FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171308531> ?p ?o ?g. }

• W2171308531 endingPage "552" @default.
• W2171308531 startingPage "539" @default.
• W2171308531 abstract "Rationale: Autologous bone marrow–derived or cardiac-derived stem cell therapy for heart disease has demonstrated safety and efficacy in clinical trials, but functional improvements have been limited. Finding the optimal stem cell type best suited for cardiac regeneration is the key toward improving clinical outcomes. Objective: To determine the mechanism by which novel bone-derived stem cells support the injured heart. Methods and Results: Cortical bone–derived stem cells (CBSCs) and cardiac-derived stem cells were isolated from enhanced green fluorescent protein (EGFP+) transgenic mice and were shown to express c-kit and Sca-1 as well as 8 paracrine factors involved in cardioprotection, angiogenesis, and stem cell function. Wild-type C57BL/6 mice underwent sham operation (n=21) or myocardial infarction with injection of CBSCs (n=67), cardiac-derived stem cells (n=36), or saline (n=60). Cardiac function was monitored using echocardiography. Only 2/8 paracrine factors were detected in EGFP+ CBSCs in vivo (basic fibroblast growth factor and vascular endothelial growth factor), and this expression was associated with increased neovascularization of the infarct border zone. CBSC therapy improved survival, cardiac function, regional strain, attenuated remodeling, and decreased infarct size relative to cardiac-derived stem cells– or saline-treated myocardial infarction controls. By 6 weeks, EGFP+ cardiomyocytes, vascular smooth muscle, and endothelial cells could be identified in CBSC-treated, but not in cardiac-derived stem cells–treated, animals. EGFP+ CBSC-derived isolated myocytes were smaller and more frequently mononucleated, but were functionally indistinguishable from EGFP− myocytes. Conclusions: CBSCs improve survival, cardiac function, and attenuate remodeling through the following 2 mechanisms: (1) secretion of proangiogenic factors that stimulate endogenous neovascularization, and (2) differentiation into functional adult myocytes and vascular cells." @default.
• W2171308531 created "2016-06-24" @default.
• W2171308531 creator A5000191366 @default.
• W2171308531 creator A5011101977 @default.
• W2171308531 creator A5016286747 @default.
• W2171308531 creator A5040103196 @default.
• W2171308531 creator A5047112099 @default.
• W2171308531 creator A5067892109 @default.
• W2171308531 creator A5074296319 @default.
• W2171308531 creator A5075449965 @default.
• W2171308531 creator A5076883639 @default.
• W2171308531 creator A5083806931 @default.
• W2171308531 creator A5085766566 @default.
• W2171308531 date "2013-08-16" @default.
• W2171308531 modified "2023-10-17" @default.
• W2171308531 title "Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms" @default.
• W2171308531 cites W1631250427 @default.
• W2171308531 cites W1963756072 @default.
• W2171308531 cites W1985797014 @default.
• W2171308531 cites W1987506766 @default.
• W2171308531 cites W1999631700 @default.
• W2171308531 cites W2005654557 @default.
• W2171308531 cites W2008031660 @default.
• W2171308531 cites W2026019936 @default.
• W2171308531 cites W2026749151 @default.
• W2171308531 cites W2028036560 @default.
• W2171308531 cites W2038775969 @default.
• W2171308531 cites W2046978263 @default.
• W2171308531 cites W2051341102 @default.
• W2171308531 cites W2054095354 @default.
• W2171308531 cites W2056229778 @default.
• W2171308531 cites W2067335193 @default.
• W2171308531 cites W2067591094 @default.
• W2171308531 cites W2069019884 @default.
• W2171308531 cites W2073420780 @default.
• W2171308531 cites W2079784916 @default.
• W2171308531 cites W2080539468 @default.
• W2171308531 cites W2082714048 @default.
• W2171308531 cites W2084887187 @default.
• W2171308531 cites W2090041902 @default.
• W2171308531 cites W2097834438 @default.
• W2171308531 cites W2100448471 @default.
• W2171308531 cites W2104820453 @default.
• W2171308531 cites W2105840074 @default.
• W2171308531 cites W2111486034 @default.
• W2171308531 cites W2111824172 @default.
• W2171308531 cites W2112777549 @default.
• W2171308531 cites W2114222046 @default.
• W2171308531 cites W2116500923 @default.
• W2171308531 cites W2121408705 @default.
• W2171308531 cites W2124396531 @default.
• W2171308531 cites W2128085444 @default.
• W2171308531 cites W2130794824 @default.
• W2171308531 cites W2132735690 @default.
• W2171308531 cites W2140922568 @default.
• W2171308531 cites W2142602321 @default.
• W2171308531 cites W2144327104 @default.
• W2171308531 cites W2148220540 @default.
• W2171308531 cites W2153899938 @default.
• W2171308531 cites W2155932838 @default.
• W2171308531 cites W2156140279 @default.
• W2171308531 cites W2158682140 @default.
• W2171308531 cites W2159182678 @default.
• W2171308531 cites W2165368329 @default.
• W2171308531 cites W82391255 @default.
• W2171308531 doi "https://doi.org/10.1161/circresaha.113.301202" @default.
• W2171308531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3822430" @default.
• W2171308531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23801066" @default.
• W2171308531 hasPublicationYear "2013" @default.
• W2171308531 type Work @default.
• W2171308531 sameAs 2171308531 @default.
• W2171308531 citedByCount "150" @default.
• W2171308531 countsByYear W21713085312013 @default.
• W2171308531 countsByYear W21713085312014 @default.
• W2171308531 countsByYear W21713085312015 @default.
• W2171308531 countsByYear W21713085312016 @default.
• W2171308531 countsByYear W21713085312017 @default.
• W2171308531 countsByYear W21713085312018 @default.
• W2171308531 countsByYear W21713085312019 @default.
• W2171308531 countsByYear W21713085312020 @default.
• W2171308531 countsByYear W21713085312021 @default.
• W2171308531 countsByYear W21713085312022 @default.
• W2171308531 countsByYear W21713085312023 @default.
• W2171308531 crossrefType "journal-article" @default.
• W2171308531 hasAuthorship W2171308531A5000191366 @default.
• W2171308531 hasAuthorship W2171308531A5011101977 @default.
• W2171308531 hasAuthorship W2171308531A5016286747 @default.
• W2171308531 hasAuthorship W2171308531A5040103196 @default.
• W2171308531 hasAuthorship W2171308531A5047112099 @default.
• W2171308531 hasAuthorship W2171308531A5067892109 @default.
• W2171308531 hasAuthorship W2171308531A5074296319 @default.
• W2171308531 hasAuthorship W2171308531A5075449965 @default.
• W2171308531 hasAuthorship W2171308531A5076883639 @default.
• W2171308531 hasAuthorship W2171308531A5083806931 @default.
• W2171308531 hasAuthorship W2171308531A5085766566 @default.
• W2171308531 hasBestOaLocation W21713085311 @default.
• W2171308531 hasConcept C111566952 @default.
• W2171308531 hasConcept C126322002 @default.

• next