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- W2171314882 abstract "Microcalorimeters to monitor the heat dissipation of bench-scale animal cell cultures on line and in real time require a continuous circuit between the vessel measuring heat flow rate and the bioreactor. The modifications to the transmission lines and calorimetric heat exchanger were to: (i) reverse the usual upward direction of the cell suspension in the flow vessel to downwards; (ii) install an in situ washing/cleaning facility; (iii) use low diffusivity PEEK material; and (iv) maintain thermal equilibration by water-jacketing the transmission tubing. Chemical calibration showed that there was more than a 20% difference between the physical volume and the effective thermal volume. An appropriate thermodynamic system was defined in order to permit enthalpy balance studies." @default.
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- W2171314882 date "1997-08-01" @default.
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- W2171314882 title "A modified continuous flow microcalorimeter for measuring heat dissipation by mammalian cells in batch culture" @default.
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- W2171314882 doi "https://doi.org/10.1007/bf01996761" @default.
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