Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171297737> ?p ?o ?g. }
- W2171297737 endingPage "1227" @default.
- W2171297737 startingPage "1219" @default.
- W2171297737 abstract "It is generally considered that mitochondria regulate cardiac cell contractility by providing ATP for cellular ATPases and by participating in Ca2+ homeostasis. However, other possible mechanisms by which mitochondria can influence contractility have been largely overlooked. Here, we demonstrate that inhibition of the mitochondrial electron transport chain strongly increases Ca2+-dependent and independent isometric force development in rat ventricular fibers with selectively permeabilized sarcolemma. This effect is unrelated to the ATP-generating activity of mitochondria or Ca2+ homeostasis. Furthermore, various conditions that increase K+ accumulation in the mitochondrial matrix (activation of ATP- or Ca2+-dependent K+ channels as well as inhibition of the K+ efflux pathway via the K+/H+ exchanger) induce a similar mechanical response. Modulators of mitochondrial function that augment isometric force also cause swelling of mitochondria in the vicinity of myofibrils in situ, as shown by confocal microscopy. Osmotic compression of intracellular structures abolishes the effect of mitochondria-induced force modulation, suggesting a mechanical basis for the interaction between the organelles. These findings suggest a novel mechanism for cellular regulation of myofibrillar function, whereby increases in mitochondrial volume can impose mechanical constraints inside the cell, leading to an increase in force developed by myofibrils." @default.
- W2171297737 created "2016-06-24" @default.
- W2171297737 creator A5077187404 @default.
- W2171297737 creator A5084581276 @default.
- W2171297737 creator A5085919532 @default.
- W2171297737 creator A5088354411 @default.
- W2171297737 date "2004-08-01" @default.
- W2171297737 modified "2023-10-18" @default.
- W2171297737 title "A novel mechanism of regulation of cardiac contractility by mitochondrial functional state" @default.
- W2171297737 cites W1482216160 @default.
- W2171297737 cites W1509382673 @default.
- W2171297737 cites W1522450427 @default.
- W2171297737 cites W1907942773 @default.
- W2171297737 cites W1920479129 @default.
- W2171297737 cites W1922241518 @default.
- W2171297737 cites W1973106821 @default.
- W2171297737 cites W1986207611 @default.
- W2171297737 cites W2012751980 @default.
- W2171297737 cites W2013958930 @default.
- W2171297737 cites W2024104987 @default.
- W2171297737 cites W2025333162 @default.
- W2171297737 cites W2025975686 @default.
- W2171297737 cites W2046419357 @default.
- W2171297737 cites W2066987581 @default.
- W2171297737 cites W2073182113 @default.
- W2171297737 cites W2074570665 @default.
- W2171297737 cites W2080713254 @default.
- W2171297737 cites W2085754322 @default.
- W2171297737 cites W2089538133 @default.
- W2171297737 cites W2094954202 @default.
- W2171297737 cites W2096251685 @default.
- W2171297737 cites W2111732786 @default.
- W2171297737 cites W2114439291 @default.
- W2171297737 cites W2120327065 @default.
- W2171297737 cites W2130325124 @default.
- W2171297737 cites W2136037597 @default.
- W2171297737 cites W2141188578 @default.
- W2171297737 cites W2141473099 @default.
- W2171297737 cites W2150724213 @default.
- W2171297737 cites W2152553738 @default.
- W2171297737 cites W2155543505 @default.
- W2171297737 cites W2169288708 @default.
- W2171297737 cites W2184484397 @default.
- W2171297737 cites W4250737642 @default.
- W2171297737 doi "https://doi.org/10.1096/fj.04-1508com" @default.
- W2171297737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15284222" @default.
- W2171297737 hasPublicationYear "2004" @default.
- W2171297737 type Work @default.
- W2171297737 sameAs 2171297737 @default.
- W2171297737 citedByCount "28" @default.
- W2171297737 countsByYear W21712977372012 @default.
- W2171297737 countsByYear W21712977372013 @default.
- W2171297737 countsByYear W21712977372014 @default.
- W2171297737 countsByYear W21712977372015 @default.
- W2171297737 countsByYear W21712977372018 @default.
- W2171297737 countsByYear W21712977372019 @default.
- W2171297737 countsByYear W21712977372020 @default.
- W2171297737 countsByYear W21712977372021 @default.
- W2171297737 countsByYear W21712977372022 @default.
- W2171297737 crossrefType "journal-article" @default.
- W2171297737 hasAuthorship W2171297737A5077187404 @default.
- W2171297737 hasAuthorship W2171297737A5084581276 @default.
- W2171297737 hasAuthorship W2171297737A5085919532 @default.
- W2171297737 hasAuthorship W2171297737A5088354411 @default.
- W2171297737 hasConcept C103486182 @default.
- W2171297737 hasConcept C12554922 @default.
- W2171297737 hasConcept C134018914 @default.
- W2171297737 hasConcept C168240541 @default.
- W2171297737 hasConcept C185592680 @default.
- W2171297737 hasConcept C199096232 @default.
- W2171297737 hasConcept C207200792 @default.
- W2171297737 hasConcept C28859421 @default.
- W2171297737 hasConcept C39133596 @default.
- W2171297737 hasConcept C42407357 @default.
- W2171297737 hasConcept C55493867 @default.
- W2171297737 hasConcept C7301908 @default.
- W2171297737 hasConcept C79879829 @default.
- W2171297737 hasConcept C86803240 @default.
- W2171297737 hasConcept C95444343 @default.
- W2171297737 hasConceptScore W2171297737C103486182 @default.
- W2171297737 hasConceptScore W2171297737C12554922 @default.
- W2171297737 hasConceptScore W2171297737C134018914 @default.
- W2171297737 hasConceptScore W2171297737C168240541 @default.
- W2171297737 hasConceptScore W2171297737C185592680 @default.
- W2171297737 hasConceptScore W2171297737C199096232 @default.
- W2171297737 hasConceptScore W2171297737C207200792 @default.
- W2171297737 hasConceptScore W2171297737C28859421 @default.
- W2171297737 hasConceptScore W2171297737C39133596 @default.
- W2171297737 hasConceptScore W2171297737C42407357 @default.
- W2171297737 hasConceptScore W2171297737C55493867 @default.
- W2171297737 hasConceptScore W2171297737C7301908 @default.
- W2171297737 hasConceptScore W2171297737C79879829 @default.
- W2171297737 hasConceptScore W2171297737C86803240 @default.
- W2171297737 hasConceptScore W2171297737C95444343 @default.
- W2171297737 hasFunder F4320320893 @default.
- W2171297737 hasFunder F4320321018 @default.
- W2171297737 hasFunder F4320321589 @default.
- W2171297737 hasFunder F4320322892 @default.