557905573 @default.
- W2171294133 cites W1576773659 @default.
- W2171294133 cites W1753018053 @default.
- W2171294133 cites W1841040774 @default.
- W2171294133 cites W1853590226 @default.
- W2171294133 cites W1915521129 @default.
- W2171294133 cites W1916911965 @default.
- W2171294133 cites W1964638756 @default.
- W2171294133 cites W1965037168 @default.
- W2171294133 cites W1966684157 @default.
- W2171294133 cites W1975097950 @default.
- W2171294133 cites W1975444882 @default.
- W2171294133 cites W1976058007 @default.
- W2171294133 cites W1977509166 @default.
- W2171294133 cites W1978321902 @default.
- W2171294133 cites W1978333303 @default.
- W2171294133 cites W1979421565 @default.
- W2171294133 cites W1980095074 @default.
- W2171294133 cites W1980267743 @default.
- W2171294133 cites W1981415835 @default.
- W2171294133 cites W1983307337 @default.
- W2171294133 cites W1983644209 @default.
- W2171294133 cites W1985190362 @default.
- W2171294133 cites W1986557797 @default.
- W2171294133 cites W1987081782 @default.
- W2171294133 cites W1988338839 @default.
- W2171294133 cites W1988339890 @default.
- W2171294133 cites W1993308058 @default.
- W2171294133 cites W1993957513 @default.
- W2171294133 cites W1994674018 @default.
- W2171294133 cites W1994915831 @default.
- W2171294133 cites W1998973639 @default.
- W2171294133 cites W1999063996 @default.
- W2171294133 cites W1999330408 @default.
- W2171294133 cites W2000765871 @default.
- W2171294133 cites W2000980282 @default.
- W2171294133 cites W2002259314 @default.
- W2171294133 cites W2006608487 @default.
- W2171294133 cites W2006964316 @default.
- W2171294133 cites W2009059430 @default.
- W2171294133 cites W2009245880 @default.
- W2171294133 cites W2010308216 @default.
- W2171294133 cites W2010439346 @default.
- W2171294133 cites W2011718237 @default.
- W2171294133 cites W2015314849 @default.
- W2171294133 cites W2022601640 @default.
- W2171294133 cites W2024858981 @default.
- W2171294133 cites W2025019998 @default.
- W2171294133 cites W2025177279 @default.
- W2171294133 cites W2026705594 @default.
- W2171294133 cites W2028340936 @default.
- W2171294133 cites W2030385954 @default.
- W2171294133 cites W2032297112 @default.
- W2171294133 cites W2033204767 @default.
- W2171294133 cites W2034687111 @default.
- W2171294133 cites W2035614371 @default.
- W2171294133 cites W2035724007 @default.
- W2171294133 cites W2037841266 @default.
- W2171294133 cites W2042489614 @default.
- W2171294133 cites W2043046186 @default.
- W2171294133 cites W2043402587 @default.
- W2171294133 cites W2048185125 @default.
- W2171294133 cites W2050959645 @default.
- W2171294133 cites W2051191991 @default.
- W2171294133 cites W2052227923 @default.
- W2171294133 cites W2054322335 @default.
- W2171294133 cites W2055044750 @default.
- W2171294133 cites W2056761639 @default.
- W2171294133 cites W2058554403 @default.
- W2171294133 cites W2060529002 @default.
- W2171294133 cites W2061464560 @default.
- W2171294133 cites W2072254145 @default.
- W2171294133 cites W2072872856 @default.
- W2171294133 cites W2073874802 @default.
- W2171294133 cites W2074143088 @default.
- W2171294133 cites W2075990374 @default.
- W2171294133 cites W2076532644 @default.
- W2171294133 cites W2079667526 @default.
- W2171294133 cites W2081760707 @default.
- W2171294133 cites W2085875957 @default.
- W2171294133 cites W2086938816 @default.
- W2171294133 cites W2087189971 @default.
- W2171294133 cites W2087372329 @default.
- W2171294133 cites W2088618795 @default.
- W2171294133 cites W2089394059 @default.
- W2171294133 cites W2090871204 @default.