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• W2171336975 abstract "B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias of the elderly. To date, although many prognostic factors are known, none are universal or easily accessible thus allowing for the stratification of patients to slow-go and aggressive-course groups. Recent studies have identified new recurrent mutations in CLL cells, including mutation of the gene encoding one of the spliceosome subunits, SF3B1, mutation or rearrangement of NOTCH1, a gene of well-known tumorigenesis association, and disruption of BIRC3, a member of the inhibitors of apoptosis (IAP) family. This article presents the current state-of-the-art findings concerning the prognostic significance of these new alterations, as well as an explanation of the mechanisms underlying their biological impact on CLL lymphocytes." @default.
• W2171336975 created "2016-06-24" @default.
• W2171336975 creator A5068678082 @default.
• W2171336975 date "2013-02-20" @default.
• W2171336975 modified "2023-09-23" @default.
• W2171336975 title "New boys in town: prognostic role ofSF3B1, NOTCH1and other cryptic alterations in chronic lymphocytic leukemia and how it works" @default.
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• W2171336975 doi "https://doi.org/10.3109/10428194.2013.769049" @default.
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